Sinha, Subhash

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selected publications

cGAS inhibition delays TDP-43-driven ALS Pathogenesis. 2026 GET IT
cGAS-mediated IFN-I signaling contributes to disease progression in drug-refractory epilepsy. 2026 GET IT
High-Throughput Screening and Initial SAR Studies Identify a Novel Submicromolar Potent Human cGAS Inhibitor. ACS chemical biology. 2025 Academic Article GET IT
High-Throughput Screening and Initial SAR Studies Identify a Novel Sub-micromolar Potent Human cGAS Inhibitor. 2025 GET IT
The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway. Immunity. 2025 Academic Article GET IT
Times cited: 7
Boolean Network Modeling Identifies Cognitive Resilience in the First Murine Model of Asymptomatic Alzheimer's Disease. 2025 GET IT
Emerging approaches to bridging discovery science with clinical care in Alzheimer's disease. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2025 Editorial Article GET IT
Identification and development of cGAS inhibitors and their uses to treat Alzheimer's disease. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2025 Review GET IT
APOE3-R136S mutation confers resilience against tau pathology via cGAS-STING-IFN inhibition. 2025 GET IT
Editorial: Spotlight on North America - chemical sciences. Frontiers in chemistry. 2024 Editorial Article GET IT
Tlr7 drives sex differences in age- and Alzheimer's disease-related demyelination. Science (New York, N.Y.). 2024 Academic Article GET IT
Stretching the structural envelope of imatinib to reduce β-amyloid production by modulating both β- and γ-secretase cleavages of APP. Frontiers in chemistry. 2024 Academic Article GET IT
Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model. Neuron. 2024 Academic Article GET IT
Anti-acetylated-tau immunotherapy is neuroprotective in tauopathy and brain injury. Molecular neurodegeneration. 2024 Academic Article GET IT
Ahnak in the prefrontal cortex mediates behavioral correlates of stress resilience and rapid antidepressant action in mice. Frontiers in molecular neuroscience. 2024 Academic Article GET IT
A cell autonomous regulator of neuronal excitability modulates tau in Alzheimer's disease vulnerable neurons. Brain : a journal of neurology. 2024 Academic Article GET IT
Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model. 2024 GET IT
Rational Development of a Small-Molecule Activator of CK1γ2 That Decreases C99 and Beta-Amyloid Levels. ACS chemical biology. 2023 Academic Article GET IT
Mechanism and therapeutic potential of targeting cGAS-STING signaling in neurological disorders. Molecular neurodegeneration. 2023 Review GET IT
Tau activation of microglial cGAS-IFN reduces MEF2C-mediated cognitive resilience. Nature neuroscience. 2023 Academic Article GET IT
Times cited: 181
TrkA expression directs the anti-neoplastic activity of MLK3 inhibitors in triple-negative breast cancer. Oncogene. 2023 Academic Article GET IT
AD-linked R47H-TREM2 mutation induces disease-enhancing microglial states via AKT hyperactivation. Science translational medicine. 2021 Academic Article GET IT
Times cited: 95
MAP4K4 promotes pancreatic tumorigenesis via phosphorylation and activation of mixed lineage kinase 3. Oncogene. 2021 Academic Article GET IT
Mixed Lineage Kinase 3 phosphorylates prolyl-isomerase PIN1 and potentiates GLI1 signaling in pancreatic cancer development. Cancer letters. 2021 Academic Article GET IT
A Pentacyclic Triterpene from Ligustrum lucidum Targets γ-Secretase. ACS chemical neuroscience. 2020 Academic Article GET IT
Rationalized inhibition of mixed lineage kinase 3 and CD70 enhances life span and antitumor efficacy of CD8⁺ T cells. Journal for immunotherapy of cancer. 2020 Academic Article GET IT
Times cited: 14
Mixed lineage kinase 3 inhibition induces T cell activation and cytotoxicity. Proceedings of the National Academy of Sciences of the United States of America. 2020 Academic Article GET IT
Times cited: 21
Brain Permeable Tafamidis Amide Analogs for Stabilizing TTR and Reducing APP Cleavage. ACS medicinal chemistry letters. 2020 Academic Article GET IT
Times cited: 13
Reduced Kv3.1 Activity in Dentate Gyrus Parvalbumin Cells Induces Vulnerability to Depression. Biological psychiatry. 2020 Academic Article GET IT
Times cited: 8
Development of Kinase Inactive PD173955 Analogues for Reducing Production of Aβ Peptides. ACS medicinal chemistry letters. 2019 Academic Article GET IT
Development of Gleevec Analogues for Reducing Production of β-Amyloid Peptides through Shifting β-Cleavage of Amyloid Precursor Proteins. Journal of medicinal chemistry. 2019 Academic Article GET IT
Times cited: 3
Bidirectional regulation of Aβ levels by Presenilin 1. Proceedings of the National Academy of Sciences of the United States of America. 2017 Academic Article GET IT
Times cited: 38
Transcriptional regulation of mixed lineage kinase 3 by estrogen and its implication in ER-positive breast cancer pathogenesis. Oncotarget. 2017 Academic Article GET IT
Times cited: 6
SMI-Ribosome inactivating protein conjugates selectively inhibit tumor cell growth. Chemical communications (Cambridge, England). 2017 Academic Article GET IT
Times cited: 7
Gleevec shifts APP processing from a β-cleavage to a nonamyloidogenic cleavage. Proceedings of the National Academy of Sciences of the United States of America. 2017 Academic Article GET IT
Times cited: 23
Activation of respiratory Complex I from Escherichia coli studied by fluorescent probes. Heliyon. 2017 Academic Article GET IT
Chemically Programmed Bispecific Antibodies in Diabody Format. The Journal of biological chemistry. 2016 Academic Article GET IT
Times cited: 33
Chemically Programmed Bispecific Antibody Targeting Legumain Protease and αvβ3 Integrin Mediates Strong Antitumor Effects. Molecular pharmaceutics. 2015 Academic Article GET IT
Times cited: 16
Conserved amino acid residues of the NuoD segment important for structure and function of Escherichia coli NDH-1 (complex I). Biochemistry. 2015 Academic Article GET IT
Times cited: 27
Undesired versus designed enzymatic cleavage of linkers for liver targeting. Bioorganic & medicinal chemistry letters. 2014 Academic Article GET IT
Genetic incorporation of multiple unnatural amino acids into proteins in mammalian cells. Angewandte Chemie (International ed. in English). 2013 Academic Article GET IT
Times cited: 116
Semiquinone and cluster N6 signals in His-tagged proton-translocating NADH:ubiquinone oxidoreductase (complex I) from Escherichia coli. The Journal of biological chemistry. 2013 Academic Article GET IT
Times cited: 12
Synthesis and evaluation of the aldolase antibody-derived chemical-antibodies targeting α5β1 integrin. Molecular pharmaceutics. 2012 Academic Article GET IT
Times cited: 8
Synthesis of site-specific antibody-drug conjugates using unnatural amino acids. Proceedings of the National Academy of Sciences of the United States of America. 2012 Academic Article GET IT
Times cited: 536
Targeting cell surface alpha(v)beta(3) integrin increases therapeutic efficacies of a legumain protease-activated auristatin prodrug. Molecular pharmaceutics. 2011 Academic Article GET IT
Times cited: 80
Tissue factor-activated coagulation cascade in the tumor microenvironment is critical for tumor progression and an effective target for therapy. Cancer research. 2011 Academic Article GET IT
Times cited: 69
Chemically programmed antibodies targeting multiple alpha(v) integrins and their effects on tumor-related functions in vitro. Bioconjugate chemistry. 2011 Academic Article GET IT
Times cited: 8
The legumain protease-activated auristatin prodrugs suppress tumor growth and metastasis without toxicity. ChemMedChem. 2011 Academic Article GET IT
Times cited: 61
Studies toward a library of tetrahydrofurans: click and MCR products of mono- and bis-tetrahydrofurans. Journal of combinatorial chemistry. 2010 Academic Article GET IT
Times cited: 8
The membrane subunit NuoL(ND5) is involved in the indirect proton pumping mechanism of Escherichia coli complex I. The Journal of biological chemistry. 2010 Academic Article GET IT
Times cited: 87
The ND2 subunit is labeled by a photoaffinity analogue of asimicin, a potent complex I inhibitor. FEBS letters. 2010 Academic Article GET IT
Times cited: 58
Studies toward the duocarmycin prodrugs for the antibody prodrug therapy approach. Tetrahedron letters. 2009 Academic Article GET IT
An efficient chemical approach to bispecific antibodies and antibodies of high valency. Bioorganic & medicinal chemistry letters. 2009 Academic Article GET IT
Times cited: 40
Multiple catalytic aldolase antibodies suitable for chemical programming. Bioorganic & medicinal chemistry letters. 2009 Academic Article GET IT
Times cited: 13
Instant immunity through chemically programmable vaccination and covalent self-assembly. Proceedings of the National Academy of Sciences of the United States of America. 2009 Academic Article GET IT
Times cited: 41
Alteration of the bis-tetrahydrofuran core stereochemistries in asimicin can affect the cytotoxicity. Journal of medicinal chemistry. 2008 Academic Article GET IT
Times cited: 22
Studies toward the total synthesis of sorangiolides and their analogues. A convergent stereoselective synthesis of the macrocyclic lactone precursors. Organic letters. 2007 Academic Article GET IT
Times cited: 10
Synthesis of the next-generation therapeutic antibodies that combine cell targeting and antibody-catalyzed prodrug activation. Proceedings of the National Academy of Sciences of the United States of America. 2007 Academic Article GET IT
Times cited: 37
Rhenium(VII) oxide catalyzed heteroacylative ring-opening dimerization of tetrahydrofuran. Journal of the American Chemical Society. 2007 Academic Article GET IT
Times cited: 30
Preparation of integrin alpha(v)beta3-targeting Ab 38C2 constructs. Nature protocols. 2007 Academic Article GET IT
Times cited: 21
Small molecule drug activity in melanoma models may be dramatically enhanced with an antibody effector. International journal of cancer. 2006 Academic Article GET IT
Times cited: 36
Breaking the one antibody-one target axiom. Proceedings of the National Academy of Sciences of the United States of America. 2006 Academic Article GET IT
Times cited: 29
Synthesis and evaluation of photolabile insulin prodrugs. Bioorganic & medicinal chemistry letters. 2005 Academic Article GET IT
Times cited: 3
A bidirectional approach to the synthesis of a complete library of adjacent-bis-THF annonaceous acetogenins. The Journal of organic chemistry. 2005 Academic Article GET IT
Times cited: 32
Origin of selectivity in the antibody 20F10-catalyzed Yang cyclization. Journal of the American Chemical Society. 2005 Academic Article GET IT
Times cited: 9
Chemical adaptor immunotherapy: design, synthesis, and evaluation of novel integrin-targeting devices. Journal of medicinal chemistry. 2004 Academic Article GET IT
Times cited: 36
Aldolase antibody activation of prodrugs of potent aldehyde-containing cytotoxics for selective chemotherapy. Chemistry (Weinheim an der Bergstrasse, Germany). 2004 Academic Article GET IT
Times cited: 8
Total synthesis of 34-hydroxyasimicin and its photoactive derivative for affinity labeling of the mitochondrial complex I. Chemistry (Weinheim an der Bergstrasse, Germany). 2004 Academic Article GET IT
Times cited: 26
Prodrugs of dynemicin analogs for selective chemotherapy mediated by an aldolase catalytic Ab. Proceedings of the National Academy of Sciences of the United States of America. 2004 Academic Article GET IT
Times cited: 30
Efficient one-step aldol-type reaction of ketones with acetals and ketals mediated by dibutylboron triflate/diisopropylethyl amine. Organic letters. 2004 Academic Article GET IT
Stereoselective aldol-type cyclization reaction mediated by dibutylboron triflate/diisopropylethylamine. Organic letters. 2004 Academic Article GET IT
A humanized aldolase antibody for selective chemotherapy and adaptor immunotherapy. Journal of molecular biology. 2003 Academic Article GET IT
Times cited: 64
Chemically programmed monoclonal antibodies for cancer therapy: adaptor immunotherapy based on a covalent antibody catalyst. Proceedings of the National Academy of Sciences of the United States of America. 2003 Academic Article GET IT
Times cited: 87
Antibody-catalyzed enantioselective Norrish type II cyclization. Angewandte Chemie (International ed. in English). 2003 Academic Article GET IT
Times cited: 11
Stereoselective total synthesis of epothilones by the metathesis approach involving C9-C10 bond formation. Angewandte Chemie (International ed. in English). 2002 Academic Article GET IT
Times cited: 47
Synthesis of epothilone analogues by antibody-catalyzed resolution of thiazole aldol synthons on a multigram scale. Biological consequences of C-13 alkylation of epothilones. Chembiochem : a European journal of chemical biology. 2001 Academic Article GET IT
Times cited: 14
Catalytic antibody route to the naturally occurring epothilones: total synthesis of epothilones A-F. Chemistry (Weinheim an der Bergstrasse, Germany). 2001 Academic Article GET IT
Times cited: 43
Total synthesis of asimicin and bullatacin. The Journal of organic chemistry. 2000 Academic Article GET IT
Times cited: 84
Sets of aldolase antibodies with antipodal reactivities. Formal synthesis of epothilone E by large-scale antibody-catalyzed resolution of thiazole aldol. Organic letters. 1999 Academic Article GET IT
Times cited: 48
The antibody catalysis route to the total synthesis of epothilones. Proceedings of the National Academy of Sciences of the United States of America. 1998 Academic Article GET IT
Times cited: 98
Catalytic Enantioselective Retro-Aldol Reactions: Kinetic Resolution of β-Hydroxyketones with Aldolase Antibodies. Angewandte Chemie (International ed. in English). 1998 Academic Article GET IT
Total Synthesis of Uvaricin. The Journal of organic chemistry. 1998 Academic Article GET IT
Total Synthesis of (+)-Aspicilin. The Naked Carbon Skeleton Strategy vs the Bioorganic Approach. The Journal of organic chemistry. 1997 Academic Article GET IT
Toward Chemical Libraries of Annonaceous Acetogenins. Total Synthesis of Trilobacin. The Journal of organic chemistry. 1996 Academic Article GET IT
Using antibodies to perturb the coordination sphere of a transition metal complex. Nature. 1996 Academic Article GET IT
Times cited: 26
Antibody-catalyzed reversal of chemoselectivity. Proceedings of the National Academy of Sciences of the United States of America. 1993 Academic Article GET IT
Times cited: 29

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Research

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Co-investigator Network

Funding awarded

Identification and development of CD33 inhibitors and pre-RNA splicing modulators awarded by Cure Alzheimer’s Fund Principal Investigator 2023 - 2026
cGAS inhibitors for Alzheimer''s disease treatment awarded by National Institute on Aging Principal Investigator 2021 - 2026

Sex-biased TLR7 signaling in demyelination and its inhibition by small molecules awarded by Cure Alzheimer’s Fund Co-Investigator 2025 - 2026
Acetylated Tau Immunotherapy for Alzheimer''s Disease awarded by National Institute on Aging Co-Investigator 2025 - 2026
Methods to optimize the human cGAS inhibitor leads Co-Investigator 2025 - 2026
Evaluation of a novel human cGAS inhibitor using human iPSC derived models awarded by Harrington Discovery Institute, The Co-Investigator 2024 - 2026
missing activity Co-Investigator 2024 - 2025
missing activity Co-Investigator 2023 - 2024
missing activity Co-Investigator 2021 - 2024
missing activity Co-Investigator 2021 - 2024

cGAS inhibitors for Alzheimer''s disease treatment awarded by National Institute on Aging Co-Principal Investigator 2021 - 2026

missing activity Key Personnel 2023 - 2025

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Background

education and training

M.Sc., Patna University (India) 83
Ph.D., Banaras Hindu University (India) 1988
B.Sc., Patna University (India) 1980

Contact

full name

Subhash Sinha

primary email

sus2044@med.cornell.edu

VIVO Weill Cornell Medical College

Subhash Sinha Professor of Research in Neuroscience

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email