selected publications
- Stretching the structural envelope of imatinib to reduce β-amyloid production by modulating both β- and γ-secretase cleavages of APP. Frontiers in chemistry. 2024 Academic Article GET IT
- Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model. Neuron. 2024 Academic Article GET IT
- Anti-acetylated-tau immunotherapy is neuroprotective in tauopathy and brain injury. Molecular neurodegeneration. 2024 Academic Article GET IT
- Ahnak in the prefrontal cortex mediates behavioral correlates of stress resilience and rapid antidepressant action in mice. Frontiers in molecular neuroscience. 2024 Academic Article GET IT
- APOE3 - R136S mutation confers resilience against tau pathology via cGAS-STING-IFN inhibition. 2024 GET IT
- A cell autonomous regulator of neuronal excitability modulates tau in Alzheimer's disease vulnerable neurons. Brain : a journal of neurology. 2024 Academic Article GET IT
- Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model. 2024 GET IT
- Rational Development of a Small-Molecule Activator of CK1γ2 That Decreases C99 and Beta-Amyloid Levels. ACS chemical biology. 2023 Academic Article GET IT
- Mechanism and therapeutic potential of targeting cGAS-STING signaling in neurological disorders. Molecular neurodegeneration. 2023 Review GET IT
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Tau activation of microglial cGAS-IFN reduces MEF2C-mediated cognitive resilience.
Nature neuroscience.
2023
Academic Article
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Times cited: 32 - TrkA expression directs the anti-neoplastic activity of MLK3 inhibitors in triple-negative breast cancer. Oncogene. 2023 Academic Article GET IT
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AD-linked R47H-TREM2 mutation induces disease-enhancing microglial states via AKT hyperactivation.
Science translational medicine.
2021
Academic Article
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Times cited: 55 - MAP4K4 promotes pancreatic tumorigenesis via phosphorylation and activation of mixed lineage kinase 3. Oncogene. 2021 Academic Article GET IT
- Mixed Lineage Kinase 3 phosphorylates prolyl-isomerase PIN1 and potentiates GLI1 signaling in pancreatic cancer development. Cancer letters. 2021 Academic Article GET IT
- A Pentacyclic Triterpene from Ligustrum lucidum Targets γ-Secretase. ACS chemical neuroscience. 2020 Academic Article GET IT
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Rationalized inhibition of mixed lineage kinase 3 and CD70 enhances life span and antitumor efficacy of CD8+ T cells.
Journal for immunotherapy of cancer.
2020
Academic Article
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Times cited: 12 -
Mixed lineage kinase 3 inhibition induces T cell activation and cytotoxicity.
Proceedings of the National Academy of Sciences of the United States of America.
2020
Academic Article
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Times cited: 17 -
Brain Permeable Tafamidis Amide Analogs for Stabilizing TTR and Reducing APP Cleavage.
ACS medicinal chemistry letters.
2020
Academic Article
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Times cited: 10 -
Reduced Kv3.1 Activity in Dentate Gyrus Parvalbumin Cells Induces Vulnerability to Depression.
Biological psychiatry.
2020
Academic Article
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Times cited: 8 - Development of Kinase Inactive PD173955 Analogues for Reducing Production of Aβ Peptides. ACS medicinal chemistry letters. 2019 Academic Article GET IT
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Development of Gleevec Analogues for Reducing Production of β-Amyloid Peptides through Shifting β-Cleavage of Amyloid Precursor Proteins.
Journal of medicinal chemistry.
2019
Academic Article
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Times cited: 3 -
Bidirectional regulation of Aβ levels by Presenilin 1.
Proceedings of the National Academy of Sciences of the United States of America.
2017
Academic Article
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Times cited: 36 -
Transcriptional regulation of mixed lineage kinase 3 by estrogen and its implication in ER-positive breast cancer pathogenesis.
Oncotarget.
2017
Academic Article
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Times cited: 5 -
SMI-Ribosome inactivating protein conjugates selectively inhibit tumor cell growth.
Chemical communications (Cambridge, England).
2017
Academic Article
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Times cited: 7 -
Gleevec shifts APP processing from a β-cleavage to a nonamyloidogenic cleavage.
Proceedings of the National Academy of Sciences of the United States of America.
2017
Academic Article
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Times cited: 22 - Activation of respiratory Complex I from Escherichia coli studied by fluorescent probes. Heliyon. 2017 Academic Article GET IT
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Chemically Programmed Bispecific Antibodies in Diabody Format.
The Journal of biological chemistry.
2016
Academic Article
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Times cited: 33 -
Chemically Programmed Bispecific Antibody Targeting Legumain Protease and αvβ3 Integrin Mediates Strong Antitumor Effects.
Molecular pharmaceutics.
2015
Academic Article
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Times cited: 15 -
Conserved amino acid residues of the NuoD segment important for structure and function of Escherichia coli NDH-1 (complex I).
Biochemistry.
2015
Academic Article
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Times cited: 26 - Undesired versus designed enzymatic cleavage of linkers for liver targeting. Bioorganic & medicinal chemistry letters. 2014 Academic Article GET IT
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Genetic incorporation of multiple unnatural amino acids into proteins in mammalian cells.
Angewandte Chemie (International ed. in English).
2013
Academic Article
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Times cited: 116 -
Semiquinone and cluster N6 signals in His-tagged proton-translocating NADH:ubiquinone oxidoreductase (complex I) from Escherichia coli.
The Journal of biological chemistry.
2013
Academic Article
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Times cited: 11 -
Synthesis and evaluation of the aldolase antibody-derived chemical-antibodies targeting α5β1 integrin.
Molecular pharmaceutics.
2012
Academic Article
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Times cited: 8 -
Synthesis of site-specific antibody-drug conjugates using unnatural amino acids.
Proceedings of the National Academy of Sciences of the United States of America.
2012
Academic Article
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Times cited: 491 -
Targeting cell surface alpha(v)beta(3) integrin increases therapeutic efficacies of a legumain protease-activated auristatin prodrug.
Molecular pharmaceutics.
2011
Academic Article
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Times cited: 74 -
Tissue factor-activated coagulation cascade in the tumor microenvironment is critical for tumor progression and an effective target for therapy.
Cancer research.
2011
Academic Article
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Times cited: 69 -
Chemically programmed antibodies targeting multiple alpha(v) integrins and their effects on tumor-related functions in vitro.
Bioconjugate chemistry.
2011
Academic Article
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Times cited: 8 -
The legumain protease-activated auristatin prodrugs suppress tumor growth and metastasis without toxicity.
ChemMedChem.
2011
Academic Article
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Times cited: 54 -
Studies toward a library of tetrahydrofurans: click and MCR products of mono- and bis-tetrahydrofurans.
Journal of combinatorial chemistry.
2010
Academic Article
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Times cited: 8 -
The membrane subunit NuoL(ND5) is involved in the indirect proton pumping mechanism of Escherichia coli complex I.
The Journal of biological chemistry.
2010
Academic Article
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Times cited: 83 -
The ND2 subunit is labeled by a photoaffinity analogue of asimicin, a potent complex I inhibitor.
FEBS letters.
2010
Academic Article
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Times cited: 54 - Studies toward the duocarmycin prodrugs for the antibody prodrug therapy approach. Tetrahedron letters. 2009 Academic Article GET IT
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An efficient chemical approach to bispecific antibodies and antibodies of high valency.
Bioorganic & medicinal chemistry letters.
2009
Academic Article
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Times cited: 39 -
Multiple catalytic aldolase antibodies suitable for chemical programming.
Bioorganic & medicinal chemistry letters.
2009
Academic Article
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Times cited: 12 -
Instant immunity through chemically programmable vaccination and covalent self-assembly.
Proceedings of the National Academy of Sciences of the United States of America.
2009
Academic Article
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Times cited: 40 -
Alteration of the bis-tetrahydrofuran core stereochemistries in asimicin can affect the cytotoxicity.
Journal of medicinal chemistry.
2008
Academic Article
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Times cited: 22 -
Studies toward the total synthesis of sorangiolides and their analogues. A convergent stereoselective synthesis of the macrocyclic lactone precursors.
Organic letters.
2007
Academic Article
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Times cited: 10 -
Synthesis of the next-generation therapeutic antibodies that combine cell targeting and antibody-catalyzed prodrug activation.
Proceedings of the National Academy of Sciences of the United States of America.
2007
Academic Article
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Times cited: 37 -
Rhenium(VII) oxide catalyzed heteroacylative ring-opening dimerization of tetrahydrofuran.
Journal of the American Chemical Society.
2007
Academic Article
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Times cited: 30 -
Preparation of integrin alpha(v)beta3-targeting Ab 38C2 constructs.
Nature protocols.
2007
Academic Article
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Times cited: 21 -
Small molecule drug activity in melanoma models may be dramatically enhanced with an antibody effector.
International journal of cancer.
2006
Academic Article
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Times cited: 36 -
Breaking the one antibody-one target axiom.
Proceedings of the National Academy of Sciences of the United States of America.
2006
Academic Article
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Times cited: 29 -
Synthesis and evaluation of photolabile insulin prodrugs.
Bioorganic & medicinal chemistry letters.
2005
Academic Article
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Times cited: 3 -
A bidirectional approach to the synthesis of a complete library of adjacent-bis-THF annonaceous acetogenins.
The Journal of organic chemistry.
2005
Academic Article
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Times cited: 32 -
Origin of selectivity in the antibody 20F10-catalyzed Yang cyclization.
Journal of the American Chemical Society.
2005
Academic Article
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Times cited: 9 -
Chemical adaptor immunotherapy: design, synthesis, and evaluation of novel integrin-targeting devices.
Journal of medicinal chemistry.
2004
Academic Article
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Times cited: 36 -
Aldolase antibody activation of prodrugs of potent aldehyde-containing cytotoxics for selective chemotherapy.
Chemistry (Weinheim an der Bergstrasse, Germany).
2004
Academic Article
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Times cited: 8 -
Total synthesis of 34-hydroxyasimicin and its photoactive derivative for affinity labeling of the mitochondrial complex I.
Chemistry (Weinheim an der Bergstrasse, Germany).
2004
Academic Article
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Times cited: 26 -
Prodrugs of dynemicin analogs for selective chemotherapy mediated by an aldolase catalytic Ab.
Proceedings of the National Academy of Sciences of the United States of America.
2004
Academic Article
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Times cited: 30 - Efficient one-step aldol-type reaction of ketones with acetals and ketals mediated by dibutylboron triflate/diisopropylethyl amine. Organic letters. 2004 Academic Article GET IT
- Stereoselective aldol-type cyclization reaction mediated by dibutylboron triflate/diisopropylethylamine. Organic letters. 2004 Academic Article GET IT
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A humanized aldolase antibody for selective chemotherapy and adaptor immunotherapy.
Journal of molecular biology.
2003
Academic Article
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Times cited: 64 -
Chemically programmed monoclonal antibodies for cancer therapy: adaptor immunotherapy based on a covalent antibody catalyst.
Proceedings of the National Academy of Sciences of the United States of America.
2003
Academic Article
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Times cited: 87 -
Antibody-catalyzed enantioselective Norrish type II cyclization.
Angewandte Chemie (International ed. in English).
2003
Academic Article
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Times cited: 11 -
Stereoselective total synthesis of epothilones by the metathesis approach involving C9-C10 bond formation.
Angewandte Chemie (International ed. in English).
2002
Academic Article
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Times cited: 47 -
Synthesis of epothilone analogues by antibody-catalyzed resolution of thiazole aldol synthons on a multigram scale. Biological consequences of C-13 alkylation of epothilones.
Chembiochem : a European journal of chemical biology.
2001
Academic Article
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Times cited: 14 -
Catalytic antibody route to the naturally occurring epothilones: total synthesis of epothilones A-F.
Chemistry (Weinheim an der Bergstrasse, Germany).
2001
Academic Article
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Times cited: 43 -
Total synthesis of asimicin and bullatacin.
The Journal of organic chemistry.
2000
Academic Article
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Times cited: 84 -
Sets of aldolase antibodies with antipodal reactivities. Formal synthesis of epothilone E by large-scale antibody-catalyzed resolution of thiazole aldol.
Organic letters.
1999
Academic Article
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Times cited: 48 -
The antibody catalysis route to the total synthesis of epothilones.
Proceedings of the National Academy of Sciences of the United States of America.
1998
Academic Article
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Times cited: 94 - Catalytic Enantioselective Retro-Aldol Reactions: Kinetic Resolution of β-Hydroxyketones with Aldolase Antibodies. Angewandte Chemie (International ed. in English). 1998 Academic Article GET IT
- Total Synthesis of Uvaricin. The Journal of organic chemistry. 1998 Academic Article GET IT
- Total Synthesis of (+)-Aspicilin. The Naked Carbon Skeleton Strategy vs the Bioorganic Approach. The Journal of organic chemistry. 1997 Academic Article GET IT
- Toward Chemical Libraries of Annonaceous Acetogenins. Total Synthesis of Trilobacin. The Journal of organic chemistry. 1996 Academic Article GET IT
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Using antibodies to perturb the coordination sphere of a transition metal complex.
Nature.
1996
Academic Article
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Times cited: 26 -
Antibody-catalyzed reversal of chemoselectivity.
Proceedings of the National Academy of Sciences of the United States of America.
1993
Academic Article
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Times cited: 29