Role of Nod2 in the development of Crohn's disease. Review uri icon

Overview

abstract

  • Crohn's Disease (CD) is caused by a loss of the regulatory capacity of the immune apparatus. Nod2 is an intracellular bacterial sensor and its mutations are associated with the development of CD. Here we summarize recent and controversial findings about the role of the Nod2 mutants in the disease process.

publication date

  • June 30, 2009

Research

keywords

  • Crohn Disease
  • Inflammation
  • Mutant Proteins
  • Nod2 Signaling Adaptor Protein

Identity

PubMed Central ID

  • PMC2924159

Scopus Document Identifier

  • 69249248197

Digital Object Identifier (DOI)

  • 10.1016/j.micinf.2009.06.005

PubMed ID

  • 19573617

Additional Document Info

volume

  • 11

issue

  • 12