A focal lesion in the falx cerebri: Harbinger of classic stage 4 neuroblastoma in an infant cured despite residual disease after minimal therapy. uri icon

Overview

abstract

  • An asymptomatic 11-week-old male received no treatment after he was classified as having a suspected atypical form of MYCN-nonamplified hyperdiploid stage 4S neuroblastoma (NB), with masses in an adrenal gland, subcutaneous tissues, and the falx cerebri. Within 2 months, however, disease progressed in dura and bone marrow. Two cycles of low-dose chemotherapy achieved a partial response; treatment was discontinued. Complete remission was documented 24 weeks post-cycle 2, and has continued >6 years. The falx cerebri probably does not represent an atypical site for stage 4S NB, but stage 4 NB with favorable biology is sometimes curable with minimal therapy.

publication date

  • December 15, 2009

Research

keywords

  • Adrenal Gland Neoplasms
  • Antineoplastic Combined Chemotherapy Protocols
  • Dura Mater
  • Meningeal Neoplasms
  • Neuroblastoma

Identity

PubMed Central ID

  • PMC2394373

Scopus Document Identifier

  • 70449729868

Digital Object Identifier (DOI)

  • 10.1002/pbc.22243

PubMed ID

  • 19711437

Additional Document Info

volume

  • 53

issue

  • 7