Caspase 9 is essential for herpes simplex virus type 2-induced apoptosis in T cells. Academic Article uri icon

Overview

abstract

  • Herpes simplex virus type 2 (HSV-2) induces apoptosis in T cells by a caspase-dependent mechanism. Apoptosis can occur via extrinsic (death receptor) and/or intrinsic (mitochondrial) pathways. Here, we show that the initiator caspase for the intrinsic pathway is activated in T cells following HSV-2 exposure. To determine the respective contributions of intrinsic and extrinsic pathways, we assessed apoptosis in Jurkat cells that are deficient in caspase 8 or Fas-associating protein with death domain (FADD) for the extrinsic pathway and in cells deficient in caspase 9 for the intrinsic pathway. Our results indicate HSV-2-induced apoptosis in T cells occurs via the intrinsic pathway.

publication date

  • January 13, 2010

Research

keywords

  • Apoptosis
  • Caspase 9
  • Herpesvirus 2, Human
  • T-Lymphocytes

Identity

PubMed Central ID

  • PMC2826057

Scopus Document Identifier

  • 77649112705

Digital Object Identifier (DOI)

  • 10.1128/JVI.01726-09

PubMed ID

  • 20071584

Additional Document Info

volume

  • 84

issue

  • 6