Phase II trial of cisplatin and etoposide in patients with metastatic melanoma. Academic Article uri icon

Overview

abstract

  • Fourteen patients with metastatic melanoma were treated with cisplatin and etoposide by bolus intravenous infusion daily for 5 consecutive days each month. All patients were evaluable for toxicity and twelve for response. Eight patients were treated with cisplatin 20 mg/m2 and etoposide 100 mg/m2 daily. Because of excessive myelosuppression, the daily dose of etoposide was reduced to 75 mg/m2 in the remaining six patients. There were no major responses among 12 evaluable patients (major response rate less than or equal to 24% with 95% confidence). The median time to progression was one month. One patient with a liver metastasis had a minor response lasting 6+ months. The combination of cisplatin and etoposide in these doses and schedule lacked sufficient clinical efficacy in the treatment of metastatic melanoma.

publication date

  • February 1, 1991

Research

keywords

  • Antineoplastic Combined Chemotherapy Protocols
  • Melanoma

Identity

Scopus Document Identifier

  • 0026013310

PubMed ID

  • 2026478

Additional Document Info

volume

  • 9

issue

  • 1