Investigational new drugs
Journal
Overview
publication venue for
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Dermatologic side effects associated with the MEK 1/2 inhibitor selumetinib (AZD6244, ARRY-142886).
2010
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Clinical cardiotoxicity of esorubicin (4'-deoxydoxorubicin,DxDx): prospective studies with serial gated heart scans and reports of selected cases. A Cancer and Leukemia Group B report.
1990
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A phase Ib dose escalation study of oral monotherapy with KX2-391 in elderly patients with acute myeloid leukemia..
40.
2022
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A multicenter phase 1/2 study investigating the safety, pharmacokinetics, pharmacodynamics and efficacy of a small molecule antimetabolite, RX-3117, plus nab-paclitaxel in pancreatic adenocarcinoma..
40.
2021
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A decision process for drug discovery in retinoblastoma..
39.
2020
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NCI 6896: a phase I trial of vorinostat (SAHA) and isotretinoin (13-cis retinoic acid) in the treatment of patients with advanced renal cell carcinoma..
38.
2020
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A randomized phase 2 trial of the efficacy and safety of a novel topical povidone-iodine formulation for Cancer therapy-associated Paronychia..
37.
2019
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Clinical pharmacokinetics and pharmacodynamics of ivosidenib, an oral, targeted inhibitor of mutant IDH1, in patients with advanced solid tumors..
38.
2019
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Phase Ib study of the MEK inhibitor cobimetinib (GDC-0973) in combination with the PI3K inhibitor pictilisib (GDC-0941) in patients with advanced solid tumors..
38.
2019
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A phase Ib study of BGJ398, a pan-FGFR kinase inhibitor in combination with imatinib in patients with advanced gastrointestinal stromal tumor..
37.
2018
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A phase I, open-label, two-stage study to investigate the safety, tolerability, pharmacokinetics, and pharmacodynamics of the oral AKT inhibitor GSK2141795 in patients with solid tumors..
36.
2018
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A phase II study of the dual mTOR inhibitor MLN0128 in patients with metastatic castration resistant prostate cancer..
36.
2018
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Ruxolitinib + capecitabine in advanced/metastatic pancreatic cancer after disease progression/intolerance to first-line therapy: JANUS 1 and 2 randomized phase III studies..
36.
2018
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A phase 2 study of ontuxizumab, a monoclonal antibody targeting endosialin, in metastatic melanoma..
36.
2017
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A phase 1b dose expansion study of the pan-class I PI3K inhibitor buparlisib (BKM120) plus carboplatin and paclitaxel in PTEN deficient tumors and with dose intensified carboplatin and paclitaxel..
35.
2017
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Phase 1 study of narnatumab, an anti-RON receptor monoclonal antibody, in patients with advanced solid tumors..
35.
2017
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A phase I dose-escalation study of TAK-733, an investigational oral MEK inhibitor, in patients with advanced solid tumors..
35.
2016
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A phase I study of the investigational NEDD8-activating enzyme inhibitor pevonedistat (TAK-924/MLN4924) in patients with metastatic melanoma..
34.
2016
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Phase 1 study of APTO-253 HCl, an inducer of KLF4, in patients with advanced or metastatic solid tumors..
33.
2015
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Phase I study of XL281 (BMS-908662), a potent oral RAF kinase inhibitor, in patients with advanced solid tumors..
33.
2014
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Phase I dose-escalation study of SGN-75 in patients with CD70-positive relapsed/refractory non-Hodgkin lymphoma or metastatic renal cell carcinoma..
32.
2014
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Targeting DNA repair with combination veliparib (ABT-888) and temozolomide in patients with metastatic castration-resistant prostate cancer..
32.
2014
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A phase II study of pralatrexate with vitamin B12 and folic acid supplementation for previously treated recurrent and/or metastatic head and neck squamous cell cancer..
32.
2014
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Phase II trial of bortezomib alone or in combination with irinotecan in patients with adenocarcinoma of the gastroesophageal junction or stomach..
32.
2014
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A phase II trial of AS1411 (a novel nucleolin-targeted DNA aptamer) in metastatic renal cell carcinoma..
32.
2013
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Bortezomib overcomes MGMT-related resistance of glioblastoma cell lines to temozolomide in a schedule-dependent manner..
31.
2013
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A phase 2 multicenter study of tivantinib (ARQ 197) monotherapy in patients with relapsed or refractory germ cell tumors..
31.
2013
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Using the neurotransmitter serotonin to target imaging agents to glioblastoma cells..
30.
2012
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Phase I/II study of pegylated arginine deiminase (ADI-PEG 20) in patients with advanced melanoma..
31.
2012
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A phase 1 study of a chimeric monoclonal antibody against interleukin-6, siltuximab, combined with docetaxel in patients with metastatic castration-resistant prostate cancer..
31.
2012
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Phase I pharmacokinetic and pharmacodynamic study of cetuximab, irinotecan and sorafenib in advanced colorectal cancer..
31.
2012
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Phase I clinical, pharmacokinetic, and pharmacodynamic study of KOS-862 (Epothilone D) in patients with advanced solid tumors and lymphoma..
30.
2011
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A phase I study of subcutaneously administered aflibercept (VEGF trap) in a new formulation in patients with advanced solid tumors..
30.
2011
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A phase 1 study of KOS-862 (Epothilone D) co-administered with carboplatin (Paraplatin®) in patients with advanced solid tumors..
30.
2011
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A retrospective pooled analysis of trabectedin safety in 1,132 patients with solid tumors treated in phase II clinical trials..
30.
2011
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Clinical and pharmacologic evaluation of two dose levels of intetumumab (CNTO 95) in patients with melanoma or angiosarcoma..
30.
2011
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Phase II study of cilengitide (EMD 121974, NSC 707544) in patients with non-metastatic castration resistant prostate cancer, NCI-6735. A study by the DOD/PCF prostate cancer clinical trials consortium..
30.
2010
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Phase II trial of sunitinib in patients with metastatic non-clear cell renal cell carcinoma..
30.
2010
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A pilot phase II trial of all-trans retinoic acid (Vesanoid) and paclitaxel (Taxol) in patients with recurrent or metastatic breast cancer..
29.
2010
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A multicenter, phase II study of bortezomib (PS-341) in patients with unresectable or metastatic gastric and gastroesophageal junction adenocarcinoma..
29.
2010
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A phase I pharmacokinetic study of pulse-dose vorinostat with flavopiridol in solid tumors..
29.
2010
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A phase II multicenter study of ipilimumab with or without dacarbazine in chemotherapy-naïve patients with advanced melanoma..
29.
2010
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Phase II trial of sunitinib in patients with relapsed or refractory germ cell tumors..
28.
2009
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Regression of Dalton's lymphoma in vivo via decline in lactate dehydrogenase and induction of apoptosis by a ruthenium(II)-complex containing 4-carboxy N-ethylbenzamide as ligand..
27.
2008
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Phase I trial of weekly cisplatin, irinotecan and paclitaxel in patients with advanced gastrointestinal cancer..
27.
2008
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Phase I study of the ribonucleotide reductase inhibitor 3-aminopyridine-2-carboxaldehyde-thiosemicarbazone (3-AP) in combination with high dose cytarabine in patients with advanced myeloid leukemia..
26.
2008
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Phase II trial of lenalidomide in patients with metastatic renal cell carcinoma..
26.
2007
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The pharmacokinetics, toxicities, and biologic effects of FK866, a nicotinamide adenine dinucleotide biosynthesis inhibitor..
26.
2007
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Phase II trial of ixabepilone in patients with cisplatin-refractory germ cell tumors..
25.
2007
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A phase I trial of BMS-247550 (NSC# 710428) and gemcitabine in patients with advanced solid tumors..
25.
2007
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Phase II trial of pemetrexed as second-line therapy in patients with metastatic urothelial carcinoma..
25.
2006
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A phase II trial of 17-(Allylamino)-17-demethoxygeldanamycin in patients with papillary and clear cell renal cell carcinoma..
24.
2006
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A Phase II study of SU5416 in patients with advanced or recurrent head and neck cancers..
25.
2006
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A multi-center phase II study of BMS-247550 (Ixabepilone) by two schedules in patients with metastatic gastric adenocarcinoma previously treated with a taxane..
24.
2006
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Phase I/II trial of gemcitabine plus docetaxel in advanced non small cell lung cancer (NSCLC)..
22.
2004
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Phase II trial of temozolomide in patients with cisplatin-refractory germ cell tumors..
22.
2004
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A phase II study of intravenous exatecan mesylate (DX-8951f) administered daily for five days every three weeks to patients with metastatic adenocarcinoma of the colon or rectum..
22.
2004
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Subcutaneously administered recombinant human interleukin-2 and interferon alfa-2a for advanced breast cancer: a phase II study of the Cancer and Leukemia Group B (CALGB 9041)..
22.
2004
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Phase II trial of ZD1839 (IRESSA) in patients with advanced renal cell carcinoma..
21.
2003
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Phase II trial of antiepidermal growth factor receptor antibody C225 in patients with advanced renal cell carcinoma..
21.
2003
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Phase II trial of arsenic trioxide in patients with metastatic renal cell carcinoma..
20.
2002
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A phase II trial of bryostatin-1 in patients with metastatic or recurrent squamous cell carcinoma of the head and neck..
20.
2002
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A phase I trial of the oral platinum analogue JM216 with concomitant radiotherapy in advanced malignancies of the chest..
19.
2001
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A phase II trial of 9-aminocaptothecin (9-AC) as a 120-h infusion in patients with non-small cell lung cancer..
19.
2001
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Phase II trial of irofulven (6-hydroxymethylacylfulvene) for patients with advanced renal cell carcinoma..
19.
2001
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Phase II trial of pyrazoloacridine as second-line therapy for patients with unresectable or metastatic transitional cell carcinoma..
18.
2000
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Phase II trial of pyrazoloacridine in patients with cisplatin-refractory germ cell tumors..
18.
2000
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A phase II study of pyrazoloacridine in patients with advanced renal cell carcinoma..
16.
1998
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A phase I trial and pharmacokinetic evaluation of CI-980 in patients with advanced solid tumors..
15.
1997
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A phase II study of 13-cis-retinoic acid in patients with advanced renal cell carcinoma..
15.
1997
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Phase II study of elsamitrucin (BMY-28090) for the treatment of patients with refractory/relapsed non-Hodgkin's lymphoma..
14.
1996
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Phase II trial of topotecan in patients with cisplatin-refractory germ cell tumors..
13.
1995
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Phase II trial of gemcitabine (2,2'-difluorodeoxycytidine) in patients with adenocarcinoma of the pancreas..
12.
1994
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Phase II trial of liposomal encapsulated doxorubicin in patients with advanced renal cell carcinoma..
12.
1994
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Phase II trial of topotecan in patients with advanced renal cell carcinoma..
12.
1994
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A phase II trial of deoxyspergualin in recurrent squamous cell head and neck cancer..
11.
1993
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Phase II trial of gallium nitrate in previously treated patients with small cell lung cancer..
11.
1993
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A phase II trial of CI-921 in advanced malignancies..
10.
1992
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Phase II study of iproplatin (CHIP) in patients with cisplatin-refractory germ cell tumors; the need for alternative strategies in the investigation of new agents in GCT..
10.
1992
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Phase II trial of edatrexate in patients with advanced pancreatic adenocarcinoma..
10.
1992
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Phase II trial of fazarabine (arabinofuranosyl-5-azacytidine) in patients with advanced pancreatic adenocarcinoma..
10.
1992
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Menogaril in the treatment of malignant mesothelioma: a phase II study..
10.
1992
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Phase II trial of esorubicin (4'deoxydoxorubicin, DxDx) in patients with small cell lung cancer..
9.
1991
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Phase II trial of N-methylformamide in patients with metastatic melanoma..
9.
1991
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Phase II trial of cisplatin and etoposide in patients with metastatic melanoma..
9.
1991
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4'-EPI-doxorubicin in advanced lung cancer. A phase II trial..
8.
1990
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Phase II trial of Didemnin B in patients with advanced renal cell carcinoma..
8.
1990
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Phase II trial of carboplatin and vinblastine in adenocarcinoma of the stomach..
8.
1990
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Phase II trial of carboplatin in patients with advanced melanoma..
8.
1990
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Phase II study of CHIP chemotherapy in advanced adenocarcinomas of the upper gastrointestinal tract..
8.
1990
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A phase I trial of intraperitoneal recombinant interleukin 2 in patients with ovarian carcinoma..
6.
1988
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Phase II trial of ifosfamide in epidermoid carcinoma of the esophagus: unexpectant severe toxicity..
6.
1988
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Phase II trial of 10 deaza-aminopterin in patients with bladder cancer..
4.
1986
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The risk of hand-foot skin reaction to axitinib, a novel VEGF inhibitor: a systematic review of literature and meta-analysis.
2013
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The risk of hand foot skin reaction to pazopanib, a novel multikinase inhibitor: a systematic review of literature and meta-analysis.
2011
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