A review of endothelial dysfunction in diabetes: a focus on the contribution of a dysfunctional eNOS. Review uri icon

Overview

abstract

  • Although the etiology of vascular dysfunction in diabetes has been extensively investigated in both humans as well as animal models of human diabetes, the relative importance of the cellular pathways involved is still not fully understood. In this review, we focus on reviewing the literature that provides insights into how an acute exposure to hyperglycemia results in a dysregulation of endothelial nitric oxide synthase function, the subsequent downstream effects of endothelial nitric oxide synthase dysregulation, and the development of endothelial dysfunction.

publication date

  • May 1, 2010

Research

keywords

  • Diabetes Mellitus
  • Endothelium, Vascular
  • Nitric Oxide Synthase Type III
  • Vasoconstriction

Identity

Scopus Document Identifier

  • 77954724449

Digital Object Identifier (DOI)

  • 10.1016/j.jash.2010.02.004

PubMed ID

  • 20470995

Additional Document Info

volume

  • 4

issue

  • 3