Triggle, Christopher Robert

Publications

Sort by

Co-Author Network

selected publications

Metformin-loaded nanoparticles reduce hyperglycemia-associated oxidative stress and induce eNOS phosphorylation in vascular endothelial cells. Scientific reports. 2024 Academic Article GET IT
Times cited: 2
Repurposing Metformin for the Treatment of Atrial Fibrillation: Current Insights. Vascular health and risk management. 2024 Review GET IT
Alzheimer's disease and its treatment-yesterday, today, and tomorrow. Frontiers in pharmacology. 2024 Review GET IT
Times cited: 48
The Effect of Different Glucose Concentrations on the Antiproliferative Activity of Metformin in MCF-7 Breast Cancer Cells. Pharmaceutics. 2023 Academic Article GET IT
Times cited: 4
Metabolic heterogeneity in TNBCs: A potential determinant of therapeutic efficacy of 2-deoxyglucose and metformin combinatory therapy. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Academic Article GET IT
Repurposing Metformin for Vascular Disease. Current medicinal chemistry. 2023 Review GET IT
Times cited: 17
Biofunctionalization of cardiovascular stents to induce endothelialization: Implications for in- stent thrombosis in diabetes. Frontiers in pharmacology. 2022 Review GET IT
Times cited: 9
Metformin: Is it a drug for all reasons and diseases?. Metabolism: clinical and experimental. 2022 Review GET IT
Times cited: 176
Matching Drug Metabolites from Non-Targeted Metabolomics to Self-Reported Medication in the Qatar Biobank Study. Metabolites. 2022 Academic Article GET IT
Times cited: 12
3D Tissue-Engineered Vascular Drug Screening Platforms: Promise and Considerations. Frontiers in cardiovascular medicine. 2022 Review GET IT
Times cited: 34
Angiogenic content of microparticles in patients with diabetes and coronary artery disease predicts networks of endothelial dysfunction. Cardiovascular diabetology. 2022 Academic Article GET IT
Times cited: 21
Metformin Prevents Hyperglycemia-Associated, Oxidative Stress-Induced Vascular Endothelial Dysfunction: Essential Role for the Orphan Nuclear Receptor Human Nuclear Receptor 4A1 (Nur77). Molecular pharmacology. 2021 Academic Article GET IT
Times cited: 25
A Critical Review of the Evidence That Metformin Is a Putative Anti-Aging Drug That Enhances Healthspan and Extends Lifespan. Frontiers in endocrinology. 2021 Review GET IT
Times cited: 209
Requiem for impact factors and high publication charges. Accountability in research. 2021 Review GET IT
Times cited: 31
A Comprehensive Review of Viral Characteristics, Transmission, Pathophysiology, Immune Response, and Management of SARS-CoV-2 and COVID-19 as a Basis for Controlling the Pandemic. Frontiers in immunology. 2021 Information Resource GET IT
Times cited: 127
A Review of the Progress and Challenges of Developing a Vaccine for COVID-19. Frontiers in immunology. 2020 Information Resource GET IT
Times cited: 403
Why the endothelium? The endothelium as a target to reduce diabetes-associated vascular disease. Canadian journal of physiology and pharmacology. 2020 Review GET IT
Times cited: 42
Metformin: The Answer to Cancer in a Flower? Current Knowledge and Future Prospects of Metformin as an Anti-Cancer Agent in Breast Cancer. Biomolecules. 2019 Information Resource GET IT
Times cited: 71
Treatment with a Combination of Metformin and 2-Deoxyglucose Upregulates Thrombospondin-1 in Microvascular Endothelial Cells: Implications in Anti-Angiogenic Cancer Therapy. Cancers. 2019 Academic Article GET IT
Times cited: 28
Potent and PPARα-independent anti-proliferative action of the hypolipidemic drug fenofibrate in VEGF-dependent angiosarcomas in vitro. Scientific reports. 2019 Academic Article GET IT
Times cited: 15
Exercise Alleviates Obesity-Induced Metabolic Dysfunction via Enhancing FGF21 Sensitivity in Adipose Tissues. Cell reports. 2019 Academic Article GET IT
Times cited: 158
Minimizing Hyperglycemia-Induced Vascular Endothelial Dysfunction by Inhibiting Endothelial Sodium-Glucose Cotransporter 2 and Attenuating Oxidative Stress: Implications for Treating Individuals With Type 2 Diabetes. Canadian journal of diabetes. 2019 Academic Article GET IT
Times cited: 29
Impact of currently used anti-diabetic drugs on myoendothelial communication. Current opinion in pharmacology. 2018 Review GET IT
Times cited: 8
Hyperglycaemic impairment of PAR2-mediated vasodilation: Prevention by inhibition of aortic endothelial sodium-glucose-co-Transporter-2 and minimizing oxidative stress. Vascular pharmacology. 2018 Academic Article GET IT
Times cited: 107
Hyperglycaemia disrupts conducted vasodilation in the resistance vasculature of db/db mice. Vascular pharmacology. 2018 Academic Article GET IT
Times cited: 15
Effects of oxidative and thermal stresses on stress granule formation in human induced pluripotent stem cells. PloS one. 2017 Academic Article GET IT
Times cited: 26
Metformin represses glucose starvation induced autophagic response in microvascular endothelial cells and promotes cell death. Biochemical pharmacology. 2017 Academic Article GET IT
Times cited: 22
From Gutenberg to Open Science: An Unfulfilled Odyssey. Drug development research. 2016 Academic Article GET IT
Times cited: 17
Metformin is not just an antihyperglycaemic drug but also has protective effects on the vascular endothelium. Acta physiologica (Oxford, England). 2016 Review GET IT
Times cited: 86
Molecular Interplay between microRNA-34a and Sirtuin1 in Hyperglycemia-Mediated Impaired Angiogenesis in Endothelial Cells: Effects of Metformin. The Journal of pharmacology and experimental therapeutics. 2015 Academic Article GET IT
Times cited: 55
Metformin improves endothelial function in aortic tissue and microvascular endothelial cells subjected to diabetic hyperglycaemic conditions. Biochemical pharmacology. 2015 Academic Article GET IT
Times cited: 40
A Festschrift in honor of David J. Triggle. Biochemical pharmacology. 2015 Editorial Article GET IT
Challenges in the Biomedical Research Enterprise in the 21st century: Antecedents in the writings of David Triggle. Biochemical pharmacology. 2015 Review GET IT
Times cited: 5
The answer is not 42. Biochemical pharmacology. 2015 Review GET IT
Times cited: 4
Metformin: An Old Drug for the Treatment of Diabetes but a New Drug for the Protection of the Endothelium. Medical principles and practice : international journal of the Kuwait University, Health Science Centre. 2015 Review GET IT
Times cited: 159
MicroRNA Signature and Cardiovascular Dysfunction. Journal of cardiovascular pharmacology. 2015 Review GET IT
Times cited: 38
Fibroblast growth factor 21 prevents atherosclerosis by suppression of hepatic sterol regulatory element-binding protein-2 and induction of adiponectin in mice. Circulation. 2015 Academic Article GET IT
Times cited: 242
Cardiovascular impact of drugs used in the treatment of diabetes. Therapeutic advances in chronic disease. 2014 Review GET IT
Times cited: 49
FGF21 maintains glucose homeostasis by mediating the cross talk between liver and brain during prolonged fasting. Diabetes. 2014 Academic Article GET IT
Times cited: 234
Proteinase-activated receptors 1 and 2 and the regulation of porcine coronary artery contractility: a role for distinct tyrosine kinase pathways. British journal of pharmacology. 2014 Academic Article GET IT
Times cited: 12
Metformin modulates hyperglycaemia-induced endothelial senescence and apoptosis through SIRT1. British journal of pharmacology. 2014 Academic Article GET IT
Times cited: 200
The contribution of d-tubocurarine-sensitive and apamin-sensitive K-channels to EDHF-mediated relaxation of mesenteric arteries from eNOS-/- mice. Journal of cardiovascular pharmacology. 2012 Academic Article GET IT
Times cited: 1
Endothelial dysfunction in diabetes mellitus: possible involvement of endoplasmic reticulum stress?. Experimental diabetes research. 2012 Information Resource GET IT
Times cited: 105
Perivascular adipose tissue-derived relaxing factors: release by peptide agonists via proteinase-activated receptor-2 (PAR2) and non-PAR2 mechanisms. British journal of pharmacology. 2011 Academic Article GET IT
Times cited: 17
The endothelium in compliance and resistance vessels. Frontiers in bioscience (Scholar edition). 2011 Review GET IT
Times cited: 24
Endothelial dysfunction in diabetes: multiple targets for treatment. Pflugers Archiv : European journal of physiology. 2010 Review GET IT
Times cited: 89
A review of endothelial dysfunction in diabetes: a focus on the contribution of a dysfunctional eNOS. Journal of the American Society of Hypertension : JASH. 2010 Review GET IT
Times cited: 91
Endothelium-dependent vasodilation in myogenically active mouse skeletal muscle arterioles: role of EDH and K(+) channels. Microcirculation (New York, N.Y. : 1994). 2009 Academic Article GET IT
Times cited: 20
A role for nitroxyl (HNO) as an endothelium-derived relaxing and hyperpolarizing factor in resistance arteries. British journal of pharmacology. 2009 Academic Article GET IT
Times cited: 97
Effects of a Western diet versus high glucose on endothelium-dependent relaxation in murine micro- and macro-vasculature. European journal of pharmacology. 2008 Academic Article GET IT
Times cited: 28
Defying the economists: a decrease in heart rate improves not only cardiac but also endothelial function. British journal of pharmacology. 2008 Academic Article GET IT
Times cited: 14
Reduced EDHF responses and connexin activity in mesenteric arteries from the insulin-resistant obese Zucker rat. Diabetologia. 2008 Academic Article GET IT
Times cited: 43
The early effects of elevated glucose on endothelial function as a target in the treatment of type 2 diabetes. Timely topics in medicine. Cardiovascular diseases. 2008 Review GET IT
Times cited: 7
The early effects of elevated glucose on endothelial function as a target in the treatment of type 2 diabetes. Drugs of today (Barcelona, Spain : 1998). 2007 Review GET IT
Times cited: 8
Oxidative stress and increased eNOS and NADPH oxidase expression in mouse microvessel endothelial cells. Journal of cellular physiology. 2007 Academic Article GET IT
Times cited: 90
Increased oxidative stress in the streptozotocin-induced diabetic apoE-deficient mouse: changes in expression of NADPH oxidase subunits and eNOS. European journal of pharmacology. 2007 Academic Article GET IT
Times cited: 69
Calcium-activated potassium channel and connexin expression in small mesenteric arteries from eNOS-deficient (eNOS-/-) and eNOS-expressing (eNOS+/+) mice. European journal of pharmacology. 2007 Academic Article GET IT
Times cited: 17
Nitrosothiol stores in vascular tissue: modulation by ultraviolet light, acetylcholine and ionomycin. European journal of pharmacology. 2007 Academic Article GET IT
Times cited: 26
Vascular dysfunction in type 2 diabetic TallyHo mice: role for an increase in the contribution of PGH2/TxA2 receptor activation and cytochrome p450 products. Canadian journal of physiology and pharmacology. 2007 Academic Article GET IT
Times cited: 20
What is the future of peer review? Why is there fraud in science? Is plagiarism out of control? Why do scientists do bad things? Is it all a case of: "all that is necessary for the triumph of evil is that good men do nothing"?. Vascular health and risk management. 2007 Review GET IT
Times cited: 67
Pharmacological characteristics of endothelium-derived hyperpolarizing factor-mediated relaxation of small mesenteric arteries from db/db mice. European journal of pharmacology. 2006 Academic Article GET IT
Times cited: 45
Widespread vascular production of C-reactive protein (CRP) and a relationship between serum CRP, plaque CRP and intimal hypertrophy. Atherosclerosis. 2006 Academic Article GET IT
Times cited: 34
Novel role for K+-dependent Na+/Ca2+ exchangers in regulation of cytoplasmic free Ca2+ and contractility in arterial smooth muscle. American journal of physiology. Heart and circulatory physiology. 2006 Academic Article GET IT
Times cited: 40
Endothelial dysfunction in the streptozotocin-induced diabetic apoE-deficient mouse. British journal of pharmacology. 2005 Academic Article GET IT
Times cited: 90
A nonthiazolidinedione peroxisome proliferator-activated receptor gamma agonist reverses endothelial dysfunction in diabetic (db/db-/-) mice. The Journal of pharmacology and experimental therapeutics. 2005 Academic Article GET IT
Times cited: 9
Enhanced vascular reactivity of small mesenteric arteries from diabetic mice is associated with enhanced oxidative stress and cyclooxygenase products. British journal of pharmacology. 2005 Academic Article GET IT
Times cited: 80
Endothelial dysfunction in Type 2 diabetes correlates with deregulated expression of the tail-anchored membrane protein SLMAP. American journal of physiology. Heart and circulatory physiology. 2005 Academic Article GET IT
Times cited: 20
The vascular endothelium in diabetes: a practical target for drug treatment?. Expert opinion on therapeutic targets. 2005 Review GET IT
Times cited: 20
Are we over oxidized? Oxidative stress, cardiovascular disease, and the future of intervention studies with antioxidants. Vascular health and risk management. 2005 Academic Article GET IT
Times cited: 25
Cytochrome P450 products and arachidonic acid-induced, non-store-operated, Ca2+ entry in cultured bovine endothelial cells. Endothelium : journal of endothelial cell research. 2005 Academic Article GET IT
Times cited: 6
Endothelial cell dysfunction and the vascular complications associated with type 2 diabetes: assessing the health of the endothelium. Vascular health and risk management. 2005 Review GET IT
Times cited: 102
Twenty-five years since the discovery of endothelium-derived relaxing factor (EDRF): does a dysfunctional endothelium contribute to the development of type 2 diabetes?. Canadian journal of physiology and pharmacology. 2005 Review GET IT
Times cited: 21
Hyperpolarization of murine small caliber mesenteric arteries by activation of endothelial proteinase-activated receptor 2. Canadian journal of physiology and pharmacology. 2004 Academic Article GET IT
Times cited: 29
The endothelium in health and disease: A discussion of the contribution of non-nitric oxide endothelium-derived vasoactive mediators to vascular homeostasis in normal vessels and in type II diabetes. Molecular and cellular biochemistry. 2004 Academic Article GET IT
Times cited: 33
The endothelium in health and disease: a discussion of the contribution of non-nitric oxide endothelium-derived vasoactive mediators to vascular homeostasis in normal vessels and in type II diabetes. Molecular and cellular biochemistry. 2004 Review GET IT
Times cited: 33
2-furoyl-LIGRLO-amide: a potent and selective proteinase-activated receptor 2 agonist. The Journal of pharmacology and experimental therapeutics. 2004 Academic Article GET IT
Times cited: 123
The endothelium in health and disease--a target for therapeutic intervention. Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi. 2003 Review GET IT
Times cited: 96
Catalase has negligible inhibitory effects on endothelium-dependent relaxations in mouse isolated aorta and small mesenteric artery. British journal of pharmacology. 2003 Academic Article GET IT
Times cited: 56
Endothelium-derived reactive oxygen species: their relationship to endothelium-dependent hyperpolarization and vascular tone. Canadian journal of physiology and pharmacology. 2003 Review GET IT
Times cited: 72
Chronic oral supplementation with sepiapterin prevents endothelial dysfunction and oxidative stress in small mesenteric arteries from diabetic (db/db) mice. British journal of pharmacology. 2003 Academic Article GET IT
Times cited: 81
A photosensitive vascular smooth muscle store of nitric oxide in mouse aorta: no dependence on expression of endothelial nitric oxide synthase. British journal of pharmacology. 2003 Academic Article GET IT
Times cited: 28
Proteinase-activated receptor-2 (PAR2): vascular effects of a PAR2-derived activating peptide via a receptor different than PAR2. The Journal of pharmacology and experimental therapeutics. 2002 Academic Article GET IT
Times cited: 40
NO and the vasculature: where does it come from and what does it do?. Heart failure reviews. 2002 Review GET IT
Times cited: 25
Cellular basis of endothelial dysfunction in small mesenteric arteries from spontaneously diabetic (db/db -/-) mice: role of decreased tetrahydrobiopterin bioavailability. British journal of pharmacology. 2002 Academic Article GET IT
Times cited: 151
Endothelin blockade potentiates endothelial protective effects of ACE inhibitors in saphenous veins. The Annals of thoracic surgery. 2002 Academic Article GET IT
Times cited: 13
Endothelium-derived hyperpolarizing factor: is there a novel chemical mediator?. Clinical and experimental pharmacology & physiology. 2002 Review GET IT
Times cited: 39
Multiple mechanisms of vascular smooth muscle relaxation by the activation of proteinase-activated receptor 2 in mouse mesenteric arterioles. British journal of pharmacology. 2002 Academic Article GET IT
Times cited: 75
Vascular smooth muscle relaxation mediated by nitric oxide donors: a comparison with acetylcholine, nitric oxide and nitroxyl ion. British journal of pharmacology. 2001 Academic Article GET IT
Times cited: 114
State-dependent block of rabbit vascular smooth muscle delayed rectifier and Kv1.5 channels by inhibitors of cytochrome P450-dependent enzymes. The Journal of pharmacology and experimental therapeutics. 2001 Academic Article GET IT
Times cited: 13
Vasorelaxant effects of a nitric oxide-releasing aspirin derivative in normotensive and hypertensive rats. British journal of pharmacology. 2001 Academic Article GET IT
Times cited: 71
Endothelium-derived relaxing factors: a focus on endothelium-derived hyperpolarizing factor(s). Canadian journal of physiology and pharmacology. 2001 Review GET IT
Times cited: 162
Augmentation of endothelial function by endothelin antagonism in human saphenous vein conduits. Journal of neurosurgery. 2001 Academic Article GET IT
Times cited: 9
Endothelin receptor blockade improves endothelial function in human internal mammary arteries. Cardiovascular research. 2001 Academic Article GET IT
Times cited: 41
Lack of involvement of endothelin-1 in angiotensin II-induced contraction of the isolated rat tail artery. British journal of pharmacology. 2000 Academic Article GET IT
Times cited: 5
Nitric oxide and sodium nitroprusside-induced relaxation of the human umbilical artery. British journal of pharmacology. 2000 Academic Article GET IT
Times cited: 60
Tetrahydrobiopterin improves endothelial function in human saphenous veins. The Journal of thoracic and cardiovascular surgery. 2000 Academic Article GET IT
Times cited: 37
Antihypertensive properties of a nitric oxide-releasing naproxen derivative in two-kidney, one-clip rats. American journal of physiology. Heart and circulatory physiology. 2000 Academic Article GET IT
Times cited: 47
Comparison of the pharmacological properties of EDHF-mediated vasorelaxation in guinea-pig cerebral and mesenteric resistance vessels. British journal of pharmacology. 2000 Academic Article GET IT
Times cited: 49
Selective cyclo-oxygenase-2 inhibition with celecoxib elevates blood pressure and promotes leukocyte adherence. British journal of pharmacology. 2000 Academic Article GET IT
Times cited: 129
Potassium- and acetylcholine-induced vasorelaxation in mice lacking endothelial nitric oxide synthase. British journal of pharmacology. 2000 Academic Article GET IT
Times cited: 67
Novel endothelium-derived relaxing factors. Identification of factors and cellular targets. Journal of pharmacological and toxicological methods. 2000 Review GET IT
Times cited: 25
Acetylcholine-induced relaxation of peripheral arteries isolated from mice lacking endothelial nitric oxide synthase. British journal of pharmacology. 1999 Academic Article GET IT
Times cited: 117
Functional characterization and m-RNA expression of 5-HT receptors mediating contraction in human umbilical artery. British journal of pharmacology. 1999 Academic Article GET IT
Times cited: 35
Endothelium-derived hyperpolarizing factor(s): species and tissue heterogeneity. Clinical and experimental pharmacology & physiology. 1999 Academic Article GET IT
Times cited: 49
The future of pharmacology in Canada. Proceedings of the Western Pharmacology Society. 1999 Academic Article GET IT
Endothelium-dependent contractile actions of proteinase-activated receptor-2-activating peptides in human umbilical vein: release of a contracting factor via a novel receptor. British journal of pharmacology. 1998 Academic Article GET IT
Times cited: 40
Cyclic GMP-dependent and cyclic GMP-independent actions of nitric oxide on the renal afferent arteriole. British journal of pharmacology. 1998 Academic Article GET IT
Times cited: 34
h1- and h2-calponins are not essential for norepinephrine- or sodium fluoride-induced contraction of rat aortic smooth muscle. Journal of muscle research and cell motility. 1998 Academic Article GET IT
Times cited: 33
Involvement of nitrosothiols, nitric oxide and voltage-gated K+ channels in photorelaxation of vascular smooth muscle. European journal of pharmacology. 1998 Academic Article GET IT
Times cited: 38
Dual endothelium-dependent vascular activities of proteinase-activated receptor-2-activating peptides: evidence for receptor heterogeneity. British journal of pharmacology. 1998 Academic Article GET IT
Times cited: 49
Roles of calcium-activated and voltage-gated delayed rectifier potassium channels in endothelium-dependent vasorelaxation of the rabbit middle cerebral artery. British journal of pharmacology. 1998 Academic Article GET IT
Times cited: 61
Cardiovascular effects of CPU-23, a novel L-type calcium channel blocker with a unique molecular structure. British journal of pharmacology. 1997 Academic Article GET IT
Times cited: 5
NO/PGI2-independent vasorelaxation and the cytochrome P450 pathway in rabbit carotid artery. British journal of pharmacology. 1997 Academic Article GET IT
Times cited: 72
Endothelium-dependent contractile effect of trypsin-activated receptor (PAR2) stimulation in rat vascular tissue. Proceedings of the Western Pharmacology Society. 1997 Academic Article GET IT
Times cited: 1
Nitric oxide, a possible mediator of 1,4-dihydropyridine-induced photorelaxation of vascular smooth muscle. British journal of pharmacology. 1996 Academic Article GET IT
Times cited: 11
Interleukin-1beta, tumor necrosis factor-alpha, and LPS enhance calcium channel current in isolated vascular smooth muscle cells of rat tail artery. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 1996 Academic Article GET IT
Times cited: 50
Endothelium-dependent hyperpolarization of vascular smooth muscle: role for a non-nitric oxide synthase product. Zhongguo yao li xue bao = Acta pharmacologica Sinica. 1996 Review GET IT
Times cited: 21
Photosensitization of oesophageal smooth muscle by 3-NO2-1, 4-dihydropyridines: evidence for two cyclic GMP-dependent effector pathways. British journal of pharmacology. 1995 Academic Article GET IT
Times cited: 5
Vascular alpha-adrenoceptors: from the gene to the human. Canadian journal of physiology and pharmacology. 1995 Review GET IT
Times cited: 62
The endothelium contributes to the contractile responses of the human umbilical artery to 5-hydroxytryptamine and endothelin-1 under low but not high PO2 conditions. Canadian journal of physiology and pharmacology. 1994 Academic Article GET IT
Times cited: 5
Mechanism of bile salt vasoactivity: dependence on calcium channels in vascular smooth muscle. British journal of pharmacology. 1994 Academic Article GET IT
Times cited: 31
Competitive binding experiments reveal differential interactions for dihydropyridine calcium channel activators and antagonists at dihydropyridine receptors on mouse brain membranes. Canadian journal of physiology and pharmacology. 1994 Academic Article GET IT
Times cited: 1
Role of NO in vascular smooth muscle and cardiac muscle function. Trends in pharmacological sciences. 1994 Review GET IT
Times cited: 99
Pressor responses to the alpha 1-adrenoceptor agonist cirazoline: effects of captopril, phenoxybenzamine and nifedipine. European journal of pharmacology. 1994 Academic Article GET IT
Times cited: 3
Acetylcholine relaxes the human umbilical artery by an endothelium-independent but ouabain and tetraethylammonium-sensitive process. Proceedings of the Western Pharmacology Society. 1994 Academic Article GET IT
Times cited: 2
Endothelium-independent relaxations to acetylcholine and A23187 in the human umbilical artery. Journal of vascular research. 1994 Academic Article GET IT
Times cited: 29
The effects of perfusion rate and NG-nitro-L-arginine methyl ester on cirazoline- and KCl-induced responses in the perfused mesenteric arterial bed of rats. British journal of pharmacology. 1994 Academic Article GET IT
Times cited: 38
Computerized data acquisition and analysis applied to chemiluminescence detection of nitric oxide in headspace gas. Journal of pharmacological and toxicological methods. 1993 Academic Article GET IT
Times cited: 11
The effects of alpha-adrenoceptor agonists on intracellular Ca2+ levels in freshly dispersed single smooth muscle cells from rat tail artery. British journal of pharmacology. 1993 Academic Article GET IT
Times cited: 13
Interactions of nitric oxide synthase inhibitors and dexamethasone with alpha-adrenoceptor-mediated responses in rat aorta. British journal of pharmacology. 1993 Academic Article GET IT
Times cited: 33
Changes in vascular smooth muscle function in hypertension. Chinese medical journal. 1993 Academic Article GET IT
Times cited: 6
Varying extracellular [K+]: a functional approach to separating EDHF- and EDNO-related mechanisms in perfused rat mesenteric arterial bed. Journal of cardiovascular pharmacology. 1993 Academic Article GET IT
Times cited: 268
Effects of pertussis and cholera toxins on alpha-adrenoceptor function in rat tail artery: differences in hypertension. Canadian journal of physiology and pharmacology. 1993 Academic Article GET IT
Times cited: 17
Quantitation of nitric oxide by a computerized chemiluminescence detector measurement of photolytic degradation of streptozotocin and sodium nitroprusside to release nitric oxide. Proceedings of the Western Pharmacology Society. 1993 Academic Article GET IT
Times cited: 1
Pharmacological profile of the 5-hydroxytryptamine receptor that mediates relaxation of rat oesophageal smooth muscle. General pharmacology. 1992 Academic Article GET IT
Times cited: 15
A comparison of the effects of acute versus chronic administration of phenoxybenzamine on pressor responses elicited by the selective alpha 1-adrenoceptor agonist cirazoline in the pithed rat preparation. Canadian journal of physiology and pharmacology. 1992 Academic Article GET IT
Times cited: 2
The interrelationship between the effects of captopril and nifedipine on pressor responses elicited by selective alpha-adrenoceptor agonists in the pithed rat preparation. Journal of cardiovascular pharmacology. 1992 Academic Article GET IT
Times cited: 5
Actions of L- and D-arginine and NG-monomethyl-L-arginine on the blood pressure of pithed normotensive and spontaneously hypertensive rats. Clinical and experimental hypertension. Part A, Theory and practice. 1992 Academic Article GET IT
Times cited: 16
Alpha-mediated vasoconstriction: transmembrane signalling and receptor reclassification. Advances in experimental medicine and biology. 1992 Academic Article GET IT
Times cited: 1
Comparative effects of the K+ channel openers, pinacidil and cromakalim on vascular tone: sensitivity to glyburide and calcium. Proceedings of the Western Pharmacology Society. 1992 Academic Article GET IT
Times cited: 3
Pharmacological properties of acetylcholine mediated relaxation of the human umbilical artery. Proceedings of the Western Pharmacology Society. 1992 Academic Article GET IT
Role of guanylate cyclase activation in the smooth muscle actions of dihydropyridines. Advances in experimental medicine and biology. 1992 Academic Article GET IT
Times cited: 1
The effects of changes in pO2 on endothelium-dependent and -independent relaxations of the human umbilical artery and rat aorta. Advances in experimental medicine and biology. 1992 Academic Article GET IT
Vasopressin (V1) receptor characteristics in rat aortic smooth muscle cells. The American journal of physiology. 1991 Academic Article GET IT
Times cited: 31
Effects of some inorganic divalent cations and protein kinase C inhibitors on endothelium-dependent relaxation in rat isolated aorta and mesenteric arteries. Journal of cardiovascular pharmacology. 1991 Academic Article GET IT
Times cited: 14
Pressor actions of arginine vasopressin in pithed Sprague-Dawley, Wistar-Kyoto and spontaneously hypertensive rats before and after treatment with nifedipine or pertussis toxin. Journal of hypertension. 1991 Academic Article GET IT
Times cited: 10
Mechanism of vascular smooth muscle contraction by sodium fluoride in the isolated aorta of rat and rabbit. The Journal of pharmacology and experimental therapeutics. 1991 Academic Article GET IT
Times cited: 17
Effects of endothelin 3 on diastolic blood pressure of pithed Sprague-Dawley, Wistar Kyoto, and spontaneously hypertensive rats before and after pretreatment with nifedipine. Canadian journal of physiology and pharmacology. 1991 Academic Article GET IT
Times cited: 4
Prevention of hypertension and vascular changes by captopril treatment. Hypertension (Dallas, Tex. : 1979). 1991 Academic Article GET IT
Times cited: 125
A comparative study of endothelin and sarafotoxin action in vascular and non-vascular smooth muscle. Neurochemistry international. 1991 Academic Article GET IT
Times cited: 8
Effects of staurosporine on the pressor responses to alpha-adrenoceptor agonists in pithed rats: a comparison with nifedipine. Pharmacology. 1991 Academic Article GET IT
Influence of N omega-nitro-L-arginine methyl on pressor responses elicited by sympathetic nerve stimulation in pithed normotensive and hypertensive rats. Life sciences. 1991 Academic Article GET IT
Times cited: 18
Alpha-adrenoceptor activation of polyphosphoinositide hydrolysis in the rat tail artery. Biochemical pharmacology. 1990 Academic Article GET IT
Times cited: 15
Calcium, calcium channels, and calcium channel antagonists. Canadian journal of physiology and pharmacology. 1990 Review GET IT
Times cited: 85
Effects of nifedipine, BAY K 8644, and pertussis toxin on pressor response to sarafotoxin-b in pithed rats. Journal of cardiovascular pharmacology. 1990 Academic Article GET IT
Times cited: 1
Comparative behavioral, neurochemical and pharmacological activities of dihydropyridine calcium channel activating drugs. The Journal of pharmacology and experimental therapeutics. 1990 Academic Article GET IT
Times cited: 14
Calcium antagonizes the magnesium-induced high affinity state of the hepatic vasopressin receptor for the agonist interaction. British journal of pharmacology. 1990 Academic Article GET IT
Times cited: 3
Comparison between the vasoactive actions of endothelin and arginine vasopressin in pithed rats after pretreatment with BAY K 8644, nifedipine or pertussis toxin. The Journal of pharmacology and experimental therapeutics. 1990 Academic Article GET IT
Times cited: 14
Can dihydropyridines enhance photorelaxation of smooth muscle by calcium-independent mechanisms?. Proceedings of the Western Pharmacology Society. 1990 Academic Article GET IT
Times cited: 5
Comparative studies with enantiomers of dihydropyridine ligands suggests that there are multiple binding sites associated with the calcium channel. Proceedings of the Western Pharmacology Society. 1990 Academic Article GET IT
Times cited: 1
Studies of the desensitization of atrial natriuretic factor and nitroglycerin in rat aortic rings. General pharmacology. 1990 Academic Article GET IT
Times cited: 6
Lipids as endogenous Na,K-ATPase inhibitors in plasma of healthy individuals and in dialysis dependent patients. Clinical biochemistry. 1989 Academic Article GET IT
Times cited: 7
Benextramine and nifedipine distinguish between sub-classes of alpha 1-adrenoceptors. Life sciences. 1989 Academic Article GET IT
Times cited: 6
Alpha adrenoceptor sites in vascular smooth muscle. Differentiation by selective antagonist binding. Biochemical pharmacology. 1988 Academic Article GET IT
Times cited: 11
Inhibition of field stimulation-evoked relaxations in rat oesophageal smooth muscle by the calcium antagonist PN 200-110. British journal of pharmacology. 1988 Academic Article GET IT
Times cited: 4
Similarity of relaxations evoked by BRL 34915, pinacidil and field-stimulation in rat oesophageal tunica muscularis mucosae. British journal of pharmacology. 1988 Academic Article GET IT
Times cited: 6
Hepatic vasopressin receptor: differential effects of divalent cations, guanine nucleotides, and N-ethylmaleimide on agonist and antagonist interactions with the V1 subtype receptor. Endocrinology. 1988 Academic Article GET IT
Times cited: 22
Fura-2 used as a probe to show elevated intracellular free calcium in platelets of Dahl-sensitive rats fed a high salt diet. Biochemical and biophysical research communications. 1988 Academic Article GET IT
Times cited: 39
Synthesis and calcium channel antagonist activity of nifedipine analogues containing 1,2-dihydropyridyl in place of the 1,4-dihydropyridyl moiety. Drug design and delivery. 1988 Academic Article GET IT
Times cited: 3
Cardiac hypertrophy in experimental hypertension: interaction of the sodium ion, blood pressure and lisinopril. The Canadian journal of cardiology. 1988 Academic Article GET IT
Times cited: 5
Structural and functional consequence of neonatal sympathectomy on the blood vessels of spontaneously hypertensive rats. Hypertension (Dallas, Tex. : 1979). 1987 Academic Article GET IT
Times cited: 152
Synthesis and calcium channel antagonist activity of dialkyl 4- (dihydropyridinyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinecarboxylates. Journal of medicinal chemistry. 1987 Academic Article GET IT
Times cited: 51
Effects of cold storage on relaxation responses in the rat oesophageal tunica muscularis mucosae. Canadian journal of physiology and pharmacology. 1987 Academic Article GET IT
Times cited: 13
Chloride removal and excitation-contraction coupling in guinea pig ileal smooth muscle. Canadian journal of physiology and pharmacology. 1986 Academic Article GET IT
Times cited: 7
Synthesis and calcium channel antagonist activity of dialkyl 1,4-dihydro-2,6-dimethyl-4-(pyridinyl)-3,5-pyridinedicarboxylates. Journal of medicinal chemistry. 1986 Academic Article GET IT
Times cited: 55
Tetrodotoxin-sensitive and -insensitive relaxations in the rat oesophageal tunica muscularis mucosae. The Journal of physiology. 1986 Academic Article GET IT
Times cited: 15
Effects of noradrenaline, serotonin, and selected antagonists on the vascular smooth muscle of normal and dystrophic chickens. Canadian journal of physiology and pharmacology. 1986 Academic Article GET IT
Times cited: 1
Characterization of a specific, high affinity [3H]arginine8 vasopressin-binding site on liver microsomes from different strains of rat and the role of magnesium. Endocrinology. 1986 Academic Article GET IT
Times cited: 19
Subcellular membrane properties in vascular and non-vascular smooth muscles of Dahl hypertensive rats. Journal of hypertension. 1986 Academic Article GET IT
Times cited: 7
Morphometric study of mesenteric arteries from genetically hypertensive Dahl strain rats. Blood vessels. 1986 Academic Article GET IT
Times cited: 34
The effect of the calcium channel agonist, Bay K-8644 on human vascular smooth muscle. European journal of pharmacology. 1985 Academic Article GET IT
Times cited: 32
A review of changes in vascular smooth muscle functions in hypertension: isolated tissue versus in vivo studies. Canadian journal of physiology and pharmacology. 1985 Review GET IT
Times cited: 35
Hypertensive mechanisms: the role of altered smooth muscle and membrane function in the etiology of hypertension. Canadian journal of physiology and pharmacology. 1985 Academic Article GET IT
Times cited: 1
Modulation of right and left ventricular wall thicknesses in experimental hypertension. Clinical and investigative medicine. Medecine clinique et experimentale. 1985 Academic Article GET IT
Times cited: 2
Pharmacological properties of mechanical responses of the rat oesophageal muscularis mucosae to vagal and field stimulation. British journal of pharmacology. 1985 Academic Article GET IT
Times cited: 47
The reversal of left ventricular hypertrophy with control of blood pressure in experimental hypertension. Scandinavian journal of clinical and laboratory investigation. 1984 Academic Article GET IT
Times cited: 17
Specific high affinity binding of the calcium channel antagonist, [3H]nitrendipine, to rat liver microsomes. Canadian journal of physiology and pharmacology. 1984 Academic Article GET IT
Times cited: 5
Membrane fractionation of canine aortic smooth muscle: subcellular distribution of calcium transport activity. Journal of molecular and cellular cardiology. 1984 Academic Article GET IT
Times cited: 30
Systolic blood pressure responses to enalapril maleate (MK 421, an angiotensin converting enzyme inhibitor) and hydrochlorothiazide in conscious Dahl salt-sensitive and salt-resistant rats. Canadian journal of physiology and pharmacology. 1984 Academic Article GET IT
Times cited: 17
Pharmacological characterization of the postsynaptic alpha adrenoceptors in vascular smooth muscle from canine and rat mesenteric vascular beds. The Journal of pharmacology and experimental therapeutics. 1984 Academic Article GET IT
Times cited: 66
The effect of indomethacin on the duration of the hypotensive action of bradykinin in Dahl salt-resistant rats: role of cyclooxygenase inhibition. Prostaglandins, leukotrienes, and medicine. 1984 Academic Article GET IT
Times cited: 5
Differential sensitivity of Dahl salt-sensitive and Dahl salt-resistant rats to the hypotensive action of acute nifedipine administration. Canadian journal of physiology and pharmacology. 1984 Academic Article GET IT
Times cited: 26
Blood pressure, lanthanum-, and norepinephrine-induced mechanical response in thoracic aortic tissue. Hypertension (Dallas, Tex. : 1979). 1984 Academic Article GET IT
Times cited: 10
Pharmacological studies of smooth muscle from Dahl salt-sensitive and salt-resistant rats. Canadian journal of physiology and pharmacology. 1984 Academic Article GET IT
Times cited: 10
The relationship between the elevated blood pressure of the spontaneously hypertensive rat and the chemical sensitivity of smooth muscle to adrenergic agents. Canadian journal of physiology and pharmacology. 1984 Academic Article GET IT
Times cited: 8
Cardiac regression and blood pressure control in the Dahl rat treated with either enalapril maleate (MK 421, an angiotensin converting enzyme inhibitor) or hydrochlorothiazide. Journal of hypertension. 1983 Academic Article GET IT
Times cited: 34
On the oxalate stimulation of ATP-dependent calcium accumulation by smooth muscle subcellular membranes. Biochemistry international. 1983 Academic Article GET IT
Times cited: 7
The action of the ionophore ionomycin in guinea-pig intestinal smooth muscle. Canadian journal of physiology and pharmacology. 1983 Academic Article GET IT
Times cited: 2
Nature of norepinephrine-sensitive Ca-pool in rabbit aortic smooth muscle: effect of pH. Life sciences. 1983 Academic Article GET IT
Times cited: 13
An analytical approach to the preparation and characterization of subcellular membranes from canine mesenteric arteries. Preparative biochemistry. 1983 Academic Article GET IT
Times cited: 32
Regression of left ventricular hypertrophy and control of hypertension in the spontaneously hypertensive rat (SHR): oxprenolol versus hydrochlorothiazide. Clinical and investigative medicine. Medecine clinique et experimentale. 1983 Academic Article GET IT
Times cited: 7
Calcium-channel antagonist binding to isolated vascular smooth muscle membranes. Canadian journal of physiology and pharmacology. 1982 Academic Article GET IT
Times cited: 31
Chloride removal selectively inhibits phasic contractions of guinea pig ileal longitudinal smooth muscle. Canadian journal of physiology and pharmacology. 1982 Academic Article GET IT
Times cited: 7
Reactivity of vasa deferentia from spontaneously hypertensive and normotensive Wistar rats. Canadian journal of physiology and pharmacology. 1980 Academic Article GET IT
Times cited: 19
Calcium antagonists and contractile responses in rat vas deferens and guinea pig ileal smooth muscle. Canadian journal of physiology and pharmacology. 1979 Academic Article GET IT
Times cited: 67
Elevated vascular reactivity in the timolol-treated spontaneously hypertensive rat. Canadian journal of physiology and pharmacology. 1978 Academic Article GET IT
Times cited: 10
An analysis of the action of lanthanum on aortic tissue from normotensive and spontaneously hypertensive rats. Canadian journal of physiology and pharmacology. 1977 Academic Article GET IT
Times cited: 10
An analysis of the action of cations of the lanthanide series on the mechanical responses of guinea-pig ileal longitudinal muscle. The Journal of physiology. 1976 Academic Article GET IT
Times cited: 49
The effects of lanthanum and thulium on the mechanical responses of rat vas deferens. The Journal of physiology. 1976 Academic Article GET IT
Times cited: 17
The action of the ionophores, X-537A and A-23187, on smooth muscle. Canadian journal of physiology and pharmacology. 1975 Academic Article GET IT
Times cited: 16
Intestinal smooth muscle contraction and the effects of cadmium and A23187. The Journal of pharmacology and experimental therapeutics. 1975 Academic Article GET IT
Times cited: 25
Cocaine-induced supersensitivity in the human umbilical artery. Canadian journal of physiology and pharmacology. 1974 Academic Article GET IT
Times cited: 26
Some properties of noradrenaline uptake in non-innervated vascular smooth muscle. Canadian journal of physiology and pharmacology. 1974 Academic Article GET IT
Times cited: 1
Chemical responsiveness of single cortical neurones during entrainment of epileptiform after-discharges. The Journal of physiology. 1972 Academic Article GET IT
Times cited: 1
The mechanism of action of 2-halogenoethylamines at the adrenergic alpha-receptor and a further investigation of the "spare receptor" hypothesis. The Journal of pharmacy and pharmacology. 1969 Academic Article GET IT
Times cited: 24

more ...

less ...

Background

education and training

B.Sc., University of East Anglia (United Kingdom) 1967
Ph.D., University of Alberta (Canada) 1972

Contact

full name

Christopher Robert Triggle

primary email

cht2011@qatar-med.cornell.edu

VIVO Weill Cornell Medical College

Christopher Robert Triggle Professor of Pharmacology

Publications

selected publications

Background

education and training

Contact

full name

primary email