ATM: Promoter of metabolic "cost" reduction and "savings" usage during hypoxia through mTORC1 regulation.
Overview
abstract
Cells must sense environmental conditions and adjust to maintain metabolic homeostasis and survive stress conditions; in this issue, Cam et al. (2010) show that the tumor suppressor kinase ATM is activated by hypoxia, phosphorylates and stabilizes HIF-1α, and inhibits mTORC1.
