ATM: Promoter of metabolic "cost" reduction and "savings" usage during hypoxia through mTORC1 regulation.
Article
Overview
abstract
Cells must sense environmental conditions and adjust to maintain metabolic homeostasis and survive stress conditions; in this issue, Cam et al. (2010) show that the tumor suppressor kinase ATM is activated by hypoxia, phosphorylates and stabilizes HIF-1α, and inhibits mTORC1.
