Molecular cell
Journal
Overview
publication venue for
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3D chromatin hubs as regulatory units of identity and survival in human acute leukemia.
2024
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Mutability and hypermutation antagonize immunoglobulin codon optimality.
2024
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Nutrient control of growth and metabolism through mTORC1 regulation of mRNA splicing.
2024
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Opposing regulation of the STING pathway in hepatic stellate cells by NBR1 and p62 determines the progression of hepatocellular carcinoma.
2024
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Hexokinase 1 forms rings that regulate mitochondrial fission during energy stress.
2024
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GPATCH8 modulates mutant SF3B1 mis-splicing and pathogenicity in hematologic malignancies.
2024
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SRSF2 plays an unexpected role as reader of m5C on mRNA, linking epitranscriptomics to cancer..
83.
2023
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Locus-specific proteome decoding reveals Fpt1 as a chromatin-associated negative regulator of RNA polymerase III assembly..
83.
2023
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Ran-Binding Protein 3 Phosphorylation Links the Ras and PI3-Kinase Pathways to Nucleocytoplasmic Transport..
83.
2023
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Lactate activates the mitochondrial electron transport chain independently of its metabolism..
83.
2023
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The crosstalk between DNA repair and immune responses..
83.
2023
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FAM120A couples SREBP-dependent transcription and splicing of lipogenesis enzymes downstream of mTORC1..
83.
2023
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Chromatin regulation of transcriptional enhancers and cell fate by the Sotos syndrome gene NSD1..
83.
2023
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RBM33: A new regulator of N-6-methyladenosine (m6A) methylation..
83.
2023
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Proteomic discovery of chemical probes that perturb protein complexes in human cells..
83.
2023
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CDT1 inhibits CMG helicase in early S phase to separate origin licensing from DNA synthesis..
83.
2023
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D-2HG comes out of its shell: Metabolic effects on the immune environment..
82.
2022
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POLθ prevents MRE11-NBS1-CtIP-dependent fork breakage in the absence of BRCA2/RAD51 by filling lagging-strand gaps..
82.
2022
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Error-prone repair of stalled replication forks drives mutagenesis and loss of heterozygosity in haploinsufficient BRCA1 cells.
2022
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ARAF protein kinase activates RAS by antagonizing its binding to RASGAP NF1..
82.
2022
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Allosteric interactions prime androgen receptor dimerization and activation..
82.
2022
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Error-prone repair of stalled replication forks drives mutagenesis and loss of heterozygosity in haploinsufficient BRCA1 cells.
82:3781-3793.
2022
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A recurrent chromosomal inversion suffices for driving escape from oncogene-induced senescence via subTAD reorganization..
81.
2021
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PKCλ/ι inhibition activates an ULK2-mediated interferon response to repress tumorigenesis..
81.
2021
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Structural features of nucleosomes in interphase and metaphase chromosomes..
81.
2021
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Lysine acetylation restricts mutant IDH2 activity to optimize transformation in AML cells..
81.
2021
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Targeting histone acetylation dynamics and oncogenic transcription by catalytic P300/CBP inhibition..
81.
2021
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A unified atlas of CD8 T cell dysfunctional states in cancer and infection..
81.
2021
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mTORC1 promotes cell growth via m6A-dependent mRNA degradation..
81.
2021
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H3K27ac bookmarking promotes rapid post-mitotic activation of the pluripotent stem cell program without impacting 3D chromatin reorganization..
81.
2021
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Regulation of PTEN translation by PI3K signaling maintains pathway homeostasis..
81.
2021
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PKCl/i inhibition activates an ULK2-mediated interferon response to repress tumorigenesis
2021
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Unique Immune Cell Coactivators Specify Locus Control Region Function and Cell Stage..
80.
2020
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Zmat3 Is a Key Splicing Regulator in the p53 Tumor Suppression Program..
80.
2020
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Structural Basis of the Activation of Heterotrimeric Gs-Protein by Isoproterenol-Bound β1-Adrenergic Receptor..
80.
2020
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High-Resolution In Vivo Identification of miRNA Targets by Halo-Enhanced Ago2 Pull-Down..
79.
2020
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MYC Controls the Epstein-Barr Virus Lytic Switch..
78.
2020
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Altered m6A Modification of Specific Cellular Transcripts Affects Flaviviridae Infection..
77.
2019
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Transient Hysteresis in CDK4/6 Activity Underlies Passage of the Restriction Point in G1..
76.
2019
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Bicoid-Dependent Activation of the Target Gene hunchback Requires a Two-Motif Sequence Code in a Specific Basal Promoter..
75.
2019
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Identification of the m6Am Methyltransferase PCIF1 Reveals the Location and Functions of m6Am in the Transcriptome..
75.
2019
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Cyclin F Controls Cell-Cycle Transcriptional Outputs by Directing the Degradation of the Three Activator E2Fs..
74.
2019
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TAF5L and TAF6L Maintain Self-Renewal of Embryonic Stem Cells via the MYC Regulatory Network..
74.
2019
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An NAD+ Phosphorylase Toxin Triggers Mycobacterium tuberculosis Cell Death..
73.
2019
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The F-Box Domain-Dependent Activity of EMI1 Regulates PARPi Sensitivity in Triple-Negative Breast Cancers..
73.
2018
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ZFX Mediates Non-canonical Oncogenic Functions of the Androgen Receptor Splice Variant 7 in Castrate-Resistant Prostate Cancer..
72.
2018
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Mycobacterial Mutagenesis and Drug Resistance Are Controlled by Phosphorylation- and Cardiolipin-Mediated Inhibition of the RecA Coprotease..
72.
2018
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Binding of TMPRSS2-ERG to BAF Chromatin Remodeling Complexes Mediates Prostate Oncogenesis..
71.
2018
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MRI Is a DNA Damage Response Adaptor during Classical Non-homologous End Joining..
71.
2018
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MLL4 Is Required to Maintain Broad H3K4me3 Peaks and Super-Enhancers at Tumor Suppressor Genes..
70.
2018
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mTORC1 Promotes Metabolic Reprogramming by the Suppression of GSK3-Dependent Foxk1 Phosphorylation..
70.
2018
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Phosphatidylinositol-5-Phosphate 4-Kinases Regulate Cellular Lipid Metabolism By Facilitating Autophagy..
70.
2018
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The Dietary Supplement Chondroitin-4-Sulfate Exhibits Oncogene-Specific Pro-tumor Effects on BRAF V600E Melanoma Cells..
69.
2018
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The Histone Chaperones ASF1 and CAF-1 Promote MMS22L-TONSL-Mediated Rad51 Loading onto ssDNA during Homologous Recombination in Human Cells..
69.
2018
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The Augmented R-Loop Is a Unifying Mechanism for Myelodysplastic Syndromes Induced by High-Risk Splicing Factor Mutations..
69.
2018
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Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition..
67.
2017
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Argonaute CLIP Defines a Deregulated miR-122-Bound Transcriptome that Correlates with Patient Survival in Human Liver Cancer..
67.
2017
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Heterogeneous Ribosomes Preferentially Translate Distinct Subpools of mRNAs Genome-wide..
67.
2017
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Celastrol-Induced Nur77 Interaction with TRAF2 Alleviates Inflammation by Promoting Mitochondrial Ubiquitination and Autophagy..
66.
2017
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PARK2 Depletion Connects Energy and Oxidative Stress to PI3K/Akt Activation via PTEN S-Nitrosylation..
65.
2017
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The Histone Modification Domain of Paf1 Complex Subunit Rtf1 Directly Stimulates H2B Ubiquitylation through an Interaction with Rad6..
64.
2016
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Chromatin Kinases Act on Transcription Factors and Histone Tails in Regulation of Inducible Transcription..
64.
2016
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FANCD2 Facilitates Replication through Common Fragile Sites..
64.
2016
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Tail and Kinase Modules Differently Regulate Core Mediator Recruitment and Function In Vivo..
64.
2016
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VCP/p97 Extracts Sterically Trapped Ku70/80 Rings from DNA in Double-Strand Break Repair..
64.
2016
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OCT4 Acts as an Integrator of Pluripotency and Signal-Induced Differentiation..
63.
2016
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A Highly Sensitive and Robust Method for Genome-wide 5hmC Profiling of Rare Cell Populations..
63.
2016
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An Autoinhibited Dimeric Form of BAX Regulates the BAX Activation Pathway..
63.
2016
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The Pioneer Transcription Factor FoxA Maintains an Accessible Nucleosome Configuration at Enhancers for Tissue-Specific Gene Activation..
62.
2016
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TRIM21 Ubiquitylates SQSTM1/p62 and Suppresses Protein Sequestration to Regulate Redox Homeostasis..
61.
2016
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A Multiplexed System for Quantitative Comparisons of Chromatin Landscapes..
61.
2015
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Functional Dynamics within the Human Ribosome Regulate the Rate of Active Protein Synthesis..
60.
2015
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Endogenous Formaldehyde Is a Hematopoietic Stem Cell Genotoxin and Metabolic Carcinogen..
60.
2015
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An Interactive Database for the Assessment of Histone Antibody Specificity..
59.
2015
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ERK2 Mediates Metabolic Stress Response to Regulate Cell Fate..
59.
2015
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Metabolic Rewiring by Oncogenic BRAF V600E Links Ketogenesis Pathway to BRAF-MEK1 Signaling..
59.
2015
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Engineering of a Histone-Recognition Domain in Dnmt3a Alters the Epigenetic Landscape and Phenotypic Features of Mouse ESCs..
59.
2015
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Distinct tRNA Accommodation Intermediates Observed on the Ribosome with the Antibiotics Hygromycin A and A201A..
58.
2015
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A Protein Kinase C Phosphorylation Motif in GLUT1 Affects Glucose Transport and is Mutated in GLUT1 Deficiency Syndrome..
58.
2015
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ATP-dependent effector-like functions of RIG-I-like receptors..
58.
2015
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Ubiquitin-dependent lysosomal membrane protein sorting and degradation..
57.
2015
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Asparagine plays a critical role in regulating cellular adaptation to glutamine depletion..
56.
2014
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O-GlcNAcylation regulates cancer metabolism and survival stress signaling via regulation of the HIF-1 pathway..
54.
2014
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Distinct and combinatorial functions of Jmjd2b/Kdm4b and Jmjd2c/Kdm4c in mouse embryonic stem cell identity..
53.
2013
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The DNA replication program is altered at the FMR1 locus in fragile X embryonic stem cells..
53.
2013
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Autoinhibition and Polo-dependent multisite phosphorylation restrict activity of the histone H3 kinase Haspin to mitosis..
52.
2013
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Dosage of Dyrk1a shifts cells within a p21-cyclin D1 signaling map to control the decision to enter the cell cycle..
52.
2013
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Structural architecture of the CARMA1/Bcl10/MALT1 signalosome: nucleation-induced filamentous assembly..
51.
2013
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K63 polyubiquitination and activation of mTOR by the p62-TRAF6 complex in nutrient-activated cells..
51.
2013
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Kinetic competition between elongation rate and binding of NELF controls promoter-proximal pausing..
50.
2013
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Akt-mediated phosphorylation of argonaute 2 downregulates cleavage and upregulates translational repression of MicroRNA targets..
50.
2013
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AMPK-dependent degradation of TXNIP upon energy stress leads to enhanced glucose uptake via GLUT1..
49.
2013
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PGC-1 coactivators regulate MITF and the tanning response..
49.
2012
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Metabolic stress controls mTORC1 lysosomal localization and dimerization by regulating the TTT-RUVBL1/2 complex..
49.
2012
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Transcriptome-wide miR-155 binding map reveals widespread noncanonical microRNA targeting..
48.
2012
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Cooperative activation of PI3K by Ras and Rho family small GTPases..
47.
2012
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A two-dimensional ERK-AKT signaling code for an NGF-triggered cell-fate decision..
45.
2011
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Chemical genetic screen for AMPKα2 substrates uncovers a network of proteins involved in mitosis..
44.
2011
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Aurora-B mediated ATM serine 1403 phosphorylation is required for mitotic ATM activation and the spindle checkpoint..
44.
2011
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Structure and dynamics of the mammalian ribosomal pretranslocation complex..
44.
2011
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p62 is a key regulator of nutrient sensing in the mTORC1 pathway..
44.
2011
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Directional DNA methylation changes and complex intermediate states accompany lineage specificity in the adult hematopoietic compartment..
44.
2011
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Deciphering the RNA polymerase II CTD code in fission yeast..
43.
2011
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A SIRT1-LSD1 corepressor complex regulates Notch target gene expression and development..
42.
2011
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ERK-MAPK drives lamellipodia protrusion by activating the WAVE2 regulatory complex..
41.
2011
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A comprehensive genomic binding map of gene and chromatin regulatory proteins in Saccharomyces..
41.
2011
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Elevated histone expression promotes life span extension..
39.
2010
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Sin1-mTORC2 suppresses rag and il7r gene expression through Akt2 in B cells..
39.
2010
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Multiple interactions recruit MLL1 and MLL1 fusion proteins to the HOXA9 locus in leukemogenesis..
38.
2010
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Glucose addiction of TSC null cells is caused by failed mTORC1-dependent balancing of metabolic demand with supply..
38.
2010
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ERK2 but not ERK1 induces epithelial-to-mesenchymal transformation via DEF motif-dependent signaling events..
38.
2010
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Revealing global regulatory perturbations across human cancers..
36.
2009
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Brh2 promotes a template-switching reaction enabling recombinational bypass of lesions during DNA synthesis..
36.
2009
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Stepwise activation of BAX and BAK by tBID, BIM, and PUMA initiates mitochondrial apoptosis..
36.
2009
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Interaction of transcriptional regulators with specific nucleosomes across the Saccharomyces genome..
35.
2009
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A genome-wide siRNA screen reveals diverse cellular processes and pathways that mediate genome stability..
35.
2009
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CUL4A abrogation augments DNA damage response and protection against skin carcinogenesis..
34.
2009
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TFIIH and P-TEFb coordinate transcription with capping enzyme recruitment at specific genes in fission yeast..
33.
2009
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Second-end capture in DNA double-strand break repair promoted by Brh2 protein of Ustilago maydis..
33.
2009
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Structural basis for recognition of diubiquitins by NEMO..
33.
2009
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An unusual allosteric mobility of the C-terminal helix of a high-affinity alphaL integrin I domain variant bound to ICAM-5..
31.
2008
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RNA repair: an antidote to cytotoxic eukaryal RNA damage..
31.
2008
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A conformational rearrangement in the spliceosome sets the stage for Prp22-dependent mRNA release..
30.
2008
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The mechanism of a neurotransmitter:sodium symporter--inward release of Na+ and substrate is triggered by substrate in a second binding site..
30.
2008
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Regulation of cell signaling dynamics by the protein kinase-scaffold Ste5..
30.
2008
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Comprehensive identification of PIP3-regulated PH domains from C. elegans to H. sapiens by model prediction and live imaging..
30.
2008
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Ran-binding protein 3 phosphorylation links the Ras and PI3-kinase pathways to nucleocytoplasmic transport..
29.
2008
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Structure of a BCOR corepressor peptide in complex with the BCL6 BTB domain dimer..
29.
2008
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A hypoxia-controlled cap-dependent to cap-independent translation switch in breast cancer..
28.
2007
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A universal framework for regulatory element discovery across all genomes and data types..
28.
2007
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Functional interdependence at the chromatin level between the MKK6/p38 and IGF1/PI3K/AKT pathways during muscle differentiation..
28.
2007
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Identification of two distinct hybrid state intermediates on the ribosome..
25.
2007
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An acetylation site in the middle domain of Hsp90 regulates chaperone function..
25.
2007
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A stapled BID BH3 helix directly binds and activates BAX..
24.
2006
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A kinase-independent function of c-Abl in promoting proteolytic destruction of damaged DNA binding proteins..
22.
2006
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c-Myc phosphorylation is required for cellular response to oxidative stress..
21.
2006
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Transcriptional activators are dispensable for transcription in the absence of Spt6-mediated chromatin reassembly of promoter regions..
21.
2006
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Detection of high-affinity and sliding clamp modes for MSH2-MSH6 by single-molecule unzipping force analysis..
20.
2005
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MDM2 promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma protein..
20.
2005
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Crystal structure of IIGP1: a paradigm for interferon-inducible p47 resistance GTPases..
15.
2004
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Molecular mechanism of transcription inhibition by peptide antibiotic Microcin J25..
14.
2004
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Chromatin disassembly mediated by the histone chaperone Asf1 is essential for transcriptional activation of the yeast PHO5 and PHO8 genes..
14.
2004
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Genome-wide analysis of membrane targeting by S. cerevisiae pleckstrin homology domains..
13.
2004
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A genome-wide housekeeping role for TFIID and a highly regulated stress-related role for SAGA in Saccharomyces cerevisiae..
13.
2004
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A function of yeast mRNA cap methyltransferase, Abd1, in transcription by RNA polymerase II..
13.
2004
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Mechanism of SMRT corepressor recruitment by the BCL6 BTB domain..
12.
2003
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Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2..
12.
2003
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The BRCA2-interacting protein DSS1 is vital for DNA repair, recombination, and genome stability in Ustilago maydis..
12.
2003
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In vivo roles of Rad52, Rad54, and Rad55 proteins in Rad51-mediated recombination..
12.
2003
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Interplay of TBP inhibitors in global transcriptional control..
10.
2002
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BRCA2 homolog required for proficiency in DNA repair, recombination, and genome stability in Ustilago maydis..
10.
2002
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Tat stimulates cotranscriptional capping of HIV mRNA..
10.
2002
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Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway..
10.
2002
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Targeted disruption of the zetaPKC gene results in the impairment of the NF-kappaB pathway..
8.
2001
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Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis..
8.
2001
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BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis..
8.
2001
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Analysis of telomerase processivity: mechanistic similarity to HIV-1 reverse transcriptase and role in telomere maintenance..
7.
2001
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Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance..
6.
2000
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Class C Vps protein complex regulates vacuolar SNARE pairing and is required for vesicle docking/fusion..
6.
2000
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Harnessing the ubiquitination machinery to target the degradation of specific cellular proteins..
6.
2000
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The hPLIC proteins may provide a link between the ubiquitination machinery and the proteasome..
6.
2000
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Aven, a novel inhibitor of caspase activation, binds Bcl-xL and Apaf-1..
6.
2000
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Acquisition of oncogenic potential by RAR chimeras in acute promyelocytic leukemia through formation of homodimers..
5.
2000
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A novel mycolic acid cyclopropane synthetase is required for cording, persistence, and virulence of Mycobacterium tuberculosis..
5.
2000
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Regulation of Wnt signaling by Sox proteins: XSox17 alpha/beta and XSox3 physically interact with beta-catenin..
4.
1999
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TFIIA regulates TBP and TFIID dimers..
4.
1999
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A role for TBP dimerization in preventing unregulated gene expression..
3.
1999
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Phosphatidylinositol 3-phosphate recognition by the FYVE domain..
3.
1999
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Arrangement of subunits in 20 S particles consisting of NSF, SNAPs, and SNARE complexes..
2.
1998
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Ubiquitination and degradation of the substrate recognition subunits of SCF ubiquitin-protein ligases..
2.
1998
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Ku70: a candidate tumor suppressor gene for murine T cell lymphoma..
2.
1998
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Phosphatidylinositol(3)-phosphate signaling mediated by specific binding to RING FYVE domains..
2.
1998
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Alkyl hydroperoxide reductase subunit C (AhpC) protects bacterial and human cells against reactive nitrogen intermediates..
1.
1998
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Terminal differentiation of human breast cancer through PPAR gamma..
1.
1998
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A field guide to endogenous retrovirus regulatory networks..
82.
2022
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Thinking Outside the Cell: Replicating Replication In Vitro..
65.
2017
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Resolving resolvases: the final act?.
32.
2008
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Circling back to PTEN: Fumarate inhibits canonical tumor suppressor.
2022
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HATs off to PIC assembly.
2006
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Editorial Note to: Glucose Addiction of TSC Null Cells Is Caused by Failed mTORC1-Dependent Balancing of Metabolic Demand with Supply..
81.
2021
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Greater Than the Sum of Parts: Complexity of the Dynamic Epigenome.
2016
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Drugging Chromatin in Cancer: Recent Advances and Novel Approaches.
2015
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Preparing the first responders: building the inflammatory transcriptome from the ground up.
2014
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DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase.
2007
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Cell signaling and function organized by PB1 domain interactions.
2006
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RNAi targeting an animal virus: news from the front.
2002
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Molecular impact of mutations in RNA splicing factors in cancer.
2024
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Hidden codes in mRNA: Control of gene expression by m6A.
2022
Identity
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