Hijacking the powerhouse: Mitochondrial transfer and mitophagy as emerging mechanisms of immune evasion. Academic Article uri icon

Overview

abstract

  • Cancer cells subvert the immune system by reprogramming their metabolism. In a recent study in Nature, Ikeda et al.1 show how cancer cells can directly transfer mitophagy-resistant mitochondria to tumor-infiltrating lymphocytes, promoting their homoplasmic replacement and undermining cancer immunity.

publication date

  • April 3, 2025

Research

keywords

  • Immune Evasion
  • Lymphocytes, Tumor-Infiltrating
  • Mitochondria
  • Mitophagy
  • Neoplasms
  • Tumor Escape

Identity

Scopus Document Identifier

  • 105001108433

Digital Object Identifier (DOI)

  • 10.1016/j.molcel.2025.02.026

PubMed ID

  • 40185077

Additional Document Info

volume

  • 85

issue

  • 7