Tolerance induction by allogeneic hematopoietic stem cells.
Overview
abstract
In this issue of Cell Stem Cell, Zheng et al. (2011) report that HSCs expressing PD-L1 display enhanced engraftment in irradiated allogeneic recipients. Independently in Nature, Fujisaki et al. (2011) observe allogeneic HSCs persisting in proximity to regulatory T cells in nonirradiated recipients, further connecting HSCs and immune tolerance.
