Animal models for microbicide studies. Review uri icon

Overview

abstract

  • There have been encouraging recent successes in the development of safe and effective topical microbicides to prevent vaginal or rectal HIV-1 transmission, based on the use of anti-retroviral drugs. However, much work remains to be accomplished before a microbicide becomes a standard element of prevention science strategies. Animal models should continue to play an important role in pre-clinical testing, with emphasis on safety, pharmacokinetic and efficacy testing.

publication date

  • January 1, 2012

Research

keywords

  • Anti-Infective Agents, Local
  • Anti-Retroviral Agents
  • Disease Models, Animal
  • HIV Infections
  • HIV-1

Identity

PubMed Central ID

  • PMC3712901

Scopus Document Identifier

  • 84863393491

PubMed ID

  • 22264049

Additional Document Info

volume

  • 10

issue

  • 1