The link between angiotensin II-mediated anxiety and mood disorders with NADPH oxidase-induced oxidative stress. Academic Article uri icon

Overview

abstract

  • The renin-angiotensin system (RAS) and its active peptide angiotensin II (AngII) have major involvements not only in hypertension but also in mood and anxiety disorders. Substantial evidence supports the notion that AngII acts as a neuromodulator in the brain. In this review, we provide an overview of the link between the RAS and anxiety or mood disorders, and focus on recent advances in the understanding of AngII-linked, NADPH oxidase-derived oxidative stress in the central nervous system, which may underlie pathogenesis of mood and anxiety disorders.

publication date

  • February 15, 2012

Identity

PubMed Central ID

  • PMC3312460

PubMed ID

  • 22461954

Additional Document Info

volume

  • 4

issue

  • 1