Wang, Gang

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selected publications

A cell-autonomous role for border-associated macrophages in ApoE4 neurovascular dysfunction and susceptibility to white matter injury. Nature neuroscience. 2024 Academic Article GET IT
Tumor necrosis factor alpha induces NOX2-dependent reactive oxygen species production in hypothalamic paraventricular nucleus neurons following angiotensin II infusion. Neurochemistry international. 2024 Academic Article GET IT
Meningeal interleukin-17-producing T cells mediate cognitive impairment in a mouse model of salt-sensitive hypertension. Nature neuroscience. 2023 Academic Article GET IT
Estrogen receptor beta activity contributes to both tumor necrosis factor alpha expression in the hypothalamic paraventricular nucleus and the resistance to hypertension following angiotensin II in female mice. Neurochemistry international. 2022 Academic Article GET IT
Angiotensin II infusion results in both hypertension and increased AMPA GluA1 signaling in hypothalamic paraventricular nucleus of male but not female mice. Neuroscience. 2022 Academic Article GET IT
Adolescent administration of Δ⁹-THC decreases the expression and function of muscarinic-1 receptors in prelimbic prefrontal cortical neurons of adult male mice. IBRO neuroscience reports. 2021 Academic Article GET IT
Estrogen Receptor β Contributes to Both Hypertension and Hypothalamic Plasticity in a Mouse Model of Peri-Menopause. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2021 Academic Article GET IT
Times cited: 19
Tumor Necrosis Factor α Receptor Type 1 Activation in the Hypothalamic Paraventricular Nucleus Contributes to Glutamate Signaling and Angiotensin II-Dependent Hypertension. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2020 Academic Article GET IT
Times cited: 21
tPA Deficiency Underlies Neurovascular Coupling Dysfunction by Amyloid-β. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2020 Academic Article GET IT
Times cited: 34
Tau induces PSD95-neuronal NOS uncoupling and neurovascular dysfunction independent of neurodegeneration. Nature neuroscience. 2020 Academic Article GET IT
Times cited: 70
Amyloid-Beta Modulates Low-Threshold Activated Voltage-Gated L-Type Calcium Channels of Arcuate Neuropeptide Y Neurons Leading to Calcium Dysregulation and Hypothalamic Dysfunction. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2019 Academic Article GET IT
Times cited: 36
Chronic adolescent exposure to ∆9-tetrahydrocannabinol decreases NMDA current and extrasynaptic plasmalemmal density of NMDA GluN1 subunits in the prelimbic cortex of adult male mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2019 Academic Article GET IT
Times cited: 15
Apoε4 disrupts neurovascular regulation and undermines white matter integrity and cognitive function. Nature communications. 2018 Academic Article GET IT
Times cited: 106
Dietary salt promotes neurovascular and cognitive dysfunction through a gut-initiated TH17 response. Nature neuroscience. 2018 Academic Article GET IT
Times cited: 239
New generations of dihydropyridines for treatment of hypertension. Journal of geriatric cardiology : JGC. 2017 Information Resource GET IT
Times cited: 56
Redistribution of NMDA Receptors in Estrogen-Receptor-β-Containing Paraventricular Hypothalamic Neurons following Slow-Pressor Angiotensin II Hypertension in Female Mice with Accelerated Ovarian Failure. Neuroendocrinology. 2016 Academic Article GET IT
Times cited: 22
Endothelial Dysfunction and Amyloid-β-Induced Neurovascular Alterations. Cellular and molecular neurobiology. 2015 Information Resource GET IT
Times cited: 90
NMDA Receptor Plasticity in the Hypothalamic Paraventricular Nucleus Contributes to the Elevated Blood Pressure Produced by Angiotensin II. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2015 Academic Article GET IT
Times cited: 44
Female protection from slow-pressor effects of angiotensin II involves prevention of ROS production independent of NMDA receptor trafficking in hypothalamic neurons expressing angiotensin 1A receptors. Synapse (New York, N.Y.). 2015 Academic Article GET IT
Times cited: 28
The key role of transient receptor potential melastatin-2 channels in amyloid-β-induced neurovascular dysfunction. Nature communications. 2014 Academic Article GET IT
Times cited: 106
Transgenic mice overexpressing amyloid precursor protein exhibit early metabolic deficits and a pathologically low leptin state associated with hypothalamic dysfunction in arcuate neuropeptide Y neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2014 Academic Article GET IT
Times cited: 72
COX-1-derived PGE2 and PGE2 type 1 receptors are vital for angiotensin II-induced formation of reactive oxygen species and Ca(2+) influx in the subfornical organ. American journal of physiology. Heart and circulatory physiology. 2013 Academic Article GET IT
Times cited: 30
Angiotensin II slow-pressor hypertension enhances NMDA currents and NOX2-dependent superoxide production in hypothalamic paraventricular neurons. American journal of physiology. Regulatory, integrative and comparative physiology. 2013 Academic Article GET IT
Times cited: 54
Membrane trafficking of NADPH oxidase p47(phox) in paraventricular hypothalamic neurons parallels local free radical production in angiotensin II slow-pressor hypertension. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2013 Academic Article GET IT
Times cited: 38
Activation of HIF2α in kidney proximal tubule cells causes abnormal glycogen deposition but not tumorigenesis. Cancer research. 2013 Academic Article GET IT
Times cited: 38
ER stress in the brain subfornical organ mediates angiotensin-dependent hypertension. The Journal of clinical investigation. 2012 Academic Article GET IT
Times cited: 130
Distribution of angiotensin type 1a receptor-containing cells in the brains of bacterial artificial chromosome transgenic mice. Neuroscience. 2012 Academic Article GET IT
Times cited: 53
Angiotensin II type 2 receptor-coupled nitric oxide production modulates free radical availability and voltage-gated Ca2+ currents in NTS neurons. American journal of physiology. Regulatory, integrative and comparative physiology. 2012 Academic Article GET IT
Times cited: 24
Angiotensin II-dependent hypertension requires cyclooxygenase 1-derived prostaglandin E2 and EP1 receptor signaling in the subfornical organ of the brain. Hypertension (Dallas, Tex. : 1979). 2012 Academic Article GET IT
Times cited: 49
The link between angiotensin II-mediated anxiety and mood disorders with NADPH oxidase-induced oxidative stress. International journal of physiology, pathophysiology and pharmacology. 2012 Academic Article GET IT
Prohibitin reduces mitochondrial free radical production and protects brain cells from different injury modalities. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2012 Academic Article GET IT
Times cited: 77
Generation of a mouse model of Von Hippel-Lindau kidney disease leading to renal cancers by expression of a constitutively active mutant of HIF1α. Cancer research. 2011 Academic Article GET IT
Times cited: 81
Scavenger receptor CD36 is essential for the cerebrovascular oxidative stress and neurovascular dysfunction induced by amyloid-beta. Proceedings of the National Academy of Sciences of the United States of America. 2011 Academic Article GET IT
Times cited: 133
Chronic intermittent hypoxia induces NMDA receptor-dependent plasticity and suppresses nitric oxide signaling in the mouse hypothalamic paraventricular nucleus. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2010 Academic Article GET IT
Times cited: 61
Distribution of estrogen receptor β containing cells in the brains of bacterial artificial chromosome transgenic mice. Brain research. 2010 Academic Article GET IT
Times cited: 60
The effects of DNA methyltransferase inhibitors and histone deacetylase inhibitors on digit regeneration in mice. Regenerative medicine. 2010 Academic Article GET IT
Times cited: 22
Epimorphic regeneration approach to tissue replacement in adult mammals. Proceedings of the National Academy of Sciences of the United States of America. 2009 Academic Article GET IT
Times cited: 134
NMDA receptor activation increases free radical production through nitric oxide and NOX2. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2009 Academic Article GET IT
Times cited: 211
The potassium ion channel opener NS1619 inhibits proliferation and induces apoptosis in A2780 ovarian cancer cells. Biochemical and biophysical research communications. 2008 Academic Article GET IT
Times cited: 37
Sex differences in angiotensin signaling in bulbospinal neurons in the rat rostral ventrolateral medulla. American journal of physiology. Regulatory, integrative and comparative physiology. 2008 Academic Article GET IT
Times cited: 30
Key role of tissue plasminogen activator in neurovascular coupling. Proceedings of the National Academy of Sciences of the United States of America. 2008 Academic Article GET IT
Times cited: 82
Heat shock proteins and p53 play a critical role in K+ channel-mediated tumor cell proliferation and apoptosis. Apoptosis : an international journal on programmed cell death. 2007 Academic Article GET IT
Times cited: 37
Mechanisms and optimization of in vivo delivery of lipophilic siRNAs. Nature biotechnology. 2007 Academic Article GET IT
Times cited: 688
Subcellular localization of nicotinamide adenine dinucleotide phosphate oxidase subunits in neurons and astroglia of the rat medial nucleus tractus solitarius: relationship with tyrosine hydroxylase immunoreactive neurons. Neuroscience. 2006 Academic Article GET IT
Times cited: 27
Nox2, Ca2+, and protein kinase C play a role in angiotensin II-induced free radical production in nucleus tractus solitarius. Hypertension (Dallas, Tex. : 1979). 2006 Academic Article GET IT
Times cited: 92
Evidence that estrogen directly and indirectly modulates C1 adrenergic bulbospinal neurons in the rostral ventrolateral medulla. Brain research. 2006 Academic Article GET IT
Times cited: 46
Prostaglandin E2 EP1 receptors: downstream effectors of COX-2 neurotoxicity. Nature medicine. 2006 Academic Article GET IT
Times cited: 313
DNA amplification method tolerant to sample degradation. Genome research. 2004 Academic Article GET IT
Times cited: 78
Distinct rat neurohypophysial nerve terminal populations identified by size, electrophysiological properties and neuropeptide content. Brain research. 2004 Academic Article GET IT
Times cited: 7
Exogenous NADPH increases cerebral blood flow through NADPH oxidase-dependent and -independent mechanisms. Arteriosclerosis, thrombosis, and vascular biology. 2004 Academic Article GET IT
Times cited: 50
NADPH oxidase contributes to angiotensin II signaling in the nucleus tractus solitarius. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2004 Academic Article GET IT
Times cited: 161
Angiotensin II attenuates functional hyperemia in the mouse somatosensory cortex. American journal of physiology. Heart and circulatory physiology. 2003 Academic Article GET IT
Times cited: 73
Isoflurane and propofol inhibit voltage-gated sodium channels in isolated rat neurohypophysial nerve terminals. Molecular pharmacology. 2003 Academic Article GET IT
Times cited: 77
Adenosine inhibition via A(1) receptor of N-type Ca(2+) current and peptide release from isolated neurohypophysial terminals of the rat. The Journal of physiology. 2002 Academic Article GET IT
Times cited: 28
Evidence for endogenous agmatine in hypothalamo-neurohypophysial tract and its modulation on vasopressin release and Ca2+ channels. Brain research. 2002 Academic Article GET IT
Times cited: 24
Localization of agmatine in vasopressin and oxytocin neurons of the rat hypothalamic paraventricular and supraoptic nuclei. Experimental neurology. 2001 Academic Article GET IT
Times cited: 38
Specific actions of cyanide on membrane potential and voltage-gated ion currents in rostral ventrolateral medulla neurons in rat brainstem slices. Neuroscience letters. 2001 Academic Article GET IT
Times cited: 21
Excitatory versus inhibitory modulation by ATP of neurohypophysial terminal activity in the rat. Experimental physiology. 2000 Information Resource GET IT
Times cited: 23
An R-type Ca(2+) current in neurohypophysial terminals preferentially regulates oxytocin secretion. The Journal of neuroscience : the official journal of the Society for Neuroscience. 1999 Academic Article GET IT
Times cited: 110
Rat supraoptic magnocellular neurones show distinct large conductance, Ca2+-activated K+ channel subtypes in cell bodies versus nerve endings. The Journal of physiology. 1999 Academic Article GET IT
Times cited: 88
Selective peptide antagonist of the class E calcium channel from the venom of the tarantula Hysterocrates gigas. Biochemistry. 1998 Academic Article GET IT
Times cited: 319
Voltage dependent calcium and potassium currents in Y-1 adrenocortical cells are unresponsive to ACTH. Endocrine research. 1997 Academic Article GET IT
Times cited: 5
Role of Q-type Ca2+ channels in vasopressin secretion from neurohypophysial terminals of the rat. The Journal of physiology. 1997 Academic Article GET IT
Times cited: 73
Retrovirus-mediated transfer of the human O6-methylguanine-DNA methyltransferase gene into a murine hematopoietic stem cell line and resistance to the toxic effects of certain alkylating agents. Biochemical pharmacology. 1996 Academic Article GET IT
Times cited: 33
Effects of funnel web spider toxin on Ca2+ currents in neurohypophysial terminals. Brain research. 1994 Academic Article GET IT
Times cited: 19
Ethanol directly modulates gating of a dihydropyridine-sensitive Ca2+ channel in neurohypophysial terminals. The Journal of neuroscience : the official journal of the Society for Neuroscience. 1994 Academic Article GET IT
Times cited: 80
Effects of toxins on Ca2+ currents and peptide release from nerve terminals. Annals of the New York Academy of Sciences. 1994 Academic Article GET IT
Times cited: 15
Comparison of effects of tetrandrine on ionic channels of isolated rat neurohypophysial terminals and Y1 mouse adrenocortical tumor cells. Zhongguo yao li xue bao = Acta pharmacologica Sinica. 1993 Academic Article GET IT
Times cited: 13
A novel large-conductance Ca(2+)-activated potassium channel and current in nerve terminals of the rat neurohypophysis. The Journal of physiology. 1992 Academic Article GET IT
Times cited: 49
Tetrandrine blocks a slow, large-conductance, Ca(2+)-activated potassium channel besides inhibiting a non-inactivating Ca2+ current in isolated nerve terminals of the rat neurohypophysis. Pflugers Archiv : European journal of physiology. 1992 Academic Article GET IT
Times cited: 48
Sodium channel comodification with full activator reveals veratridine reaction dynamics. Molecular pharmacology. 1990 Academic Article GET IT
Times cited: 21
Interaction between DPI 201-106 enantiomers at the cardiac sodium channel. Molecular pharmacology. 1990 Academic Article GET IT
Times cited: 30

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Research

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Funding awarded

Alzheimer Pathology and Neurovascular Dysfunction awarded by National Institute of Neurological Disorders & Stroke Co-Investigator 2023 - 2027
ApoE4, neurovascular injury and cognitive impairment awarded by National Institute of Neurological Disorders & Stroke Co-Investigator 2022 - 2027
Contribution of G Protein Coupled Estrogen Receptor to Changes in Hypothalamic Plasticity and Hypertension Susceptibility in Mice with Accelerated Ovarian Failure awarded by National Heart, Lung, & Blood Institute Co-Investigator 2023 - 2026
Dietary sodium, neurovascular dysfunction and cerebrovascular risk awarded by National Institute of Neurological Disorders & Stroke Co-Investigator 2021 - 2026
Tau-induced postsynaptic dysfunction in tauopathy models awarded by Cure Alzheimer’s Fund Co-Investigator 2023 - 2025
missing activity Co-Investigator 2021 - 2025
Role of CaMKII-alpha ubiquitination in ischemic stroke awarded by National Institute of Neurological Disorders & Stroke Co-Investigator 2018 - 2024

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Background

education and training

B.M., Tongji Medical College of Huazhong University of Science and Technology (China) 83
Ph.D., Tongji Medical College of Huazhong University of Science and Technology (China) 1989

VIVO Weill Cornell Medical College

Gang Wang Associate Professor of Research in Neuroscience

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

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