ski can cause selective growth of skeletal muscle in transgenic mice. Academic Article uri icon

Overview

abstract

  • We have created several lines of mice that contain a truncated chicken c-ski cDNA linked to an MSV LTR promoter. Adult mice from three independent lines show large increases in skeletal muscle. All three lines of mice express high levels of c-ski mRNA and protein in skeletal muscle. All other tissues examined show little or no expression of the c-ski transgene. The muscles of one of the three lines were examined in more detail. Type II fast fibers undergo selective hypertrophy in affected muscles of this line.

publication date

  • September 1, 1990

Research

keywords

  • DNA-Binding Proteins
  • Muscle Development
  • Proto-Oncogene Proteins

Identity

Scopus Document Identifier

  • 0025182773

PubMed ID

  • 2253874

Additional Document Info

volume

  • 4

issue

  • 9