Memory CD4(+) T lymphocytes in the gastrointestinal tract are a major source of cell-associated simian immunodeficiency virus in chronic nonpathogenic infection of African green monkeys. Academic Article uri icon

Overview

abstract

  • Simian immunodeficiency virus (SIV) infection of natural hosts is characterized by nonpathogenic chronic viremia, maintenance of gastrointestinal epithelial barrier integrity, and low numbers of target cells. Assessment of cell-associated virus load in T cell subsets in multiple anatomic compartments of chronically SIV-infected sabeus African green monkeys (AGMs) revealed that gastrointestinal memory CD4(+) T lymphocytes are a major source of cell-associated virus and a significant contributor to SIV viremia in AGMs.

publication date

  • August 15, 2012

Research

keywords

  • CD4-Positive T-Lymphocytes
  • Gastrointestinal Tract
  • Immunologic Memory
  • Simian Acquired Immunodeficiency Syndrome
  • Simian Immunodeficiency Virus

Identity

PubMed Central ID

  • PMC3457182

Scopus Document Identifier

  • 84869078435

PubMed ID

  • 22896600

Additional Document Info

volume

  • 86

issue

  • 20