(89)Zr-labeled paramagnetic octreotide-liposomes for PET-MR imaging of cancer. Academic Article uri icon

Overview

abstract

  • PURPOSE: Dual-modality PET/MR platforms add a new dimension to patient diagnosis with high resolution, functional, and anatomical imaging. The full potential of this emerging hybrid modality could be realized by using a corresponding dual-modality probe. Here, we report pegylated liposome (LP) formulations, housing a MR T(1) contrast agent (Gd) and the positron-emitting (89)Zr (half-life: 3.27 days), for simultaneous PET and MR tumor imaging capabilities. METHODS: (89)Zr oxophilicity was unexpectedly found advantageous for direct radiolabeling of preformed paramagnetic LPs. LPs were conjugated with octreotide to selectively target neuroendocrine tumors via human somatostatin receptor subtype 2 (SSTr2). (89)Zr-Gd-LPs and octreotide-conjugated homolog were physically, chemically and biologically characterized. RESULTS: (89)Zr-LPs showed reasonable stability over serum proteins and chelator challenges for proof-of-concept in vitro and in vivo investigations. Nuclear and paramagnetic tracking quantified superior SSTr2-recognition of octreotide-LP compared to controls. CONCLUSIONS: This study demonstrated SSTr2-targeting specificity along with direct chelator-free (89)Zr-labeling of LPs and dual PET/MR imaging properties.

publication date

  • December 7, 2012

Research

keywords

  • Contrast Media
  • Gadolinium
  • Liposomes
  • Neuroendocrine Tumors
  • Octreotide
  • Zirconium

Identity

PubMed Central ID

  • PMC3578092

Scopus Document Identifier

  • 84878893321

Digital Object Identifier (DOI)

  • 10.1007/s11095-012-0929-8

PubMed ID

  • 23224977

Additional Document Info

volume

  • 30

issue

  • 3