Designing a type I interferon signaling phagosome.
Overview
abstract
Circulating immune complexes trigger type I interferons exacerbating disease in systemic lupus erythematosus. In this issue of Immunity, Henault et al. (2012) show that Fcγ-receptor, Toll-like receptor 9, and LC3 conspire to mold phagosomes into type I interferon signaling platforms.
