Kinase inhibitors: a new tool for the treatment of rheumatoid arthritis. Review uri icon

Overview

abstract

  • Despite aggressive immunosuppression with biologics and traditional DMARDs, achieving disease remission remains an unmet goal for most rheumatoid arthritis (RA) patients. In this context, there is a demand for novel treatment strategies, with kinase inhibitors expected to enrich the existing therapeutic armamentarium. In RA some kinases participate in the generation of pathogenic signaling cascades. Pharmacologic inhibition of kinases that mediate pathogenic signal transduction heralds a new era for RA therapeutics. Oral inhibitors of JAKs, Syk, PI3Ks, MAPKs and Btk are under development or in clinical trials in patients with RA. In this review, we discuss the scientific rationale for the use of kinase inhibitors in RA and summarize the experience from clinical trials.

publication date

  • April 17, 2013

Research

keywords

  • Arthritis, Rheumatoid
  • Protein Kinase Inhibitors

Identity

Scopus Document Identifier

  • 84877355643

Digital Object Identifier (DOI)

  • 10.1016/j.clim.2013.04.007

PubMed ID

  • 23651870

Additional Document Info

volume

  • 148

issue

  • 1