Heritable one-hit events defining cancer prevention? Academic Article uri icon

Overview

abstract

  • Over 100 years ago (1902-1914) Theodor Boveri suggested a role for mutations in cancer. Boveri's ideas were derived from the then "just-emerging" chromosome theory of inheritance. While demonstrating chromosomal aberrations as a cause of genetic imbalance, Boveri suggested that possible causes of malignancy may include events such as aneuploidy that are now defined as gene mutations, asserting all the while that malignancy occurs at the cellular level. Indeed, studies to date essentially uniformly show that cancer is a genetic disease.

publication date

  • July 29, 2013

Research

keywords

  • Carcinogenesis
  • Genes, Tumor Suppressor
  • Genetic Predisposition to Disease
  • Models, Biological
  • Mutation
  • Neoplasms

Identity

PubMed Central ID

  • PMC3865044

Scopus Document Identifier

  • 84883220499

Digital Object Identifier (DOI)

  • 10.4161/cc.25690

PubMed ID

  • 23907126

Additional Document Info

volume

  • 12

issue

  • 16