Kopelovich, Levy

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selected publications

Retraction: Caloric Restriction Reverses Obesity-Induced Mammary Gland Inflammation in Mice. Cancer prevention research (Philadelphia, Pa.). 2022 Academic Article GET IT
Retraction: Dietary Polyphenols Suppress Elevated Levels of Proinflammatory Mediators and Aromatase in the Mammary Gland of Obese Mice. Cancer prevention research (Philadelphia, Pa.). 2022 Academic Article GET IT
Retraction: Obesity Is Associated With Inflammation and Elevated Aromatase Expression in the Mouse Mammary Gland. Cancer prevention research (Philadelphia, Pa.). 2022 Academic Article GET IT
Retraction: Pioglitazone, a PPARγ Agonist, Suppresses CYP19 Transcription: Evidence for Involvement of 15-Hydroxyprostaglandin Dehydrogenase and BRCA1. Cancer prevention research (Philadelphia, Pa.). 2022 Academic Article GET IT
Retraction: p53 Modulates Hsp90 ATPase Activity and Regulates Aryl Hydrocarbon Receptor Signaling. Cancer prevention research (Philadelphia, Pa.). 2022 Academic Article GET IT
Author Correction: Patched1 haploinsufficiency severely impacts intermediary metabolism in the skin of Ptch1^+/-/ODC transgenic mice. 2021 GET IT
Retraction: Increased Levels of COX-2 and Prostaglandin E2 Contribute to Elevated Aromatase Expression in Inflamed Breast Tissue of Obese Women. Cancer discovery. 2021 Academic Article GET IT
Naproxen chemoprevention promotes immune activation in Lynch syndrome colorectal mucosa. Gut. 2020 Academic Article GET IT
Times cited: 53
Withdrawal: p53 protein regulates Hsp90 ATPase activity and thereby Wnt signaling by modulating Aha1 expression. The Journal of biological chemistry. 2020 Academic Article GET IT
Patched1 haploinsufficiency severely impacts intermediary metabolism in the skin of Ptch1^+/-/ODC transgenic mice. Scientific reports. 2019 Academic Article GET IT
Times cited: 2
ETHE1 overexpression promotes SIRT1 and PGC1α mediated aerobic glycolysis, oxidative phosphorylation, mitochondrial biogenesis and colorectal cancer. Oncotarget. 2019 Academic Article GET IT
Global gene expression of histologically normal primary skin cells from BCNS subjects reveals "single-hit" effects that are influenced by rapamycin. Oncotarget. 2019 Academic Article GET IT
Times cited: 6
Erratum: Drug-Targeted Inhibition of Peroxisome Proliferator-Activated Receptor-gamma Enhances the Chemopreventive Effect of Anti-Estrogen Therapy. 2018 GET IT
Naproxen Inhibits UVB-induced Basal Cell and Squamous Cell Carcinoma Development in Ptch1^+/- /SKH-1 Hairless Mice. Photochemistry and photobiology. 2017 Academic Article GET IT
Times cited: 20
PPARs as determinants of the estrogen receptor lineage: use of synthetic lethality for the treatment of estrogen receptor-negative breast cancer. Oncotarget. 2017 Academic Article GET IT
Times cited: 1
Haploinsufficiency in tumor predisposition syndromes: altered genomic transcription in morphologically normal cells heterozygous for VHL or TSC mutation. Oncotarget. 2017 Academic Article GET IT
Times cited: 12
Targeting cancer stem cells with p53 modulators. Oncotarget. 2016 Academic Article GET IT
Times cited: 20
Simultaneous targeting of 5-LOX-COX and ODC block NNK-induced lung adenoma progression to adenocarcinoma in A/J mice. American journal of cancer research. 2016 Academic Article GET IT
Detection of Exosomal miRNAs in the Plasma of Melanoma Patients. Journal of clinical medicine. 2015 Academic Article GET IT
Times cited: 129
Targeting mTOR and p53 Signaling Inhibits Muscle Invasive Bladder Cancer In Vivo. Cancer prevention research (Philadelphia, Pa.). 2015 Academic Article GET IT
Times cited: 15
Shh and p50/Bcl3 signaling crosstalk drives pathogenesis of BCCs in Gorlin syndrome. Oncotarget. 2015 Academic Article GET IT
Times cited: 24
Early and delayed intervention with rapamycin prevents NNK-induced lung adenocarcinoma in A/J mice. Oncology reports. 2015 Academic Article GET IT
Times cited: 11
TP53 modulating agent, CP-31398 enhances antitumor effects of ODC inhibitor in mouse model of urinary bladder transitional cell carcinoma. American journal of cancer research. 2015 Academic Article GET IT
Small-Molecule NSC59984 Restores p53 Pathway Signaling and Antitumor Effects against Colorectal Cancer via p73 Activation and Degradation of Mutant p53. Cancer research. 2015 Academic Article GET IT
Times cited: 99
Sulindac reversal of 15-PGDH-mediated resistance to colon tumor chemoprevention with NSAIDs. Carcinogenesis. 2014 Academic Article GET IT
Times cited: 16
Differential roles of ERα and ERβ in normal and neoplastic development in the mouse mammary gland. PloS one. 2014 Academic Article GET IT
Times cited: 24
Chemoprevention of urothelial cell carcinoma growth and invasion by the dual COX-LOX inhibitor licofelone in UPII-SV40T transgenic mice. Cancer prevention research (Philadelphia, Pa.). 2014 Academic Article GET IT
Times cited: 22
p53 modulates Hsp90 ATPase activity and regulates aryl hydrocarbon receptor signaling. Cancer prevention research (Philadelphia, Pa.). 2014 Academic Article GET IT
Times cited: 17
Epithelial cell tumors of the hen reproductive tract. Avian diseases. 2014 Academic Article GET IT
Times cited: 5
p53 protein regulates Hsp90 ATPase activity and thereby Wnt signaling by modulating Aha1 expression. The Journal of biological chemistry. 2014 Academic Article GET IT
Times cited: 31
Isolation of circulating microRNAs from microvesicles found in human plasma. Methods in molecular biology (Clifton, N.J.). 2014 Academic Article GET IT
Times cited: 32
Polymorphisms in alcohol metabolism genes ADH1B and ALDH2, alcohol consumption and colorectal cancer. PloS one. 2013 Academic Article GET IT
Times cited: 31
Prodigiosin rescues deficient p53 signaling and antitumor effects via upregulating p73 and disrupting its interaction with mutant p53. Cancer research. 2013 Academic Article GET IT
Times cited: 78
Erb-041, an estrogen receptor-β agonist, inhibits skin photocarcinogenesis in SKH-1 hairless mice by downregulating the WNT signaling pathway. Cancer prevention research (Philadelphia, Pa.). 2013 Academic Article GET IT
Times cited: 43
Inhibiting cycloxygenase and ornithine decarboxylase by diclofenac and alpha-difluoromethylornithine blocks cutaneous SCCs by targeting Akt-ERK axis. PloS one. 2013 Academic Article GET IT
Times cited: 24
Immunodepletion plasma proteomics by tripleTOF 5600 and Orbitrap elite/LTQ-Orbitrap Velos/Q exactive mass spectrometers. Journal of proteome research. 2013 Academic Article GET IT
Times cited: 45
Chemopreventive effects of the p53-modulating agents CP-31398 and Prima-1 in tobacco carcinogen-induced lung tumorigenesis in A/J mice. Neoplasia (New York, N.Y.). 2013 Academic Article GET IT
Times cited: 20
Inhibition of proliferation and induction of autophagy by atorvastatin in PC3 prostate cancer cells correlate with downregulation of Bcl2 and upregulation of miR-182 and p21. PloS one. 2013 Academic Article GET IT
Times cited: 73
p53-stabilizing agent CP-31398 prevents growth and invasion of urothelial cancer of the bladder in transgenic UPII-SV40T mice. Neoplasia (New York, N.Y.). 2013 Academic Article GET IT
Times cited: 26
Heritable one-hit events defining cancer prevention?. Cell cycle (Georgetown, Tex.). 2013 Academic Article GET IT
Times cited: 11
Dietary polyphenols suppress elevated levels of proinflammatory mediators and aromatase in the mammary gland of obese mice. Cancer prevention research (Philadelphia, Pa.). 2013 Academic Article GET IT
Times cited: 35
Laccaic acid A is a direct, DNA-competitive inhibitor of DNA methyltransferase 1. The Journal of biological chemistry. 2013 Academic Article GET IT
Times cited: 67
PPARδ induces estrogen receptor-positive mammary neoplasia through an inflammatory and metabolic phenotype linked to mTOR activation. Cancer research. 2013 Academic Article GET IT
Times cited: 45
Unbiased metabolite profiling indicates that a diminished thymidine pool is the underlying mechanism of colon cancer chemoprevention by alpha-difluoromethylornithine. Cancer discovery. 2013 Academic Article GET IT
Times cited: 43
Rapamycin targeting mTOR and hedgehog signaling pathways blocks human rhabdomyosarcoma growth in xenograft murine model. Biochemical and biophysical research communications. 2013 Academic Article GET IT
Times cited: 35
Caloric restriction reverses obesity-induced mammary gland inflammation in mice. Cancer prevention research (Philadelphia, Pa.). 2013 Academic Article GET IT
Times cited: 48
Altered transcriptome signature of phenotypically normal skin fibroblasts heterozygous for CDKN2A in familial melanoma: relevance to early intervention. Oncotarget. 2013 Academic Article GET IT
Times cited: 16
Nitric oxide-releasing sulindac is a novel skin cancer chemopreventive agent for UVB-induced photocarcinogenesis. Toxicology and applied pharmacology. 2012 Academic Article GET IT
Times cited: 25
Vorinostat, an HDAC inhibitor attenuates epidermoid squamous cell carcinoma growth by dampening mTOR signaling pathway in a human xenograft murine model. Toxicology and applied pharmacology. 2012 Academic Article GET IT
Times cited: 45
PPARγ antagonist GW9662 induces functional estrogen receptor in mouse mammary organ culture: potential translational significance. Molecular and cellular biochemistry. 2012 Academic Article GET IT
Times cited: 8
Metabolic profiling, a noninvasive approach for the detection of experimental colorectal neoplasia. Cancer prevention research (Philadelphia, Pa.). 2012 Academic Article GET IT
Times cited: 48
Pioglitazone, a PPARγ agonist, suppresses CYP19 transcription: evidence for involvement of 15-hydroxyprostaglandin dehydrogenase and BRCA1. Cancer prevention research (Philadelphia, Pa.). 2012 Academic Article GET IT
Times cited: 24
Metformin, an antidiabetic agent reduces growth of cutaneous squamous cell carcinoma by targeting mTOR signaling pathway. Photochemistry and photobiology. 2012 Academic Article GET IT
Times cited: 64
Pharmacokinetics and tissue and tumor exposure of CP-31398, a p53-stabilizing agent, in rats. Cancer chemotherapy and pharmacology. 2012 Academic Article GET IT
Times cited: 7
Genotoxicity of the cancer chemopreventive drug candidates CP-31398, SHetA2, and phospho-ibuprofen. Mutation research. 2012 Academic Article GET IT
Times cited: 25
Effects of bacterial and presystemic nitroreductase metabolism of 2-chloro-5-nitro-N-phenylbenzamide on its mutagenicity and bioavailability. Chemico-biological interactions. 2012 Academic Article GET IT
Times cited: 8
The chemopreventive effect of mifepristone on mammary tumorigenesis is associated with an anti-invasive and anti-inflammatory gene signature. Cancer prevention research (Philadelphia, Pa.). 2012 Academic Article GET IT
Times cited: 4
Drug-targeted inhibition of peroxisome proliferator-activated receptor-gamma enhances the chemopreventive effect of anti-estrogen therapy. Oncotarget. 2012 Academic Article GET IT
Times cited: 22
Genetic polymorphisms in fatty acid metabolism genes and colorectal cancer. Mutagenesis. 2012 Academic Article GET IT
Times cited: 39
Nitric oxide donor exisulind is an effective inhibitor of murine photocarcinogenesis. Photochemistry and photobiology. 2012 Academic Article GET IT
Times cited: 13
Increased levels of COX-2 and prostaglandin E2 contribute to elevated aromatase expression in inflamed breast tissue of obese women. Cancer discovery. 2012 Academic Article GET IT
Times cited: 220
ATM mutations in patients with hereditary pancreatic cancer. Cancer discovery. 2011 Academic Article GET IT
Times cited: 444
Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways. Proceedings of the National Academy of Sciences of the United States of America. 2011 Academic Article GET IT
Times cited: 570
Stem cell antigen-1 deficiency enhances the chemopreventive effect of peroxisome proliferator-activated receptorγ activation. Cancer prevention research (Philadelphia, Pa.). 2011 Academic Article GET IT
Times cited: 9
Subchronic oral toxicity and metabolite profiling of the p53 stabilizing agent, CP-31398, in rats and dogs. Toxicology. 2011 Academic Article GET IT
Times cited: 11
Rapamycin and mTORC1 inhibition in the mouse: skin cancer prevention. Cancer prevention research (Philadelphia, Pa.). 2011 Comment GET IT
Times cited: 26
Inflammation and increased aromatase expression occur in the breast tissue of obese women with breast cancer. Cancer prevention research (Philadelphia, Pa.). 2011 Academic Article GET IT
Times cited: 407
Phospho-sulindac (OXT-328) combined with difluoromethylornithine prevents colon cancer in mice. Cancer prevention research (Philadelphia, Pa.). 2011 Academic Article GET IT
Times cited: 44
Aspirin and low-dose nitric oxide-donating aspirin increase life span in a Lynch syndrome mouse model. Cancer prevention research (Philadelphia, Pa.). 2011 Academic Article GET IT
Times cited: 40
Protein nitration and nitrosylation by NO-donating aspirin in colon cancer cells: Relevance to its mechanism of action. Experimental cell research. 2011 Academic Article GET IT
Times cited: 28
Phospho-ibuprofen (MDC-917) is a novel agent against colon cancer: efficacy, metabolism, and pharmacokinetics in mouse models. The Journal of pharmacology and experimental therapeutics. 2011 Academic Article GET IT
Times cited: 38
APC +/- alters colonic fibroblast proteome in FAP. Oncotarget. 2011 Academic Article GET IT
Times cited: 18
Obesity is associated with inflammation and elevated aromatase expression in the mouse mammary gland. Cancer prevention research (Philadelphia, Pa.). 2011 Academic Article GET IT
Times cited: 338
Altered folate availability modifies the molecular environment of the human colorectum: implications for colorectal carcinogenesis. Cancer prevention research (Philadelphia, Pa.). 2011 Academic Article GET IT
Times cited: 45
A molecular signature of normal breast epithelial and stromal cells from Li-Fraumeni syndrome mutation carriers. Oncotarget. 2010 Academic Article GET IT
Times cited: 31
Genetic variation in 3-hydroxy-3-methylglutaryl CoA reductase modifies the chemopreventive activity of statins for colorectal cancer. Cancer prevention research (Philadelphia, Pa.). 2010 Academic Article GET IT
Times cited: 65
Sulindac effects on inflammation and tumorigenesis in the intestine of mice with Apc and Mlh1 mutations. Carcinogenesis. 2009 Academic Article GET IT
Times cited: 9
Dietary calcium and cholecalciferol modulate cyclin D1 expression, apoptosis, and tumorigenesis in intestine of adenomatous polyposis coli1638N/+ mice. The Journal of nutrition. 2008 Academic Article GET IT
Times cited: 41
The inhibitory effect of (-)-epigallocatechin gallate on activation of the epidermal growth factor receptor is associated with altered lipid order in HT29 colon cancer cells. Cancer research. 2007 Academic Article GET IT
Times cited: 169
Tobacco smoke stimulates the transcription of amphiregulin in human oral epithelial cells: evidence of a cyclic AMP-responsive element binding protein-dependent mechanism. Cancer research. 2005 Academic Article GET IT
Times cited: 44
Levels of cyclooxygenase-2 are increased in the oral mucosa of smokers: evidence for the role of epidermal growth factor receptor and its ligands. Cancer research. 2005 Academic Article GET IT
Times cited: 116
Tobacco smoke induces CYP1B1 in the aerodigestive tract. Carcinogenesis. 2004 Academic Article GET IT
Times cited: 69
Benzo[a]pyrene phenols are more potent inducers of CYP1A1, CYP1B1 and COX-2 than benzo[a]pyrene glucuronides in cell lines derived from the human aerodigestive tract. Carcinogenesis. 2004 Academic Article GET IT
Times cited: 12

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Background

education and training

Ph.D., University of California, Berkeley 1963
B.Sc., Hebrew University (Israel) 1958

Contact

full name

Levy Kopelovich

primary email

lek2010@med.cornell.edu

VIVO Weill Cornell Medical College

Levy Kopelovich Adjunct Professor of Biochemistry in Medicine

Publications

selected publications

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Background

education and training

Contact

full name

primary email