Dactyloditerpenol acetate, a new prenylbisabolane-type diterpene from Aplysia dactylomela with significant in vitro anti-neuroinflammatory activity. Academic Article uri icon

Overview

abstract

  • A new regular diterpene possessing an unusual 1,6-anti-3-methylcyclohex-2-en-1-ol ring system, dactyloditerpenol acetate (1), has been extracted from the tropical sea hare Aplysia dactylomela and its stereostructure elucidated by spectroscopic methods. The absolute configuration of 1 was determined as 1S, 6S, 7R, 10S, and 11R by application of Kishi's method for the assignment of absolute configuration of alcohols. The new diterpene potently inhibited in vitro thromboxane B2 (TXB2) (IC50 0.4μM) and superoxide anion (O2(-)) (IC50 1μM) generation from Escherichia coli lipopolysaccharide (LPS)-activated rat neonatal microglia, with concomitant low short-term toxicity.

publication date

  • November 14, 2013

Research

keywords

  • Anti-Inflammatory Agents, Non-Steroidal
  • Aplysia
  • Diterpenes
  • Superoxides
  • Thromboxane B2

Identity

PubMed Central ID

  • PMC4249741

Scopus Document Identifier

  • 84891496744

Digital Object Identifier (DOI)

  • 10.1016/j.bmcl.2013.11.008

PubMed ID

  • 24279991

Additional Document Info

volume

  • 24

issue

  • 1