Tumor necrosis factor induces expression of MHC class I antigens on mouse astrocytes. Academic Article uri icon

Overview

abstract

  • The effect of tumor necrosis factor (TNF) on expression of major histocompatibility complex (MHC) antigens was examined in mouse glial cells in vitro. TNF induced MHC class I, but not class II, antigen expression on the surface of astrocytes but not on oligodendrocytes. Glial cells do not normally express detectable amounts of MHC antigens. Thus TNF may play a role in the immunopathogenesis of neurologic diseases that involve MHC class I-restricted reactions.

publication date

  • June 1, 1988

Research

keywords

  • Astrocytes
  • HLA Antigens
  • Tumor Necrosis Factor-alpha

Identity

PubMed Central ID

  • PMC7120086

Scopus Document Identifier

  • 0023917746

PubMed ID

  • 2452831

Additional Document Info

volume

  • 18

issue

  • 3