Biobanks and personalized medicine. Review uri icon



  • We provide a mini-review of how biobanks can support clinical genetics in the era of personalized medicine. We discuss types of biobanks, including disease specific and general biobanks not focused on one disease. We present considerations in setting up a biobank, including consenting and governance, biospecimens, risk factor and related data, informatics, and linkage to electronic health records for phenotyping. We also discuss the uses of biobanks and ongoing considerations, including genotype-driven recruitment, investigations of gene-environment associations, and the re-use of data generated from studies. Finally, we present a brief discussion of some of the unresolved issues, such as return of research results and sustaining biobanks over time. In summary, carefully designed biobanks can provide critical research and infrastructure support for clinical genetics in the era of personalized medicine.

publication date

  • March 27, 2014



  • Biological Specimen Banks
  • Computational Biology
  • Databases, Genetic
  • Genetics, Medical
  • Precision Medicine


PubMed Central ID

  • PMC4898781

Scopus Document Identifier

  • 84901694951

Digital Object Identifier (DOI)

  • 10.1111/cge.12370

PubMed ID

  • 24588254

Additional Document Info


  • 86


  • 1