The translational revolution and use of biologics in patients with inflammatory skin diseases. Review uri icon

Overview

abstract

  • Psoriasis and atopic dermatitis (AD) are common inflammatory skin diseases characterized by immune-mediated inflammation and abnormal keratinocyte differentiation. Although T-cell infiltration characterizes both diseases, T-cell polarization differs. Psoriasis is currently the best model for translational medicine because many targeted therapeutics have been developed and testing of targeted therapeutics has cemented psoriasis as IL-23/TH17 polarized. In patients with AD, although therapeutic development is approximately a decade behind that in patients with psoriasis, there is now active development and testing of targeted therapeutics against various immune axes (TH2, TH22, and IL-23/TH17). These clinical trials and subsequent molecular analyses using human samples will be able to clarify the relative roles of polar cytokines in patients with AD.

publication date

  • December 23, 2014

Research

keywords

  • Anti-Inflammatory Agents
  • Biological Factors
  • Dermatitis

Identity

Scopus Document Identifier

  • 84922352134

Digital Object Identifier (DOI)

  • 10.1016/j.jaci.2014.11.015

PubMed ID

  • 25541257

Additional Document Info

volume

  • 135

issue

  • 2