Evaluation of hypoxia with copper-labeled diacetyl-bis(N-methylthiosemicarbazone). Review uri icon

Overview

abstract

  • Imaging of hypoxia is important in many diseases states in oncology, cardiology, and neurology. The radiopharmaceutical, copper-labeled diacetyl-bis(N-methylthiosemicarbazone), has been used to assess hypoxia in many studies. In particular, copper-labeled diacetyl-bis(N-methylthiosemicarbazone) has been used in oncologic settings to investigate tumor hypoxia and the role of this parameter in response to therapy and outcome. Some groups have conducted imaging studies assessing the role of hypoxia in cardiovascular and neurologic disorders. Additionally, several groups have made significant progress into understanding the mechanism by which this compound accumulates in cells. Multiple preclinical and clinical studies have been conducted, shedding light on the importance of careful image analysis when using this tracer. This review article focuses on the recent preclinical and clinical studies with this tracer.

publication date

  • March 1, 2015

Research

keywords

  • Coordination Complexes
  • Copper Radioisotopes
  • Molecular Imaging
  • Thiosemicarbazones

Identity

PubMed Central ID

  • PMC4339100

Scopus Document Identifier

  • 84924050395

Digital Object Identifier (DOI)

  • 10.1053/j.semnuclmed.2014.10.003

PubMed ID

  • 25704389

Additional Document Info

volume

  • 45

issue

  • 2