Metabolic-epigenetic coupling in osteoclast differentiation. uri icon

Overview

abstract

  • Osteoclasts are required for bone resorption. A new study in mice indicates that osteoclast differentiation is stabilized by DNA methylation at Irf8 (encoding interferon regulatory factor 8) mediated by DNA methyltransferase 3a (Dnmt3a), which suppresses Irf8 gene expression. The activity of Dnmt3 in osteoclasts requires elevated oxidative metabolism.

publication date

  • March 1, 2015

Research

keywords

  • Bone Resorption
  • Cell Differentiation
  • DNA (Cytosine-5-)-Methyltransferases
  • Osteoclasts
  • Osteogenesis
  • RANK Ligand
  • S-Adenosylmethionine

Identity

PubMed Central ID

  • PMC4795459

Scopus Document Identifier

  • 84924412375

Digital Object Identifier (DOI)

  • 10.1038/nm.3815

PubMed ID

  • 25742453

Additional Document Info

volume

  • 21

issue

  • 3