A matter of access. Nucleosome disassembly from gene promoters is the central goal of transcriptional activators. Academic Article uri icon

Overview

abstract

  • The mechanism whereby transcriptional activators facilitate transcription activation has been debated. Our recent genome-wide profiling of gene expression during aging, where nucleosomes are depleted, indicates that the function of seemingly all transcriptional activators is to trigger nucleosome disassembly from promoters to allow the general transcription machinery access to the DNA.

publication date

  • January 1, 2014

Research

keywords

  • DNA-Binding Proteins
  • Fungal Proteins
  • Nucleosomes
  • Promoter Regions, Genetic
  • Transcriptional Activation
  • Yeasts

Identity

PubMed Central ID

  • PMC4215176

Scopus Document Identifier

  • 84904962430

Digital Object Identifier (DOI)

  • 10.4161/trns.29355

PubMed ID

  • 25764221

Additional Document Info

volume

  • 5

issue

  • 2