selected publications
- Transcriptional inhibition after irradiation occurs preferentially at highly expressed genes in a manner dependent on cell cycle progression. eLife. 2024 Academic Article GET IT
- Senataxin and DNA-PKcs Redundantly Promote Non-Homologous End Joining Repair of DNA Double Strand Breaks During V(D)J Recombination. 2024 GET IT
- Transcriptional inhibition after irradiation occurs preferentially at highly expressed genes in a manner dependent on cell cycle progression. 2023 GET IT
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A novel single alpha-helix DNA-binding domain in CAF-1 promotes gene silencing and DNA damage survival through tetrasome-length DNA selectivity and spacer function.
eLife.
2023
Academic Article
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Times cited: 2 - Editorial: Germ cell development and reproductive aging. Frontiers in cell and developmental biology. 2022 Editorial Article GET IT
- A Simple, Improved Method for Scarless Genome Editing of Budding Yeast Using CRISPR-Cas9. Methods and protocols. 2022 Academic Article GET IT
- The Chromatin Landscape Channels DNA Double-Strand Breaks to Distinct Repair Pathways. Frontiers in cell and developmental biology. 2022 Review GET IT
- A Flow Cytometry-Based Method for Analyzing DNA End Resection in G0- and G1-Phase Mammalian Cells. Bio-protocol. 2022 Academic Article GET IT
- DNA-PK promotes DNA end resection at DNA double strand breaks in G0 cells. eLife. 2022 Academic Article GET IT
- A Proximity Ligation Method to Detect Proteins Bound to Single-Stranded DNA after DNA End Resection at DNA Double-Strand Breaks. Methods and protocols. 2021 Academic Article GET IT
- LIN37-DREAM prevents DNA end resection and homologous recombination at DNA double-strand breaks in quiescent cells. eLife. 2021 Academic Article GET IT
- The RNF8 and RNF168 Ubiquitin Ligases Regulate Pro- and Anti-Resection Activities at Broken DNA Ends During Non-Homologous End Joining. DNA repair. 2021 Academic Article GET IT
- Sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) activity is required for V(D)J recombination. The Journal of experimental medicine. 2021 Academic Article GET IT
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Selenium supplementation inhibits IGF-1 signaling and confers methionine restriction-like healthspan benefits to mice.
eLife.
2021
Academic Article
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Times cited: 19 -
Dynamic Incorporation of Histone H3 Variants into Chromatin Is Essential for Acquisition of Aggressive Traits and Metastatic Colonization.
Cancer cell.
2019
Academic Article
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Times cited: 65 -
XLF and H2AX function in series to promote replication fork stability.
The Journal of cell biology.
2019
Academic Article
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Times cited: 15 -
Is Gcn4-induced autophagy the ultimate downstream mechanism by which hormesis extends yeast replicative lifespan?.
Current genetics.
2019
Information Resource
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Times cited: 17 -
Ssd1 and Gcn2 suppress global translation efficiency in replicatively aged yeast while their activation extends lifespan.
eLife.
2018
Academic Article
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Times cited: 53 -
The histone chaperone ASF1 regulates the activation of ATM and DNA-PKcs in response to DNA double-strand breaks.
Cell cycle (Georgetown, Tex.).
2018
Academic Article
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Times cited: 6 -
MRI Is a DNA Damage Response Adaptor during Classical Non-homologous End Joining.
Molecular cell.
2018
Academic Article
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Times cited: 71 -
The Histone Chaperones ASF1 and CAF-1 Promote MMS22L-TONSL-Mediated Rad51 Loading onto ssDNA during Homologous Recombination in Human Cells.
Molecular cell.
2018
Academic Article
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Times cited: 63 -
Suboptimal extracellular pH values alter DNA damage response to induced double-strand breaks.
FEBS open bio.
2018
Academic Article
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Times cited: 10 -
Impaired cohesion and homologous recombination during replicative aging in budding yeast.
Science advances.
2018
Academic Article
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Times cited: 31 -
The role of autophagy in the regulation of yeast life span.
Annals of the New York Academy of Sciences.
2018
Information Resource
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Times cited: 31 -
Proteomic identification of histone post-translational modifications and proteins enriched at a DNA double-strand break.
Nucleic acids research.
2017
Academic Article
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Times cited: 10 -
The integrated stress response in budding yeast lifespan extension.
Microbial cell (Graz, Austria).
2017
Information Resource
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Times cited: 42 -
Delineation of the role of chromatin assembly and the Rtt101Mms1 E3 ubiquitin ligase in DNA damage checkpoint recovery in budding yeast.
PloS one.
2017
Academic Article
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Times cited: 13 -
Thinking Outside the Cell: Replicating Replication In Vitro.
Molecular cell.
2017
Article
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Times cited: 1 -
Deficiency of XLF and PAXX prevents DNA double-strand break repair by non-homologous end joining in lymphocytes.
Cell cycle (Georgetown, Tex.).
2016
Academic Article
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Times cited: 34 - The Cac1 subunit of histone chaperone CAF-1 organizes CAF-1-H3/H4 architecture and tetramerizes histones. eLife. 2016 Article GET IT
- The Cac1 subunit of histone chaperone CAF-1 organizes CAF-1-H3/H4 architecture and tetramerizes histones. eLife. 2016 Academic Article GET IT
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Epigenetics and aging.
Science advances.
2016
Information Resource
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Times cited: 558 -
Nucleosome disassembly during human non-homologous end joining followed by concerted HIRA- and CAF-1-dependent reassembly.
eLife.
2016
Academic Article
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Times cited: 54 -
Excess free histone H3 localizes to centrosomes for proteasome-mediated degradation during mitosis in metazoans.
Cell cycle (Georgetown, Tex.).
2016
Academic Article
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Times cited: 1 -
The Commercial Antibodies Widely Used to Measure H3 K56 Acetylation Are Non-Specific in Human and Drosophila Cells.
PloS one.
2016
Academic Article
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Times cited: 10 -
TIE2-mediated tyrosine phosphorylation of H4 regulates DNA damage response by recruiting ABL1.
Science advances.
2016
Academic Article
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Times cited: 32 -
Mutations that prevent or mimic persistent post-translational modifications of the histone H3 globular domain cause lethality and growth defects in Drosophila.
Epigenetics & chromatin.
2016
Academic Article
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Times cited: 13 -
Aurora-A mediated histone H3 phosphorylation of threonine 118 controls condensin I and cohesin occupancy in mitosis.
eLife.
2016
Academic Article
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Times cited: 22 -
The Overlooked Fact: Fundamental Need for Spike-In Control for Virtually All Genome-Wide Analyses.
Molecular and cellular biology.
2015
Academic Article
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Times cited: 121 -
Development of novel cellular histone-binding and chromatin-displacement assays for bromodomain drug discovery.
Epigenetics & chromatin.
2015
Academic Article
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Times cited: 31 -
HDAC1,2 inhibition impairs EZH2- and BBAP-mediated DNA repair to overcome chemoresistance in EZH2 gain-of-function mutant diffuse large B-cell lymphoma.
Oncotarget.
2015
Academic Article
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Times cited: 36 -
The BRCA1-interacting protein Abraxas is required for genomic stability and tumor suppression.
Cell reports.
2014
Academic Article
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Times cited: 34 -
MOF phosphorylation by ATM regulates 53BP1-mediated double-strand break repair pathway choice.
Cell reports.
2014
Academic Article
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Times cited: 56 -
Binding of the histone chaperone ASF1 to the CBP bromodomain promotes histone acetylation.
Proceedings of the National Academy of Sciences of the United States of America.
2014
Academic Article
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Times cited: 56 -
Nucleosome loss leads to global transcriptional up-regulation and genomic instability during yeast aging.
Genes & development.
2014
Academic Article
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Times cited: 241 -
A matter of access. Nucleosome disassembly from gene promoters is the central goal of transcriptional activators.
Transcription.
2014
Academic Article
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Times cited: 4 -
Mitotic phosphorylation of histone H3 threonine 80.
Cell cycle (Georgetown, Tex.).
2013
Academic Article
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Times cited: 31 - Epigenetics and Chromatin: Interactions and processes Boston, MA, USA. 11-13 March 2013. Abstracts. Epigenetics & chromatin. 2013 Academic Article GET IT
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DANPOS: dynamic analysis of nucleosome position and occupancy by sequencing.
Genome research.
2012
Academic Article
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Times cited: 290 -
The C terminus of the histone chaperone Asf1 cross-links to histone H3 in yeast and promotes interaction with histones H3 and H4.
Molecular and cellular biology.
2012
Academic Article
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Times cited: 19 -
The conformational flexibility of the C-terminus of histone H4 promotes histone octamer and nucleosome stability and yeast viability.
Epigenetics & chromatin.
2012
Academic Article
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Times cited: 18 -
Epigenetic regulation of genomic integrity.
Chromosoma.
2012
Information Resource
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Times cited: 37 -
Chromatin structure as a mediator of aging.
FEBS letters.
2010
Information Resource
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Times cited: 159 -
Elevated histone expression promotes life span extension.
Molecular cell.
2010
Academic Article
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Times cited: 332 -
The histone shuffle: histone chaperones in an energetic dance.
Trends in biochemical sciences.
2010
Information Resource
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Times cited: 145 -
Chaperoning histones during DNA replication and repair.
Cell.
2010
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Times cited: 274 -
Epigenetic inheritance of an inducibly nucleosome-depleted promoter and its associated transcriptional state in the apparent absence of transcriptional activators.
Epigenetics & chromatin.
2009
Academic Article
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Times cited: 8 -
FACT and the proteasome promote promoter chromatin disassembly and transcriptional initiation.
The Journal of biological chemistry.
2009
Academic Article
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Times cited: 54 -
CBP/p300-mediated acetylation of histone H3 on lysine 56.
Nature.
2009
Academic Article
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Times cited: 596 -
Chromatin reassembly signals the end of DNA repair.
Cell cycle (Georgetown, Tex.).
2008
Information Resource
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Times cited: 26 -
Acetylated lysine 56 on histone H3 drives chromatin assembly after repair and signals for the completion of repair.
Cell.
2008
Academic Article
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Times cited: 339 -
Acetylation in the globular core of histone H3 on lysine-56 promotes chromatin disassembly during transcriptional activation.
Proceedings of the National Academy of Sciences of the United States of America.
2008
Academic Article
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Times cited: 179 -
Chromatin disassembly from the PHO5 promoter is essential for the recruitment of the general transcription machinery and coactivators.
Molecular and cellular biology.
2007
Academic Article
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Times cited: 75 -
Transcriptional regulation by chromatin disassembly and reassembly.
Current opinion in genetics & development.
2007
Information Resource
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Times cited: 67 -
The histone chaperone anti-silencing function 1 stimulates the acetylation of newly synthesized histone H3 in S-phase.
The Journal of biological chemistry.
2006
Academic Article
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Times cited: 74 -
Structural basis for the histone chaperone activity of Asf1.
Cell.
2006
Academic Article
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Times cited: 369 - Global replication-independent histone H4 exchange in budding yeast. Eukaryotic cell. 2006 Academic Article GET IT
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Dominant mutants of the Saccharomyces cerevisiae ASF1 histone chaperone bypass the need for CAF-1 in transcriptional silencing by altering histone and Sir protein recruitment.
Genetics.
2006
Academic Article
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Times cited: 20 -
Transcriptional activators are dispensable for transcription in the absence of Spt6-mediated chromatin reassembly of promoter regions.
Molecular cell.
2006
Academic Article
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Times cited: 137 -
The histone chaperone ASF1 localizes to active DNA replication forks to mediate efficient DNA replication.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2006
Academic Article
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Times cited: 59 -
ASF1 binds to a heterodimer of histones H3 and H4: a two-step mechanism for the assembly of the H3-H4 heterotetramer on DNA.
Biochemistry.
2005
Academic Article
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Times cited: 114 -
The yeast histone chaperone chromatin assembly factor 1 protects against double-strand DNA-damaging agents.
Genetics.
2005
Academic Article
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Times cited: 62 -
Functional conservation and specialization among eukaryotic anti-silencing function 1 histone chaperones.
Eukaryotic cell.
2005
Academic Article
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Times cited: 33 -
Localized histone acetylation and deacetylation triggered by the homologous recombination pathway of double-strand DNA repair.
Molecular and cellular biology.
2005
Academic Article
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Times cited: 253 -
The histone chaperone anti-silencing function 1 is a global regulator of transcription independent of passage through S phase.
Molecular and cellular biology.
2005
Academic Article
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Times cited: 47 -
Activation of the DNA damage checkpoint in yeast lacking the histone chaperone anti-silencing function 1.
Molecular and cellular biology.
2004
Academic Article
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Times cited: 85 -
The histone chaperone Asf1p mediates global chromatin disassembly in vivo.
The Journal of biological chemistry.
2004
Academic Article
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Times cited: 91 -
Chromatin disassembly mediated by the histone chaperone Asf1 is essential for transcriptional activation of the yeast PHO5 and PHO8 genes.
Molecular cell.
2004
Academic Article
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Times cited: 250 -
Interaction between the Drosophila CAF-1 and ASF1 chromatin assembly factors.
Molecular and cellular biology.
2001
Academic Article
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Times cited: 180 -
The RCAF complex mediates chromatin assembly during DNA replication and repair.
Nature.
1999
Academic Article
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Times cited: 432 -
The "dark side" of chromatin remodeling: repressive effects on transcription.
Cell.
1999
Information Resource
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Times cited: 200 - Replacement of the herpes simplex virus type 1 Vmw175 DNA binding domain with its varicella-zoster virus counterpart results in a protein with novel regulatory properties that can support virus growth. The Journal of general virology. 1997 Academic Article GET IT
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The p55 subunit of Drosophila chromatin assembly factor 1 is homologous to a histone deacetylase-associated protein.
Molecular and cellular biology.
1996
Academic Article
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Times cited: 122 -
ATP-facilitated chromatin assembly with a nucleoplasmin-like protein from Drosophila melanogaster.
The Journal of biological chemistry.
1996
Academic Article
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Times cited: 85 -
The DNA binding domains of the varicella-zoster virus gene 62 and herpes simplex virus type 1 ICP4 transactivator proteins heterodimerize and bind to DNA.
Nucleic acids research.
1994
Academic Article
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Times cited: 19 -
Mutation of a single lysine residue severely impairs the DNA recognition and regulatory functions of the VZV gene 62 transactivator protein.
Nucleic acids research.
1994
Academic Article
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Times cited: 24 -
An epitope within the DNA-binding domain of the herpes simplex virus immediate early protein Vmw175 is conserved in the varicella-zoster virus gene 62 protein.
The Journal of general virology.
1993
Academic Article
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Times cited: 15 -
The DNA binding domain of the varicella-zoster virus gene 62 protein interacts with multiple sequences which are similar to the binding site of the related protein of herpes simplex virus type 1.
Nucleic acids research.
1993
Academic Article
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Times cited: 33