Anchoring Chromatin Loops to Cancer. uri icon

Overview

abstract

  • Although some genomic rearrangements are caused by replication or transcription, the etiology of others is unclear. Reporting in Cell, Canela et al. (2017) reveal that type II topoisomerase-mediated release of torsional strain at chromosomal loop anchors generates DNA double-strand breaks that drive multiple oncogenic translocations in a transcription-independent manner.

publication date

  • August 7, 2017

Research

keywords

  • Chromatin
  • DNA Breaks, Double-Stranded

Identity

PubMed Central ID

  • PMC5859922

Scopus Document Identifier

  • 85026555611

Digital Object Identifier (DOI)

  • 10.1016/j.devcel.2017.07.013

PubMed ID

  • 28787588

Additional Document Info

volume

  • 42

issue

  • 3