Chaperoning histones during DNA replication and repair. Review uri icon

Overview

abstract

  • Nuclear DNA is tightly packaged into chromatin, which profoundly influences DNA replication, transcription, repair, and recombination. The extensive interactions between the basic histone proteins and acidic DNA make the nucleosomal unit of chromatin a highly stable entity. For the cellular machinery to access the DNA, the chromatin must be unwound and the DNA cleared of histone proteins. Conversely, the DNA has to be repackaged into chromatin afterward. This review focuses on the roles of the histone chaperones in assembling and disassembling chromatin during the processes of DNA replication and repair.

publication date

  • January 22, 2010

Research

keywords

  • Chromatin Assembly and Disassembly
  • DNA Repair
  • DNA Replication
  • Histone Chaperones

Identity

PubMed Central ID

  • PMC3433953

Scopus Document Identifier

  • 74549138158

Digital Object Identifier (DOI)

  • 10.1016/j.cell.2010.01.004

PubMed ID

  • 20141833

Additional Document Info

volume

  • 140

issue

  • 2