Cell

publication venue for

Human iPSC 4R tauopathy model uncovers modifiers of tau propagation. 2024
Therapeutic application of human type 2 innate lymphoid cells via induction of granzyme B-mediated tumor cell death. 2024
Sensory neurons promote immune homeostasis in the lung. 2023
SnapShot: Target-directed miRNA degradation.. 186. 2023
Epigenetic memory of coronavirus infection in innate immune cells and their progenitors.. 186. 2023
T cell immunotherapies engage neutrophils to eliminate tumor antigen escape variants.. 186. 2023
HIV-1 remission and possible cure in a woman after haplo-cord blood transplant.. 186. 2023
When IL-17 gets on your nerves.. 186. 2023
Comprehensive maturity of nuclear pore complexes regulates zygotic genome activation. 2022
A Zika virus-specific IgM elicited in pregnancy exhibits ultrapotent neutralization. 2022
Genomic architecture of autism from comprehensive whole-genome sequence annotation.. 185. 2022
Gut-innervating nociceptors regulate the intestinal microbiota to promote tissue protection.. 185. 2022
X-linked ubiquitin-specific peptidase 11 increases tauopathy vulnerability in women.. 185. 2022
A pan-cancer mycobiome analysis reveals fungal involvement in gastrointestinal and lung tumors.. 185. 2022
Cholesterol and matrisome pathways dysregulated in astrocytes and microglia.. 185. 2022
GPCR-mediated β-arrestin activation deconvoluted with single-molecule precision.. 185. 2022
Reconstruction of neocortex: Organelles, compartments, cells, circuits, and activity.. 185. 2022
Mucosal fungi promote gut barrier function and social behavior via Type 17 immunity. 2022
Genomic characterization of metastatic patterns from prospective clinical sequencing of 25,000 patients.. 185. 2022
Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration.. 185. 2022
Genetic manipulation of gut microbes enables single-gene interrogation in a complex microbiome. 2022
EMSY inhibits homologous recombination repair and the interferon response, promoting lung cancer immune evasion.. 185. 2021
The emergence and ongoing convergent evolution of the SARS-CoV-2 N501Y lineages.. 184. 2021
Dysregulation of ILC3s unleashes progression and immunotherapy resistance in colon cancer. 2021
Targeting Pin1 renders pancreatic cancer eradicable by synergizing with immunochemotherapy.. 184. 2021
Erythroid mitochondrial retention triggers myeloid-dependent type I interferon in human SLE.. 184. 2021
Genome-wide gene expression tuning reveals diverse vulnerabilities of M. tuberculosis.. 184. 2021
Preservation of vision after CaMKII-mediated protection of retinal ganglion cells.. 184. 2021
Pharmacologic modulation of RNA splicing enhances anti-tumor immunity.. 184. 2021
Endogenous retroviruses promote homeostatic and inflammatory responses to the microbiota.. 184. 2021
A local regulatory T cell feedback circuit maintains immune homeostasis by pruning self-activated T cells.. 184. 2021
A global metagenomic map of urban microbiomes and antimicrobial resistance.. 184. 2021
The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer.. 184. 2021
Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome.. 184. 2021
Prefrontal deep projection neurons enable cognitive flexibility via persistent feedback monitoring.. 184. 2021
Reducing acetylated tau is neuroprotective in brain injury.. 184. 2021
Early introductions and transmission of SARS-CoV-2 variant B.1.1.7 in the United States.. 184. 2021
Human gut mycobiota tune immunity via CARD9-dependent induction of anti-fungal IgG antibodies.. 184. 2021
p53 is a central regulator driving neurodegeneration caused by C9orf72 poly(PR).. 184. 2021
TMEM41B Is a Pan-flavivirus Host Factor.. 184. 2020
Comprehensive Multi-omics Analysis Reveals Mitochondrial Stress as a Central Biological Hub for Spaceflight Impact.. 183. 2020
Key Parameters of Tumor Epitope Immunogenicity Revealed Through a Consortium Approach Improve Neoantigen Prediction.. 183. 2020
Distinct Classes of Complex Structural Variation Uncovered across Thousands of Cancer Genome Graphs.. 183. 2020
Noninvasive Early Identification of Therapeutic Benefit from Immune Checkpoint Inhibition.. 183. 2020
Macrophages Maintain Epithelium Integrity by Limiting Fungal Product Absorption.. 183. 2020
Diet Diurnally Regulates Small Intestinal Microbiome-Epithelial-Immune Homeostasis and Enteritis.. 182. 2020
Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers.. 182. 2020
TBL1XR1 Mutations Drive Extranodal Lymphoma by Inducing a Pro-tumorigenic Memory Fate.. 182. 2020
Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived Eicosanoids.. 181. 2020
A Unified Model for the Function of YTHDF Proteins in Regulating m⁶A-Modified mRNA.. 181. 2020
Illuminating Genetic Mysteries of the Dead Sea Scrolls.. 181. 2020
Interrogation of the Microenvironmental Landscape in Brain Tumors Reveals Disease-Specific Alterations of Immune Cells.. 181. 2020
Raymond L. Erikson (1936-2020).. 181. 2020
SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract.. 182. 2020
Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19.. 181. 2020
Passenger Mutations in More Than 2,500 Cancer Genomes: Overall Molecular Functional Impact and Consequences.. 180. 2020
Tissue Determinants of Human NK Cell Development, Function, and Residence.. 180. 2020
Restriction of HIV-1 Escape by a Highly Broad and Potent Neutralizing Antibody.. 180. 2020
SnapShot: Splicing Alterations in Cancer.. 180. 2020
Attacking Latent HIV with convertibleCAR-T Cells, a Highly Adaptable Killing Platform.. 179. 2019
Transcriptional Basis of Mouse and Human Dendritic Cell Heterogeneity.. 179. 2019
Synergistic Coordination of Chromatin Torsional Mechanics and Topoisomerase Activity.. 179. 2019
Herceptin: A First Assault on Oncogenes that Launched a Revolution.. 179. 2019
Antibiotics-Driven Gut Microbiome Perturbation Alters Immunity to Vaccines in Humans.. 178. 2019
Reconstruction of 1,000 Projection Neurons Reveals New Cell Types and Organization of Long-Range Connectivity in the Mouse Brain.. 179. 2019
The Bone Marrow Protects and Optimizes Immunological Memory during Dietary Restriction.. 178. 2019
Opposing Functions of Interferon Coordinate Adaptive and Innate Immune Responses to Cancer Immune Checkpoint Blockade.. 178. 2019
The Cytoplasmic DNA Sensor cGAS Promotes Mitotic Cell Death.. 178. 2019
Regulation of Energy Expenditure by Brainstem GABA Neurons.. 178. 2019
Fc Characteristics Mediate Selective Placental Transfer of IgG in HIV-Infected Women.. 178. 2019
Fc Glycan-Mediated Regulation of Placental Antibody Transfer.. 178. 2019
Selenium Drives a Transcriptional Adaptive Program to Block Ferroptosis and Treat Stroke.. 177. 2019
Neuronal Dynamics Regulating Brain and Behavioral State Transitions.. 177. 2019
Phenotypic Landscape of Schizophrenia-Associated Genes Defines Candidates and Their Shared Functions.. 177. 2019
Characterizing Mutational Signatures in Human Cancer Cell Lines Reveals Episodic APOBEC Mutagenesis.. 176. 2019
p53 Represses the Mevalonate Pathway to Mediate Tumor Suppression.. 176. 2018
Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids.. 175. 2018
Mitochondrial One-Carbon Pathway Supports Cytosolic Folate Integrity in Cancer Cells.. 175. 2018
Spatiotemporal Control of CNS Myelination by Oligodendrocyte Programmed Cell Death through the TFEB-PUMA Axis.. 175. 2018
The 7q11.23 Protein DNAJC30 Interacts with ATP Synthase and Links Mitochondria to Brain Development.. 175. 2018
An Atypical Parvovirus Drives Chronic Tubulointerstitial Nephropathy and Kidney Fibrosis.. 175. 2018
Mutations in Disordered Regions Can Cause Disease by Creating Dileucine Motifs.. 175. 2018
Small Molecules Co-targeting CKIα and the Transcriptional Kinases CDK7/9 Control AML in Preclinical Models.. 175. 2018
Single-Cell Map of Diverse Immune Phenotypes in the Breast Tumor Microenvironment.. 174. 2018
A Somatically Acquired Enhancer of the Androgen Receptor Is a Noncoding Driver in Advanced Prostate Cancer.. 174. 2018
Developmental Origin Governs CD8⁺ T Cell Fate Decisions during Infection.. 174. 2018
A Network of Noncoding Regulatory RNAs Acts in the Mammalian Brain.. 174. 2018
Digital Museum of Retinal Ganglion Cells with Dense Anatomy and Physiology.. 173. 2018
Disease Heritability Inferred from Familial Relationships Reported in Medical Records.. 173. 2018
Cancer-Germline Antigen Expression Discriminates Clinical Outcome to CTLA-4 Blockade.. 173. 2018
Comprehensive Characterization of Cancer Driver Genes and Mutations.. 173. 2018
Influenza Infection in Humans Induces Broadly Cross-Reactive and Protective Neuraminidase-Reactive Antibodies.. 173. 2018
Tumor Evolution and Drug Response in Patient-Derived Organoid Models of Bladder Cancer.. 173. 2018
Brain-wide Electrical Spatiotemporal Dynamics Encode Depression Vulnerability.. 173. 2018
Development of Concurrent Retinotopic Maps in the Fly Motion Detection Circuit.. 173. 2018
A Non-catalytic Function of SETD1A Regulates Cyclin K and the DNA Damage Response.. 172. 2018
TBK1 at the Crossroads of Inflammation and Energy Homeostasis in Adipose Tissue.. 172. 2018
Human ADAR1 Prevents Endogenous RNA from Triggering Translational Shutdown.. 172. 2018
Non-classical Immunity Controls Microbiota Impact on Skin Immunity and Tissue Repair.. 172. 2018
LXR/ApoE Activation Restricts Innate Immune Suppression in Cancer.. 172. 2018
CD19 CAR T Cells.. 171. 2017
Intrinsic Immunity Shapes Viral Resistance of Stem Cells.. 172. 2017
Mfd Dynamically Regulates Transcription via a Release and Catch-Up Mechanism.. 172. 2017
Post-transcriptional Regulation of De Novo Lipogenesis by mTORC1-S6K1-SRPK2 Signaling.. 171. 2017
STING Senses Microbial Viability to Orchestrate Stress-Mediated Autophagy of the Endoplasmic Reticulum.. 171. 2017
Tumor and Microenvironment Evolution during Immunotherapy with Nivolumab.. 171. 2017
Genetic and Functional Drivers of Diffuse Large B Cell Lymphoma.. 171. 2017
Mitochondrial Fission Promotes the Continued Clearance of Apoptotic Cells by Macrophages.. 171. 2017
Excess Translation of Epigenetic Regulators Contributes to Fragile X Syndrome and Is Alleviated by Brd4 Inhibition.. 170. 2017
Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression.. 170. 2017
Non-neutralizing Antibodies Alter the Course of HIV-1 Infection In Vivo.. 170. 2017
IFNγ-Dependent Tissue-Immune Homeostasis Is Co-opted in the Tumor Microenvironment.. 170. 2017
Interferon-γ Drives T_reg Fragility to Promote Anti-tumor Immunity.. 169. 2017
Regulatory T Cells in Skin Facilitate Epithelial Stem Cell Differentiation.. 169. 2017
Recurrent Potent Human Neutralizing Antibodies to Zika Virus in Brazil and Mexico.. 169. 2017
Stem Cell Lineage Infidelity Drives Wound Repair and Cancer.. 169. 2017
Complement Component 3 Adapts the Cerebrospinal Fluid for Leptomeningeal Metastasis.. 168. 2017
Discovery of Reactive Microbiota-Derived Metabolites that Inhibit Host Proteases.. 168. 2017
Genomic Nucleosome Organization Reconstituted with Pure Proteins.. 167. 2016
Loss of the HVEM Tumor Suppressor in Lymphoma and Restoration by Modified CAR-T Cells.. 167. 2016
Memory of Inflammation in Regulatory T Cells.. 166. 2016
Irreversible APC(Cdh1) Inactivation Underlies the Point of No Return for Cell-Cycle Entry.. 166. 2016
Multi-organ Site Metastatic Reactivation Mediated by Non-canonical Discoidin Domain Receptor 1 Signaling.. 166. 2016
Mapping of Brain Activity by Automated Volume Analysis of Immediate Early Genes.. 165. 2016
A Glial K/Cl Transporter Controls Neuronal Receptive Ending Shape by Chloride Inhibition of an rGC.. 165. 2016
RNA Polymerase II Regulates Topoisomerase 1 Activity to Favor Efficient Transcription.. 165. 2016
Personalized Immunomonitoring Uncovers Molecular Networks that Stratify Lupus Patients.. 165. 2016
NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria.. 164. 2016
New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs.. 164. 2016
Axon Degeneration Gated by Retrograde Activation of Somatic Pro-apoptotic Signaling.. 164. 2016
Multiplexed Intact-Tissue Transcriptional Analysis at Cellular Resolution.. 164. 2016
A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human.. 164. 2016
Immunogenicity of Stabilized HIV-1 Envelope Trimers with Reduced Exposure of Non-neutralizing Epitopes.. 163. 2015
SPED Light Sheet Microscopy: Fast Mapping of Biological System Structure and Function.. 163. 2015
The Molecular Taxonomy of Primary Prostate Cancer.. 163. 2015
Relaxation of Loaded ESCRT-III Spiral Springs Drives Membrane Deformation.. 163. 2015
5' UTR m(6)A Promotes Cap-Independent Translation.. 163. 2015
Sympathetic neuro-adipose connections mediate leptin-driven lipolysis.. 163. 2015
A Distinct Function of Regulatory T Cells in Tissue Protection.. 162. 2015
Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses.. 162. 2015
The Nuclear Pore-Associated TREX-2 Complex Employs Mediator to Regulate Gene Expression.. 162. 2015
Apc Restoration Promotes Cellular Differentiation and Reestablishes Crypt Homeostasis in Colorectal Cancer.. 161. 2015
Glucose Uptake and Runx2 Synergize to Orchestrate Osteoblast Differentiation and Bone Formation.. 161. 2015
Immunization for HIV-1 Broadly Neutralizing Antibodies in Human Ig Knockin Mice.. 161. 2015
ER Stress Sensor XBP1 Controls Anti-tumor Immunity by Disrupting Dendritic Cell Homeostasis.. 161. 2015
Integrative clinical genomics of advanced prostate cancer.. 161. 2015
Mitochondrial ClpX Activates a Key Enzyme for Heme Biosynthesis and Erythropoiesis.. 161. 2015
The BRAF pseudogene functions as a competitive endogenous RNA and induces lymphoma in vivo.. 161. 2015
Hepatitis C virus RNA functionally sequesters miR-122.. 160. 2015
A serpin shapes the extracellular environment to prevent influenza A virus maturation.. 160. 2015
HIV-1 integration landscape during latent and active infection.. 160. 2015
Extracellular metabolic energetics can promote cancer progression.. 160. 2015
Pathological axonal death through a MAPK cascade that triggers a local energy deficit.. 160. 2015
Organoid models of human and mouse ductal pancreatic cancer.. 160. 2014
Acetate is a bioenergetic substrate for human glioblastoma and brain metastases.. 159. 2014
Subnucleosomal structures and nucleosome asymmetry across a genome.. 159. 2014
iDISCO: a simple, rapid method to immunolabel large tissue samples for volume imaging.. 159. 2014
Integrated genomic characterization of papillary thyroid carcinoma.. 159. 2014
Discovery of a class of endogenous mammalian lipids with anti-diabetic and anti-inflammatory effects.. 159. 2014
Structural evolution of glycan recognition by a family of potent HIV antibodies.. 159. 2014
Identification of multipotent luminal progenitor cells in human prostate organoid cultures.. 159. 2014
Organoid cultures derived from patients with advanced prostate cancer.. 159. 2014
Altering the intestinal microbiota during a critical developmental window has lasting metabolic consequences.. 158. 2014
Broadly neutralizing antibodies and viral inducers decrease rebound from HIV-1 latent reservoirs in humanized mice.. 158. 2014
Control of the inheritance of regulatory T cell identity by a cis element in the Foxp3 locus.. 158. 2014
TLR signals induce phagosomal MHC-I delivery from the endosomal recycling compartment to allow cross-presentation.. 158. 2014
p53-dependent Nestin regulation links tumor suppression to cellular plasticity in liver cancer.. 158. 2014
Adipsin is an adipokine that improves β cell function in diabetes.. 158. 2014
IRF4 is a key thermogenic transcriptional partner of PGC-1α.. 158. 2014
Natural neural projection dynamics underlying social behavior.. 157. 2014
Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis.. 157. 2014
Broad-spectrum therapeutic suppression of metastatic melanoma through nuclear hormone receptor activation.. 156. 2014
Serpins promote cancer cell survival and vascular co-option in brain metastasis.. 156. 2014
Activity-driven local ATP synthesis is required for synaptic function.. 156. 2014
Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch.. 156. 2014
Leveraging cross-species transcription factor binding site patterns: from diabetes risk loci to disease mechanisms.. 156. 2014
Redox modification of nuclear actin by MICAL-2 regulates SRF signaling.. 156. 2014
Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor.. 155. 2013
Glucocorticoid receptor confers resistance to antiandrogens by bypassing androgen receptor blockade.. 155. 2013
The somatic genomic landscape of glioblastoma.. 155. 2013
Hira-dependent histone H3.3 deposition facilitates PRC2 recruitment at developmental loci in ES cells.. 155. 2013
The proliferation-quiescence decision is controlled by a bifurcation in CDK2 activity at mitotic exit.. 155. 2013
SWR-C and INO80 chromatin remodelers recognize nucleosome-free regions near +1 nucleosomes.. 154. 2013
Selection of bone metastasis seeds by mesenchymal signals in the primary tumor stroma.. 154. 2013
Structure-function analysis of STING activation by c[G(2',5')pA(3',5')p] and targeting by antiviral DMXAA.. 154. 2013
Regulation of axon guidance by compartmentalized nonsense-mediated mRNA decay.. 153. 2013
The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4.. 153. 2013
Punctuated evolution of prostate cancer genomes.. 153. 2013
Non-cell-autonomous tumor suppression by p53.. 153. 2013
Evolution and impact of subclonal mutations in chronic lymphocytic leukemia.. 152. 2013
Control of nutrient stress-induced metabolic reprogramming by PKCζ in tumorigenesis.. 152. 2013
A molecular roadmap of reprogramming somatic cells into iPS cells.. 151. 2012
Microcephaly gene links trithorax and REST/NRSF to control neural stem cell proliferation and differentiation.. 151. 2012
Promoter-specific transcription inhibition in Staphylococcus aureus by a phage protein.. 151. 2012
Convergent multi-miRNA targeting of ApoE drives LRP1/LRP8-dependent melanoma metastasis and angiogenesis.. 151. 2012
Activation of innate immunity is required for efficient nuclear reprogramming.. 151. 2012
Efficient direct reprogramming of mature amniotic cells into endothelial cells by ETS factors and TGFβ suppression.. 151. 2012
Pathogenic simian immunodeficiency virus infection is associated with expansion of the enteric virome.. 151. 2012
The endosomal sorting complex ESCRT-II mediates the assembly and architecture of ESCRT-III helices.. 151. 2012
Foxp3 exploits a pre-existent enhancer landscape for regulatory T cell lineage specification.. 151. 2012
A validated regulatory network for Th17 cell specification.. 151. 2012
Loss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma.. 150. 2012
Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing.. 150. 2012
The BMP inhibitor Coco reactivates breast cancer cells at lung metastatic sites.. 150. 2012
HSF1 drives a transcriptional program distinct from heat shock to support highly malignant human cancers.. 150. 2012
A CXCL1 paracrine network links cancer chemoresistance and metastasis.. 150. 2012
Extrathymic generation of regulatory T cells in placental mammals mitigates maternal-fetal conflict.. 150. 2012
Genome-wide nucleosome specificity and directionality of chromatin remodelers.. 149. 2012
Spatial positive feedback at the onset of mitosis.. 149. 2012
Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons.. 149. 2012
Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism.. 149. 2012
Mbd3/NURD complex regulates expression of 5-hydroxymethylcytosine marked genes in embryonic stem cells.. 147. 2011
The functional organization of cutaneous low-threshold mechanosensory neurons.. 147. 2011
Comprehensive genome-wide protein-DNA interactions detected at single-nucleotide resolution.. 147. 2011
Lin28A and Lin28B inhibit let-7 microRNA biogenesis by distinct mechanisms.. 147. 2011
TORC1 regulates endocytosis via Npr1-mediated phosphoinhibition of a ubiquitin ligase adaptor.. 147. 2011
Endothelial-derived angiocrine signals induce and sustain regenerative lung alveolarization.. 147. 2011
The Eph-receptor A7 is a soluble tumor suppressor for follicular lymphoma.. 147. 2011
Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13.. 147. 2011
A mechanism for tunable autoinhibition in the structure of a human Ca2+/calmodulin- dependent kinase II holoenzyme.. 146. 2011
FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autism.. 146. 2011
A rapid and scalable system for studying gene function in mice using conditional RNA interference.. 145. 2011
Osh proteins regulate phosphoinositide metabolism at ER-plasma membrane contact sites.. 144. 2011
IL-7 engages multiple mechanisms to overcome chronic viral infection and limit organ pathology.. 144. 2011
High-resolution genome-wide mapping of the primary structure of chromatin.. 144. 2011
Endophilin functions as a membrane-bending molecule and is delivered to endocytic zones by exocytosis.. 143. 2010
Function of miR-146a in controlling Treg cell-mediated regulation of Th1 responses.. 142. 2010
The monopolin complex crosslinks kinetochore components to regulate chromosome-microtubule attachments.. 142. 2010
Plzf regulates germline progenitor self-renewal by opposing mTORC1.. 142. 2010
Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism.. 142. 2010
LINE-1 activity in facultative heterochromatin formation during X chromosome inactivation.. 141. 2010
Distinct factors control histone variant H3.3 localization at specific genomic regions.. 140. 2010
Merlin/NF2 suppresses tumorigenesis by inhibiting the E3 ubiquitin ligase CRL4(DCAF1) in the nucleus.. 140. 2010
Tumor self-seeding by circulating cancer cells.. 139. 2009
PI3 kinase signals BCR-dependent mature B cell survival.. 139. 2009
Transposition into replicating DNA occurs through interaction with the processivity factor.. 138. 2009
Androgen receptor regulates a distinct transcription program in androgen-independent prostate cancer.. 138. 2009
Neuregulin1/ErbB4 signaling induces cardiomyocyte proliferation and repair of heart injury.. 138. 2009
CarD is an essential regulator of rRNA transcription required for Mycobacterium tuberculosis persistence.. 138. 2009
WNT/TCF signaling through LEF1 and HOXB9 mediates lung adenocarcinoma metastasis.. 138. 2009
Retinoblastoma has properties of a cone precursor tumor and depends upon cone-specific MDM2 signaling.. 137. 2009
Platelet matrix metalloprotease-1 mediates thrombogenesis by activating PAR1 at a cryptic ligand site.. 137. 2009
Functional reconstitution of ESCRT-III assembly and disassembly.. 136. 2009
A translational profiling approach for the molecular characterization of CNS cell types.. 135. 2008
Application of a translational profiling approach for the comparative analysis of CNS cell types.. 135. 2008
Arrestin-related ubiquitin-ligase adaptors regulate endocytosis and protein turnover at the cell surface.. 135. 2008
Transcription factor E2-2 is an essential and specific regulator of plasmacytoid dendritic cell development.. 135. 2008
Acetylated lysine 56 on histone H3 drives chromatin assembly after repair and signals for the completion of repair.. 134. 2008
Hox repertoires for motor neuron diversity and connectivity gated by a single accessory factor, FoxP1.. 134. 2008
Growth-inhibitory and tumor- suppressive functions of p53 depend on its repression of CD44 expression.. 134. 2008
Virus Infection Induces NF-kappaB-dependent interchromosomal associations mediating monoallelic IFN-beta gene expression.. 134. 2008
Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences.. 133. 2008
Systemic endocrine instigation of indolent tumor growth requires osteopontin.. 133. 2008
The microRNA miR-1 regulates a MEF-2-dependent retrograde signal at neuromuscular junctions.. 133. 2008
Identification of positionally distinct astrocyte subtypes whose identities are specified by a homeodomain code.. 133. 2008
CASK Functions as a Mg2+-independent neurexin kinase.. 133. 2008
SKAR links pre-mRNA splicing to mTOR/S6K1-mediated enhanced translation efficiency of spliced mRNAs.. 133. 2008
STIM2 is a feedback regulator that stabilizes basal cytosolic and endoplasmic reticulum Ca2+ levels.. 131. 2007
Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions.. 131. 2007
SARA-regulated vesicular targeting underlies formation of the light-sensing organelle in mammalian rods.. 130. 2007
Single-molecule studies reveal dynamics of DNA unwinding by the ring-shaped T7 helicase.. 129. 2007
A Rac-cGMP signaling pathway.. 128. 2007
FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis.. 128. 2007
Essential role for nuclear PTEN in maintaining chromosomal integrity.. 128. 2007
Ubiquitination regulates PTEN nuclear import and tumor suppression.. 128. 2007
Deletion of DDB1 in mouse brain and lens leads to p53-dependent elimination of proliferating cells.. 127. 2006
Structural basis for the histone chaperone activity of Asf1.. 127. 2006
Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration.. 127. 2006
Beta 4 integrin amplifies ErbB2 signaling to promote mammary tumorigenesis.. 126. 2006
A CK2-dependent mechanism for degradation of the PML tumor suppressor.. 126. 2006
Interchromosomal interactions and olfactory receptor choice.. 126. 2006
Comparative oncogenomics identifies NEDD9 as a melanoma metastasis gene.. 125. 2006
ESCRT-I core and ESCRT-II GLUE domain structures reveal role for GLUE in linking to ESCRT-I and membranes.. 125. 2006
Structural and functional organization of the ESCRT-I trafficking complex.. 125. 2006
Cryo-EM reconstruction of dengue virus in complex with the carbohydrate recognition domain of DC-SIGN.. 124. 2006
Structure of DDB1 in complex with a paramyxovirus V protein: viral hijack of a propeller cluster in ubiquitin ligase.. 124. 2006
mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events.. 123. 2005
Adam meets Eph: an ADAM substrate recognition module acts as a molecular switch for ephrin cleavage in trans.. 123. 2005
Common molecular pathways mediate long-term potentiation of synaptic excitation and slow synaptic inhibition.. 123. 2005
PAR1 is a matrix metalloprotease-1 receptor that promotes invasion and tumorigenesis of breast cancer cells.. 120. 2005
AID is required for c-myc/IgH chromosome translocations in vivo.. 118. 2004
The chromosomal passenger complex is required for chromatin-induced microtubule stabilization and spindle assembly.. 118. 2004
Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells.. 117. 2004
Identification and distinct regulation of yeast TATA box-containing genes.. 116. 2004
Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria.. 115. 2003
Taspase1: a threonine aspartase required for cleavage of MLL and proper HOX gene expression.. 115. 2003
Switch-of-function mutants based on morphology classification of Ras superfamily small GTPases.. 113. 2003
Structural basis for the autoinhibition of c-Abl tyrosine kinase.. 112. 2003
Conversion of proepithelin to epithelins: roles of SLPI and elastase in host defense and wound repair.. 111. 2002
Yph1p, an ORC-interacting protein: potential links between cell proliferation control, DNA replication, and ribosome biogenesis.. 109. 2002
Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand.. 109. 2002
Regulation of motor neuron pool sorting by differential expression of type II cadherins.. 109. 2002
The bHLH transcription factors OLIG2 and OLIG1 couple neuronal and glial subtype specification.. 109. 2002
Regulating axon branch stability: the role of p190 RhoGAP in repressing a retraction signaling pathway.. 107. 2001
An effective AIDS vaccine based on live attenuated vesicular stomatitis virus recombinants.. 106. 2001
Ubiquitin-dependent sorting into the multivesicular body pathway requires the function of a conserved endosomal protein sorting complex, ESCRT-I.. 106. 2001
Genetic ablation and restoration of the olfactory topographic map.. 103. 2000
Src tyrosine kinase is a novel direct effector of G proteins.. 102. 2000
Structural basis for relief of autoinhibition of the Dbl homology domain of proto-oncogene Vav by tyrosine phosphorylation.. 102. 2000
The Xenopus chromokinesin Xkid is essential for metaphase chromosome alignment and must be degraded to allow anaphase chromosome movement.. 102. 2000
Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb.. 100. 2000
Sequence-specific RNA binding by a Nova KH domain: implications for paraneoplastic disease and the fragile X syndrome.. 100. 2000
Phosphatidylinositol 4,5-bisphosphate functions as a second messenger that regulates cytoskeleton-plasma membrane adhesion.. 100. 2000
Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate.. 99. 1999
Regulation of hormone-induced histone hyperacetylation and gene activation via acetylation of an acetylase.. 98. 1999
The Wilms tumor suppressor WT1 encodes a transcriptional activator of amphiregulin.. 98. 1999
Nuclear trafficking of Cubitus interruptus in the transcriptional regulation of Hedgehog target gene expression.. 98. 1999
Stat3 as an oncogene.. 98. 1999
Rhodopsin's carboxy-terminal cytoplasmic tail acts as a membrane receptor for cytoplasmic dynein by binding to the dynein light chain Tctex-1.. 97. 1999
Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor.. 96. 1999
Fab1p PtdIns(3)P 5-kinase function essential for protein sorting in the multivesicular body.. 95. 1998
Protein kinase C as a molecular machine for decoding calcium and diacylglycerol signals.. 95. 1998
Sec6/8 complex is recruited to cell-cell contacts and specifies transport vesicle delivery to the basal-lateral membrane in epithelial cells.. 93. 1998
Doublecortin, a brain-specific gene mutated in human X-linked lissencephaly and double cortex syndrome, encodes a putative signaling protein.. 92. 1998
Complex polymorphisms in an approximately 330 kDa protein are linked to chloroquine-resistant P. falciparum in Southeast Asia and Africa.. 91. 1997
The AP-3 adaptor complex is essential for cargo-selective transport to the yeast vacuole.. 91. 1997
Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300.. 90. 1997
TRAP is necessary for gliding motility and infectivity of plasmodium sporozoites.. 90. 1997
Calcium-induced restructuring of nuclear envelope and endoplasmic reticulum calcium stores.. 89. 1997
Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylase.. 89. 1997
Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agent.. 89. 1997
Kinase suppressor of Ras is ceramide-activated protein kinase.. 89. 1997
Secretory leukocyte protease inhibitor: a macrophage product induced by and antagonistic to bacterial lipopolysaccharide.. 88. 1997
p62(dok): a constitutively tyrosine-phosphorylated, GAP-associated protein in chronic myelogenous leukemia progenitor cells.. 88. 1997
The product of par-4, a gene induced during apoptosis, interacts selectively with the atypical isoforms of protein kinase C.. 86. 1996
Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection.. 86. 1996
The signal-dependent coactivator CBP is a nuclear target for pp90RSK.. 86. 1996
Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis.. 86. 1996
The 70 kDa S6 kinase complexes with and is activated by the Rho family G proteins Cdc42 and Rac1.. 85. 1996
Ceramide synthase mediates daunorubicin-induced apoptosis: an alternative mechanism for generating death signals.. 82. 1995
Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase.. 81. 1995
Autosomal dominant and recessive osteochondrodysplasias associated with the COL11A2 locus.. 80. 1995
Coatomer is essential for retrieval of dilysine-tagged proteins to the endoplasmic reticulum.. 79. 1994
The sorting receptor for yeast vacuolar carboxypeptidase Y is encoded by the VPS10 gene.. 77. 1994
The nuclear tyrosine kinase c-Abl negatively regulates cell growth.. 77. 1994
Nef induces CD4 endocytosis: requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain.. 76. 1994
Tyrosine kinase-dependent suppression of a potassium channel by the G protein-coupled m1 muscarinic acetylcholine receptor.. 75. 1993
A receptor for subgroup A Rous sarcoma virus is related to the low density lipoprotein receptor.. 74. 1993
Protein kinase C zeta isoform is critical for mitogenic signal transduction.. 74. 1993
The TATA-binding protein and associated factors are components of pol III transcription factor TFIIIB.. 71. 1992
Dominant negative MYC blocks transformation by ABL oncogenes.. 70. 1992
Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases.. 69. 1992
Nucleosomes, DNA-binding proteins, and DNA sequence modulate retroviral integration target site selection.. 69. 1992
Structurally distinct and stage-specific adenylyl cyclase genes play different roles in Dictyostelium development.. 69. 1992
ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK.. 68. 1992
The Drosophila learning and memory gene rutabaga encodes a Ca2+/Calmodulin-responsive adenylyl cyclase.. 68. 1992
In vivo transfer of the human cystic fibrosis transmembrane conductance regulator gene to the airway epithelium.. 68. 1992
The orientation and spacing of core DNA-binding motifs dictate selective transcriptional responses to three nuclear receptors.. 65. 1991
A novel protein kinase homolog essential for protein sorting to the yeast lysosome-like vacuole.. 64. 1991
The hematopoietic growth factor KL is encoded by the Sl locus and is the ligand of the c-kit receptor, the gene product of the W locus.. 63. 1990
Isolation and characterization of the Drosophila gene encoding the TATA box binding protein, TFIID.. 61. 1990
Mechanism of transcriptional activation by Sp1: evidence for coactivators.. 61. 1990
Phospholipase C-mediated hydrolysis of phosphatidylcholine is an important step in PDGF-stimulated DNA synthesis.. 61. 1990
Viral activation of the coagulation cascade: molecular interactions at the surface of infected endothelial cells.. 61. 1990
Positive and negative regulation of gene transcription by a retinoic acid-thyroid hormone receptor heterodimer.. 59. 1989
The erythroid-specific transcription factor Eryf1: a new finger protein.. 58. 1989
Mitosis-specific phosphorylation of p60c-src by p34cdc2-associated protein kinase.. 57. 1989
Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice.. 55. 1988
Signals for ribosomal frameshifting in the Rous sarcoma virus gag-pol region.. 55. 1988
cAMP-independent control of sporulation, glycogen metabolism, and heat shock resistance in S. cerevisiae.. 53. 1988
Discontinuous transcription or RNA processing of vaccinia virus late messengers results in a 5' poly(A) leader.. 50. 1987
Epstein-Barr virus gp350/220 binding to the B lymphocyte C3d receptor mediates adsorption, capping, and endocytosis.. 50. 1987
Expression of the proto-oncogene int-1 is restricted to postmeiotic male germ cells and the neural tube of mid-gestational embryos.. 50. 1987
Correct integration of retroviral DNA in vitro.. 49. 1987
Distinct sequence determinants direct intracellular sorting and modification of a yeast vacuolar protease.. 48. 1987
The S. cerevisiae CDC25 gene product regulates the RAS/adenylate cyclase pathway.. 48. 1987
A retrovirus vector expressing the putative mammary oncogene int-1 causes partial transformation of a mammary epithelial cell line.. 46. 1986
Homologous pairing of DNA molecules by Ustilago rec1 protein is promoted by sequences of Z-DNA.. 44. 1986
Mapping the major transcripts of ground squirrel hepatitis virus: the presumptive template for reverse transcriptase is terminally redundant.. 42. 1985
Transcription termination within the E1A gene of adenovirus induced by insertion of the mouse beta-major globin terminator element.. 40. 1985
Left-handed DNA and the synaptic pairing reaction promoted by Ustilago rec1 protein.. 40. 1985
Biogenesis of epithelial cell polarity: intracellular sorting and vectorial exocytosis of an apical plasma membrane glycoprotein.. 39. 1984
Hormonal regulation of the Rous sarcoma virus src gene via a heterologous promoter defines a threshold dose for cellular transformation.. 38. 1984
Segregation of transferrin to a mildly acidic (pH 6.5) para-Golgi compartment in the recycling pathway.. 37. 1984
Nuclear-cytoplasmic transport and VAI RNA-independent translation of influenza viral messenger RNAs in late adenovirus-infected cells.. 37. 1984
Expression of v-src and chicken c-src in rat cells demonstrates qualitative differences between pp60v-src and pp60c-src.. 37. 1984
Synapsis promoted by Ustilago rec1 protein.. 36. 1984
Topological linkage of circular DNA molecules promoted by Ustilago rec 1 protein and topoisomerase.. 34. 1983
Heteroduplex formation and polarity during strand transfer promoted by Ustilago rec 1 protein.. 33. 1983
Location and function of retroviral and SV40 sequences that enhance biochemical transformation after microinjection of DNA.. 33. 1983
Frameshift and intragenic suppressor mutations in a Rous sarcoma provirus suggest src encodes two proteins.. 32. 1983
A previously unidentified gene in the spc operon of Escherichia coli K12 specifies a component of the protein export machinery.. 31. 1982
Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome.. 31. 1982
Homologous pairing of DNA molecules promoted by a protein from Ustilago.. 29. 1982
Changes in amino-terminal sequences of pp60src lead to decreased membrane association and decreased in vivo tumorigenicity.. 28. 1982
Rapid acidification of endocytic vesicles containing alpha 2-macroglobulin.. 28. 1982
Transcription and accurate polyadenylation in vitro of RNA from the major late adenovirus 2 transcription unit.. 28. 1982
Infectivity and methylation of retroviral genomes is correlated with expression in the animal.. 26. 1981
Retroviruses as mutagens: insertion and excision of a nontransforming provirus alter expression of a resident transforming provirus.. 25. 1981
Molecular cloning and characterization of the chicken gene homologous to the transforming gene of Rous sarcoma virus.. 24. 1981
Analysis of avian leukosis virus DNA and RNA in bursal tumours: viral gene expression is not required for maintenance of the tumor state.. 23. 1981
Suppressor mutations that restore export of a protein with a defective signal sequence.. 23. 1981
Polarized distribution of viral envelope proteins in the plasma membrane of infected epithelial cells.. 20. 1980
Transformation by subgenomic fragments of Rous sarcoma virus DNA.. 19. 1980
The addition of 5' cap structures occurs early in hnRNA synthesis and prematurely terminated molecules are capped.. 19. 1980
Heterogeneity of genetic loci in chickens: analysis of endogenous viral and nonviral genes by cleavage of DNA with restriction endonucleases.. 18. 1979
Transformation of NIH/3T3 mouse cells by DNA of Rous sarcoma virus.. 17. 1979
Integration of the DNA of mouse mammary tumor virus in virus-infected normal and neoplastic tissue of the mouse.. 16. 1979
Mapping unintegrated avian sarcoma virus DNA: termini of linear DNA bear 300 nucleotides present once or twice in two species of circular DNA.. 15. 1978
Proviruses of avian sarcoma virus are terminally redundant, co-extensive with unintegrated linear DNA and integrated at many sites.. 15. 1978
Evidence that the transforming gene of avian sarcoma virus encodes a protein kinase associated with a phosphoprotein.. 15. 1978
At least 104 nucleotides are transposed from the 5' terminus of the avian sarcoma virus genome to the 5' termini of smaller viral mRNAs.. 15. 1978
Collection of insulin, EGF and alpha2-macroglobulin in the same patches on the surface of cultured fibroblasts and common internalization.. 14. 1978
Deoxyguanosine toxicity in a mouse T lymphoma: relationship to purine nucleoside phosphorylase-associated immune dysfunction.. 14. 1978
Deoxyadenosine metabolism and cytotoxicity in cultured mouse T lymphoma cells: a model for immunodeficiency disease.. 14. 1978
Inhomogeneous distribution of egg RNA sequences in the early embryo.. 14. 1978
Characteristics of cellular RNA related to the transforming gene of avian sarcoma viruses.. 13. 1978
Uninfected avian cells contain RNA related to the transforming gene of avian sarcoma viruses.. 13. 1978
A joint produce of the genes gag and pol of avian sarcoma virus: a possible precursor of reverse transcriptase.. 12. 1977
The size and genetic composition of virus-specific RNAs in the cytoplasm of cells producing avian sarcoma-leukosis viruses.. 12. 1977
Accumulation of alpha- and beta-globin messenger RNAs in mouse erythroleukemia cells.. 12. 1977
Cellular functions are required for the synthesis and integration of avian sarcoma virus-specific DNA.. 11. 1977
Chicken macrochromosomes contain an endogenous provirus and microchromosomes contain sequences related to the transforming gene of ASV.. 10. 1977
Infection of cultured rat hepatoma cells by mouse mammary tumor virus.. 10. 1977
Mouse mammary tumor virus DNA in infected rat cells: characterization of unintegrated forms.. 10. 1977
Dexamethasone-mediated induction of mouse mammary tumor virus RNA: a system for studying glucocorticoid action.. 6. 1975
A Prize for Cancer Prevention.. 171. 2017
TOR, the Gateway to Cellular Metabolism, Cell Growth, and Disease.. 171. 2017
PD-1 Blockers.. 162. 2015
Immunotherapy: The path to win the war on cancer?. 161. 2015
Behind the movement.. 150. 2012
SnapShot: Reactive Oxygen Intermediates (ROI).. 140. 2010
SnapShot: the ESCRT machinery.. 137. 2009
A new nomenclature for int-1 and related genes: the Wnt gene family.. 64. 1991
A ciliary synapse for "short-circuit" neuromodulation. 2022
Is iNOS beginning to smoke? 2011
FOXP3 and NFAT: partners in tolerance. 2006
Two birds with one stone--dealing with nuclear transport and spindle assembly. 2005
Evidence in favor of the essentiality of human cell membrane-bound ACE2 and against soluble ACE2 for SARS-CoV-2 infectivity. 2022
LINE-1 Activity in Facultative Heterochromatin Formation during X Chromosome Inactivation.. 166. 2016
Fundamental Biological Features of Spaceflight: Advancing the Field to Enable Deep-Space Exploration. 2020
Effects of COVID-19 on the Nervous System. 2020
Autophagy-Independent Functions of the Autophagy Machinery. 2019
Innate Lymphoid Cells: 10 Years On. 2018
Beyond Host Defense: Emerging Functions of the Immune System in Regulating Complex Tissue Physiology. 2018
Tumorigenic and Immunosuppressive Effects of Endoplasmic Reticulum Stress in Cancer. 2017
p62 in Cancer: Signaling Adaptor Beyond Autophagy. 2016
Metabolic Control of Longevity. 2016
Germinal center selection and the antibody response to influenza. 2015
Immune regulation of metabolic homeostasis in health and disease. 2015
Metabolic control of autophagy. 2014
Discovering the power of single molecules. 2014
Feedback on fat: p62-mTORC1-autophagy connections. 2011
Nonresolving inflammation. 2010
Chaperoning histones during DNA replication and repair. 2010
Microbial pathogenesis of Mycobacterium tuberculosis: dawn of a discipline. 2001
The "dark side" of chromatin remodeling: repressive effects on transcription. 1999
Metalloprotease-disintegrins: links to cell adhesion and cleavage of TNF alpha and Notch. 1997
Wnt genes. 1992
Leukemia and the disruption of normal hematopoiesis. 1991
Cachexia: A systemic consequence of progressive, unresolved disease. 2023
Metastasis. 2023
Metabolic analysis as a driver for discovery, diagnosis, and therapy. 2022
Inflammatory adaptation in barrier tissues. 2021
Targeting KRAS(G12C): From Inhibitory Mechanism to Modulation of Antitumor Effects in Patients. 2020
The Psychiatric Cell Map Initiative: A Convergent Systems Biological Approach to Illuminating Key Molecular Pathways in Neuropsychiatric Disorders. 2018
The PI3K Pathway in Human Disease. 2017
Hallmarks of Tissue-Resident Lymphocytes. 2016
Improving Cancer Treatment via Mathematical Modeling: Surmounting the Challenges Is Worth the Effort. 2015
Th17 and regulatory T cells in mediating and restraining inflammation. 2010
Translocation and reversible localization of signaling proteins: a dynamic future for signal transduction. 2000
Neural science: a century of progress and the mysteries that remain. 2000
Nitric oxide synthases: roles, tolls, and controls. 1994
Cell signaling by second messenger waves. 1991

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