p62 in Cancer: Signaling Adaptor Beyond Autophagy. Review uri icon

Overview

abstract

  • Adaptor proteins participate in selective autophagy, which is critical for cellular detoxification and stress relief. However, new evidence supports an autophagy-independent key role of the adaptor p62 (encoded by the gene Sqstm1) in signaling functions central to tumor initiation in the epithelium and suppression of tumor progression in the stroma.

publication date

  • October 20, 2016

Research

keywords

  • Autophagy
  • Carcinogenesis
  • Neoplasms
  • Sequestosome-1 Protein
  • Tumor Microenvironment

Identity

PubMed Central ID

  • PMC5114003

Scopus Document Identifier

  • 84992363256

Digital Object Identifier (DOI)

  • 10.1016/j.cell.2016.09.030

PubMed ID

  • 27768885

Additional Document Info

volume

  • 167

issue

  • 3