Detecting Associations between Major Depressive Disorder Treatment and Essential Hypertension using Electronic Health Records. Academic Article uri icon



  • In this observational study, we investigate the correlation between depression and hypertension on a cohort of patients treated for major depressive disorder using Selective Serotonin Reuptake Inhibitors (SSRIs) and assess the effect of depression treatment on the diagnoses and treatment for essential hypertension. Our results indicate that the positive effect of successful depression treatment can be discovered and estimated from electronic health record (EHR) data even for a small sample size. We have also successfully detected differences in the effect of depression treatment in hypertensive patients between the two phenotypes representing successful treatment outcomes-response and remission- concluding that achieving remission has a longer lasting effect than response.


  • Pathak, Jyotishman
  • Simon, Gyorgy
  • Li, Dingcheng
  • Biernacka, Joanna M
  • Jenkins, Gregory J
  • Chute, Christopher G
  • Hall-Flavin, Daniel K
  • Weinshilboum, Richard M

publication date

  • April 7, 2014


PubMed Central ID

  • PMC4419773

PubMed ID

  • 25954583

Additional Document Info


  • 2014