Novel Approaches to Imaging Tumor Metabolism. Review uri icon

Overview

abstract

  • The field of metabolism research has made a dramatic resurgence in recent years, fueled by a newfound appreciation of the interactions between metabolites and phenotype. Metabolic substrates and their products can be biomarkers of a wide range of pathologies, including cancer, but our understanding of their in vivo interactions and pathways has been hindered by the robustness of noninvasive imaging approaches. The past 3 decades have been flushed with the development of new techniques for the study of metabolism in vivo. These methods include nuclear-based, predominantly positron emission tomography and magnetic resonance imaging, many of which have been translated to the clinic. The purpose of this review was to introduce both long-standing imaging strategies as well as novel approaches to the study of perturbed metabolic pathways in the setting of carcinogenesis. This will involve descriptions of nuclear probes labeled with C and F as well C for study using hyperpolarized magnetic resonance imaging. Highlighting both advantages and disadvantages of each approach, the aim of this summary was to provide the reader with a framework for interrogation of metabolic aberrations in their system of interest.

publication date

  • May 1, 2015

Research

keywords

  • Biomarkers, Tumor
  • Magnetic Resonance Imaging
  • Neoplasms
  • Positron-Emission Tomography

Identity

PubMed Central ID

  • PMC4460609

Scopus Document Identifier

  • 84930588099

Digital Object Identifier (DOI)

  • 10.1097/PPO.0000000000000111

PubMed ID

  • 26049695

Additional Document Info

volume

  • 21

issue

  • 3