Keshari, Kayvan Rahimi

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selected publications

Hyperpolarized Nano-NMR Platform for Quantification of Mass Limited Samples. Analytical chemistry. 2024 Academic Article GET IT
Imaging Tumor Metabolism. Cold Spring Harbor perspectives in medicine. 2024 Academic Article GET IT
Multi-parametric atlas of the pre-metastatic liver for prediction of metastatic outcome in early-stage pancreatic cancer. Nature medicine. 2024 Academic Article GET IT
Times cited: 4
Imaging brain glucose metabolism in vivo reveals propionate as a major anaplerotic substrate in pyruvate dehydrogenase deficiency. Cell metabolism. 2024 Academic Article GET IT
Assessment of the Feasibility of Hyperpolarized [1-¹³ C]pyruvate Whole-Abdomen MRI using D₂ O Solvation in Humans. Journal of magnetic resonance imaging : JMRI. 2024 Letter GET IT
Task Activation Results in Regional ¹³ C-Lactate Signal Increase in the Human Brain. 2024 GET IT
Evidence of ¹³ C-lactate oxidation in the human brain from hyperpolarized ¹³ C-MRI. Magnetic resonance in medicine. 2024 Academic Article GET IT
First in-human evaluation of [1-¹³ C]pyruvate in D₂ O for hyperpolarized MRI of the brain: A safety and feasibility study. Magnetic resonance in medicine. 2024 Academic Article GET IT
New Horizons in Hyperpolarized ¹³C MRI. Molecular imaging and biology. 2024 Academic Article GET IT
Early life high fructose exposure disrupts microglia function and impedes neurodevelopment. 2023 GET IT
[6,6'-² H₂ ] fructose as a deuterium metabolic imaging probe in liver cancer. NMR in biomedicine. 2023 Academic Article GET IT
MRI of transmembrane water efflux in gliomas. Nature biomedical engineering. 2023 Comment GET IT
Series of first-order phase shifts correct lattice reduction of fractional K-space indices. Journal of magnetic resonance (San Diego, Calif. : 1997). 2023 Academic Article GET IT
Metabolic adaptation supports enhanced macrophage efferocytosis in limited-oxygen environments. Cell metabolism. 2022 Academic Article GET IT
Times cited: 27
Micro-Slab Coil Design for Hyperpolarized Metabolic Flux Analysis in Multiple Samples. Bioengineering (Basel, Switzerland). 2022 Academic Article GET IT
Revealing de novo pyrimidine synthesis as a key vulnerability in brain tumors. Cancer cell. 2022 Comment GET IT
Improved total sensitivity estimation for multiple receive coils in MRI using ratios of first-order statistics. Magma (New York, N.Y.). 2022 Academic Article GET IT
Metabolic analysis as a driver for discovery, diagnosis, and therapy. Cell. 2022 Review GET IT
Times cited: 72
"Free super-resolution MRI by BRICKD slices". Journal of magnetic resonance (San Diego, Calif. : 1997). 2022 Academic Article GET IT
Times cited: 1
Hyperpolarized [5-¹³C,4,4-²H₂,5-¹⁵N]-L-glutamine provides a means of annotating in vivo metabolic utilization of glutamine. Proceedings of the National Academy of Sciences of the United States of America. 2022 Academic Article GET IT
Times cited: 12
Ketohexokinase-mediated fructose metabolism is lost in hepatocellular carcinoma and can be leveraged for metabolic imaging. Science advances. 2022 Academic Article GET IT
Hyperpolarized Micro-NMR Platform for Sensitive Analysis of In Vitro Metabolic Flux in Living Cells. Methods in molecular biology (Clifton, N.J.). 2022 Academic Article GET IT
Hyaluronic acid fuels pancreatic cancer cell growth. eLife. 2021 Academic Article GET IT
Times cited: 52
The metabolic adaptation evoked by arginine enhances the effect of radiation in brain metastases. Science advances. 2021 Academic Article GET IT
Deuterium Metabolic Imaging of Pancreatic Cancer. NMR in biomedicine. 2021 Editorial Article GET IT
Times cited: 4
Imaging Early Response to Checkpoint Inhibition. Cancer research. 2021 Comment GET IT
Immunometabolism of Tissue-Resident Macrophages - An Appraisal of the Current Knowledge and Cutting-Edge Methods and Technologies. Frontiers in immunology. 2021 Review GET IT
Times cited: 13
Editorial commentary for the special issue: technological developments in hyperpolarized ¹³C imaging-toward a deeper understanding of tumor metabolism in vivo. Magma (New York, N.Y.). 2021 Editorial Article GET IT
Times cited: 2
High Fructose Drives the Serine Synthesis Pathway in Acute Myeloid Leukemic Cells. Cell metabolism. 2020 Academic Article GET IT
Times cited: 41
Multi-sample measurement of hyperpolarized pyruvate-to-lactate flux in melanoma cells. NMR in biomedicine. 2020 Academic Article GET IT
Times cited: 9
Dynamic volumetric hyperpolarized ¹³ C imaging with multi-echo EPI. Magnetic resonance in medicine. 2020 Academic Article GET IT
Times cited: 3
Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition. Cancer discovery. 2020 Academic Article GET IT
Times cited: 151
Elevated Tumor Lactate and Efflux in High-grade Prostate Cancer demonstrated by Hyperpolarized ¹³C Magnetic Resonance Spectroscopy of Prostate Tissue Slice Cultures. Cancers. 2020 Academic Article GET IT
Times cited: 16
Hyperpolarized MRI of Human Prostate Cancer Reveals Increased Lactate with Tumor Grade Driven by Monocarboxylate Transporter 1. Cell metabolism. 2019 Academic Article GET IT
Times cited: 100
Hyperpolarized [6-¹³C,¹⁵N₃]-Arginine as a Probe for in Vivo Arginase Activity. ACS chemical biology. 2019 Academic Article GET IT
Times cited: 15
The Role of Lactate Metabolism in Prostate Cancer Progression and Metastases Revealed by Dual-Agent Hyperpolarized ¹³C MRSI. Cancers. 2019 Academic Article GET IT
Times cited: 40
Hyperpolarized ¹³C MRI: Path to Clinical Translation in Oncology. Neoplasia (New York, N.Y.). 2018 Review GET IT
Times cited: 307
Hyperpolarized MRI Visualizes Warburg Effects and Predicts Treatment Response to mTOR Inhibitors in Patient-Derived ccRCC Xenograft Models. Cancer research. 2018 Academic Article GET IT
Times cited: 27
A non-synthetic approach to extending the lifetime of hyperpolarized molecules using D₂O solvation. Journal of magnetic resonance (San Diego, Calif. : 1997). 2018 Academic Article GET IT
Times cited: 12
Imaging glutathione depletion in the rat brain using ascorbate-derived hyperpolarized MR and PET probes. Scientific reports. 2018 Academic Article GET IT
Times cited: 13
Metabolic Imaging of the Human Brain with Hyperpolarized ¹³C Pyruvate Demonstrates ¹³C Lactate Production in Brain Tumor Patients. Cancer research. 2018 Academic Article GET IT
Times cited: 178
Targeted AKT Inhibition in Prostate Cancer Cells and Spheroids Reduces Aerobic Glycolysis and Generation of Hyperpolarized [1-¹³C] Lactate. Molecular cancer research : MCR. 2018 Academic Article GET IT
Times cited: 19
In Vivo Imaging of Glutamine Metabolism to the Oncometabolite 2-Hydroxyglutarate in IDH1/2 Mutant Tumors. Cell metabolism. 2017 Academic Article GET IT
Times cited: 78
Cancer Metabolism and Tumor Heterogeneity: Imaging Perspectives Using MR Imaging and Spectroscopy. Contrast media & molecular imaging. 2017 Review GET IT
Times cited: 32
Real-time quantitative analysis of metabolic flux in live cells using a hyperpolarized micromagnetic resonance spectrometer. Science advances. 2017 Academic Article GET IT
Times cited: 50
Hyperpolarized ¹³C Spectroscopic Evaluation of Oxidative Stress in a Rodent Model of Steatohepatitis. Scientific reports. 2017 Academic Article GET IT
Times cited: 16
Multinuclear NMR and MRI Reveal an Early Metabolic Response to mTOR Inhibition in Sarcoma. Cancer research. 2017 Academic Article GET IT
Times cited: 17
Biomarker-Based PET Imaging of Diffuse Intrinsic Pontine Glioma in Mouse Models. Cancer research. 2017 Academic Article GET IT
Times cited: 26
Hyperpolarized ¹³C pyruvate mouse brain metabolism with absorptive-mode EPSI at 1T. Journal of magnetic resonance (San Diego, Calif. : 1997). 2016 Academic Article GET IT
Times cited: 12
High-Throughput Indirect Quantitation of ¹³C Enriched Metabolites Using ¹H NMR. Analytical chemistry. 2016 Academic Article GET IT
Times cited: 15
Sampling Hyperpolarized Molecules Utilizing a 1 Tesla Permanent Magnetic Field. Scientific reports. 2016 Academic Article GET IT
Times cited: 17
Separation of extra- and intracellular metabolites using hyperpolarized (13)C diffusion weighted MR. Journal of magnetic resonance (San Diego, Calif. : 1997). 2016 Academic Article GET IT
Times cited: 19
Remodeling the Vascular Microenvironment of Glioblastoma with α-Particles. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2016 Academic Article GET IT
Times cited: 25
Non-invasive PET Imaging of PARP1 Expression in Glioblastoma Models. Molecular imaging and biology. 2016 Academic Article GET IT
Times cited: 71
Non-invasive differentiation of benign renal tumors from clear cell renal cell carcinomas using clinically translatable hyperpolarized ¹³C pyruvate magnetic resonance. Tomography (Ann Arbor, Mich.). 2016 Academic Article GET IT
Times cited: 11
Hyperpolarization MRI: Preclinical Models and Potential Applications in Neuroradiology. Topics in magnetic resonance imaging : TMRI. 2016 Information Resource GET IT
Times cited: 22
The Potential of Metabolic Imaging. Seminars in nuclear medicine. 2016 Information Resource GET IT
Times cited: 29
Caged [(18)F]FDG Glycosylamines for Imaging Acidic Tumor Microenvironments Using Positron Emission Tomography. Bioconjugate chemistry. 2015 Academic Article GET IT
Times cited: 34
(13)C-labeled biochemical probes for the study of cancer metabolism with dynamic nuclear polarization-enhanced magnetic resonance imaging. Cancer & metabolism. 2015 Academic Article GET IT
Times cited: 240
Real-time measurement of hyperpolarized lactate production and efflux as a biomarker of tumor aggressiveness in an MR compatible 3D cell culture bioreactor. NMR in biomedicine. 2015 Academic Article GET IT
Times cited: 43
Metabolic response of prostate cancer to nicotinamide phophoribosyltransferase inhibition in a hyperpolarized MR/PET compatible bioreactor. The Prostate. 2015 Academic Article GET IT
Times cited: 29
Novel Approaches to Imaging Tumor Metabolism. Cancer journal (Sudbury, Mass.). 2015 Information Resource GET IT
Times cited: 25
A boronate-caged [¹⁸F]FLT probe for hydrogen peroxide detection using positron emission tomography. Journal of the American Chemical Society. 2014 Academic Article GET IT
Times cited: 109
Rapid in vivo apparent diffusion coefficient mapping of hyperpolarized (13) C metabolites. Magnetic resonance in medicine. 2014 Academic Article GET IT
Times cited: 26
Noninvasive in vivo imaging of diabetes-induced renal oxidative stress and response to therapy using hyperpolarized 13C dehydroascorbate magnetic resonance. Diabetes. 2014 Academic Article GET IT
Times cited: 59
OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin. Proceedings of the National Academy of Sciences of the United States of America. 2014 Academic Article GET IT
Times cited: 183
Chemistry and biochemistry of 13C hyperpolarized magnetic resonance using dynamic nuclear polarization. Chemical Society reviews. 2013 Information Resource GET IT
Times cited: 295
Case report: glioblastoma multiforme complicating familial cavernous malformations. Clinical neuroradiology. 2013 Letter GET IT
Times cited: 7
Hyperpolarized [1-13C]dehydroascorbate MR spectroscopy in a murine model of prostate cancer: comparison with 18F-FDG PET. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2013 Academic Article GET IT
Times cited: 50
Metabolic reprogramming and validation of hyperpolarized 13C lactate as a prostate cancer biomarker using a human prostate tissue slice culture bioreactor. The Prostate. 2013 Academic Article GET IT
Times cited: 89
Diffusion MR of hyperpolarized 13C molecules in solution. The Analyst. 2013 Academic Article GET IT
Times cited: 31
Hyperpolarized 13C-pyruvate magnetic resonance reveals rapid lactate export in metastatic renal cell carcinomas. Cancer research. 2012 Academic Article GET IT
Times cited: 89
Effect of oxygen concentration on viability and metabolism in a fluidized-bed bioartificial liver using ³¹P and ¹³C NMR spectroscopy. Tissue engineering. Part C, Methods. 2012 Academic Article GET IT
Times cited: 9
Generating contrast in hyperpolarized 13C MRI using ligand-receptor interactions. The Analyst. 2012 Academic Article GET IT
Times cited: 18
Hyperpolarized 13C dehydroascorbate as an endogenous redox sensor for in vivo metabolic imaging. Proceedings of the National Academy of Sciences of the United States of America. 2011 Academic Article GET IT
Times cited: 128
In vivo measurement of normal rat intracellular pyruvate and lactate levels after injection of hyperpolarized [1-(13)C]alanine. Magnetic resonance imaging. 2011 Academic Article GET IT
Times cited: 34
Correlation of phospholipid metabolites with prostate cancer pathologic grade, proliferative status and surgical stage - impact of tissue environment. NMR in biomedicine. 2011 Academic Article GET IT
Times cited: 50
A hydrogen peroxide-responsive hyperpolarized 13C MRI contrast agent. Journal of the American Chemical Society. 2011 Academic Article GET IT
Times cited: 98
Imaging of blood flow using hyperpolarized [(13)C]urea in preclinical cancer models. Journal of magnetic resonance imaging : JMRI. 2011 Academic Article GET IT
Times cited: 94
Multi-compound polarization by DNP allows simultaneous assessment of multiple enzymatic activities in vivo. Journal of magnetic resonance (San Diego, Calif. : 1997). 2010 Academic Article GET IT
Times cited: 149
Metabolic assessment of a novel chronic myelogenous leukemic cell line and an imatinib resistant subline by H NMR spectroscopy. Metabolomics : Official journal of the Metabolomic Society. 2010 Academic Article GET IT
Hyperpolarized (13)C spectroscopy and an NMR-compatible bioreactor system for the investigation of real-time cellular metabolism. Magnetic resonance in medicine. 2010 Academic Article GET IT
Times cited: 64
Metabolic, pathologic, and genetic analysis of prostate tissues: quantitative evaluation of histopathologic and mRNA integrity after HR-MAS spectroscopy. NMR in biomedicine. 2009 Academic Article GET IT
Times cited: 30
Hyperpolarized [2-13C]-fructose: a hemiketal DNP substrate for in vivo metabolic imaging. Journal of the American Chemical Society. 2009 Academic Article GET IT
Times cited: 103
Generation of hyperpolarized substrates by secondary labeling with [1,1-13C] acetic anhydride. Proceedings of the National Academy of Sciences of the United States of America. 2009 Academic Article GET IT
Times cited: 47
Evaluation of the ERETIC method as an improved quantitative reference for 1H HR-MAS spectroscopy of prostate tissue. Magnetic resonance in medicine. 2009 Academic Article GET IT
Times cited: 62
(1)H HR-MAS spectroscopy for quantitative measurement of choline concentration in amniotic fluid as a marker of fetal lung maturity: inter- and intraobserver reproducibility study. Journal of magnetic resonance imaging : JMRI. 2008 Academic Article GET IT
Times cited: 19
Evaluation of lactate and alanine as metabolic biomarkers of prostate cancer using 1H HR-MAS spectroscopy of biopsy tissues. Magnetic resonance in medicine. 2008 Academic Article GET IT
Times cited: 175
Quantification of choline- and ethanolamine-containing metabolites in human prostate tissues using 1H HR-MAS total correlation spectroscopy. Magnetic resonance in medicine. 2008 Academic Article GET IT
Times cited: 106
Lactic acid and proteoglycans as metabolic markers for discogenic back pain. Spine. 2008 Academic Article GET IT
Times cited: 40
Quantitative analysis of prostate metabolites using 1H HR-MAS spectroscopy. Magnetic resonance in medicine. 2006 Academic Article GET IT
Times cited: 211
Correlation of HR-MAS spectroscopy derived metabolite concentrations with collagen and proteoglycan levels and Thompson grade in the degenerative disc. Spine. 2005 Academic Article GET IT
Times cited: 32
Fourier Transform Infrared Imaging of focal lesions in human osteoarthritic cartilage. European cells & materials. 2005 Academic Article GET IT
Times cited: 52
Characterization of intervertebral disc degeneration by high-resolution magic angle spinning (HR-MAS) spectroscopy. Magnetic resonance in medicine. 2005 Academic Article GET IT
Times cited: 41

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Background

education and training

Ph.D., University of North Carolina 2009
B.A., University of California, Berkeley 2003

Contact

full name

Kayvan Rahimi Keshari

VIVO Weill Cornell Medical College

Kayvan Rahimi Keshari Professor of Biomedical Engineering in Radiology

Publications

selected publications

Background

education and training

Contact

full name

primary email