Hyperpolarized MRI of Human Prostate Cancer Reveals Increased Lactate with Tumor Grade Driven by Monocarboxylate Transporter 1. Academic Article uri icon

Overview

abstract

  • Metabolic imaging using hyperpolarized magnetic resonance can increase the sensitivity of MRI, though its ability to inform on relevant changes to biochemistry in humans remains unclear. In this work, we image pyruvate metabolism in patients, assessing the reproducibility of delivery and conversion in the setting of primary prostate cancer. We show that the time to max of pyruvate does not vary significantly within patients undergoing two separate injections or across patients. Furthermore, we show that lactate increases with Gleason grade. RNA sequencing data demonstrate a significant increase in the predominant pyruvate uptake transporter, monocarboxylate transporter 1. Increased protein expression was also observed in regions of high lactate signal, implicating it as the driver of lactate signal in vivo. Targeted DNA sequencing for actionable mutations revealed the highest lactate occurred in patients with PTEN loss. This work identifies a potential link between actionable genomic alterations and metabolic information derived from hyperpolarized pyruvate MRI.

publication date

  • September 26, 2019

Research

keywords

  • Lactic Acid
  • Magnetic Resonance Imaging
  • Monocarboxylic Acid Transporters
  • Prostatic Neoplasms
  • Pyruvic Acid
  • Symporters

Identity

PubMed Central ID

  • PMC6949382

Scopus Document Identifier

  • 85077761700

Digital Object Identifier (DOI)

  • 10.1016/j.cmet.2019.08.024

PubMed ID

  • 31564440

Additional Document Info

volume

  • 31

issue

  • 1