Antiangiogenic Therapies and Extracranial Metastasis in Glioblastoma: A Case Report and Review of the Literature. Academic Article uri icon

Overview

abstract

  • We present a case report of a patient with glioblastoma multiforme (GBM) complicated by extracranial metastasis (ECM) whose survival of nearly four years surpassed the anticipated life expectancy given numerous negative prognostic factors including EGFRvIII-mutation, unmethylated MGMT promoter status, and ECM. Interestingly, while this patient suffered from locally aggressive disease with multiple intracranial recurrences, the proximal cause of death was progressive extracranial disease and complications related to pulmonary metastases. Herein, we review potential mechanisms of ECM with an emphasis upon glioblastoma molecular and genetic profiles and the potential implications of targeted agents such as bevacizumab.

publication date

  • June 23, 2015

Identity

PubMed Central ID

  • PMC4493308

Scopus Document Identifier

  • 33644758237

Digital Object Identifier (DOI)

  • 10.1038/sj.jid.5700005

PubMed ID

  • 26199775

Additional Document Info

volume

  • 2015