Medical treatment of male infertility. Review uri icon

Overview

abstract

  • The majority of male infertility is idiopathic. However, there are multiple known causes of male infertility, and some of these causes can be treated medically with high success rates. In cases of idiopathic or genetic causes of male infertility, medical management is typically empirical; in most instances medical therapy represents off-label use that is not specifically approved by the FDA. Understanding the hypothalamic-pituitary-gonadal (HPG) axis and the effect of estrogen excess is critical for the assessment and treatment of male infertility. The use of certain medical treatment has been associated with an increase in sperm production or motility, and primarily focuses on optimizing testosterone (T) production from the Leydig cells, increasing follicle-stimulating hormone (FSH) levels to stimulate Sertoli cells and spermatogenesis, and normalizing the T to estrogen ratio.

publication date

  • March 1, 2014

Identity

PubMed Central ID

  • PMC4708300

Scopus Document Identifier

  • 84901238177

Digital Object Identifier (DOI)

  • 10.3978/j.issn.2223-4683.2014.01.06

PubMed ID

  • 26816749

Additional Document Info

volume

  • 3

issue

  • 1