State-of-the-art of regulatory dendritic cells in cancer. Review uri icon

Overview

abstract

  • Dendritic cells (DCs) with robust immunosuppressive activity are commonly found in the microenvironment of advanced solid tumors. These innate immune cells are generically termed regulatory DCs and include various subsets such as plasmacytoid, conventional and monocyte-derived/inflammatory populations whose normal function is subverted by tumor-derived signals. This review summarizes recent findings on the nature and function of regulatory DCs, their relationship with other myeloid subsets and unique therapeutic opportunities to abrogate malignant progression through their targeting.

publication date

  • April 23, 2016

Research

keywords

  • Dendritic Cells
  • Neoplasms

Identity

PubMed Central ID

  • PMC4942379

Scopus Document Identifier

  • 84975775438

Digital Object Identifier (DOI)

  • 10.1016/j.pharmthera.2016.04.003

PubMed ID

  • 27118338

Additional Document Info

volume

  • 164