Juan R Cubillos-Ruiz   Associate Professor of Microbiology and Immunology in Obstetrics and Gynecology

Our research seeks to understand the molecular and metabolic programs that dictate immune cell function in health and disease. We are interested in defining how molecular pathways that sense organelle stress direct the immune system in cancer, inflammation, autoimmunity, and infectious diseases. We are also developing new forms of immunotherapy for aggressive malignancies like ovarian cancer. Learn more about our research here: https://www.cubillosruizlab.org/
  • Cellular Stress
  • Immunometabolism
  • Immunotherapy
  • Tumor Immunology

Publications

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selected publications

  • CCL5-mediated endogenous antitumor immunity elicited by adoptively transferred lymphocytes and dendritic cell depletion.  Cancer research.  2009 Academic Article GET IT
    Times cited: 52

Research

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Funding awarded

  • Immunometabolic Programs Controlled by ER Stress in Cancer  awarded by National Cancer Institute Principal Investigator 2023 - 2028
  • Safeguarding T cell cytoskeletal integrity for improved cancer immunotherapy  awarded by American Cancer Society Principal Investigator 2025 - 2026
  • A sUPR driver of T cell metabolic dysfunction in ovarian cancer  awarded by United States Department of Defense Principal Investigator 2023 - 2026
  • missing activity Principal Investigator 2021 - 2024
  • missing activity Principal Investigator 2021 - 2024
  • ER stress-driven IRE1a-XBP1 signaling in lung cancer  awarded by National Cancer Institute Co-Principal Investigator 2023 - 2028
  • missing activity Key Personnel 2022 - 2024
  • missing activity Key Personnel 2021 - 2024
  • Regulation of T cell immune response in Heart Failure with Preserved Ejection Fraction  awarded by National Heart, Lung, & Blood Institute Principal Investigator Subaward 2023 - 2027
  • Endoplasmic Reticulum Stress Responses in Pain  awarded by National Institute on Aging Principal Investigator Subaward 2020 - 2025

Background

Contact

full name

  • Juan R Cubillos-Ruiz

primary email

  • jur2016@med.cornell.edu

External Relationships

externalRelationships

  • Relationships and collaborations with for-profit and not-for-profit organizations are of vital importance to our faculty because these exchanges of scientific information foster innovation. As experts in their fields, WCM physicians and scientists are sought after by many organizations to consult and educate. WCM and its faculty make this information available to the public, thus creating a transparent environment.

    Ownership refers to any financial stake an individual owns in any company (e.g., stock options, equity interest)Ownership:
    Autoimmunity Biologic Solutions, Inc.