Dynamics of pulse wave velocity and vascular augmentation index in association with endothelial progenitor cells in SLE. Academic Article uri icon

Overview

abstract

  • Patients with SLE display a significantly higher cardiovascular risk (CVR). Pulse wave velocity (PWV) has meanwhile been established as a reliable parameter of end-organ damage. Endothelial progenitor cells (EPCs) are critically involved in vascular repair under both physiological and pathological conditions. The aim of the study was to analyse PWV and the Vascular Augmentation Index (VAI) and EPC numbers/regeneration in a well-defined German SLE cohort. Thirty patients were included. Only two individuals displayed a PWV of above 10 m/s. There was no correlation between PWV percentiles and disease activity as reflected by the SLE Disease Activity Index. Neither EPC colonies nor percentages of circulating EPCs (CD133+/KDR+) correlated with PWV/VAI in a positive or negative manner. Thus, it can be questioned whether pulse wave analysis and/or EPC proliferation and circulating cell numbers are truly useful for CVR assessment in SLE.

publication date

  • December 23, 2016

Identity

PubMed Central ID

  • PMC5237712

Scopus Document Identifier

  • 85055728035

Digital Object Identifier (DOI)

  • 10.1136/lupus-2016-000185

PubMed ID

  • 28176918

Additional Document Info

volume

  • 3

issue

  • 1