Niewold, Timothy

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selected publications

Regional european genetic ancestry predicts type I interferon level and risk of severe viral infection. QJM : monthly journal of the Association of Physicians. 2024 Academic Article GET IT
Genetically transitional disease: conceptual understanding and applicability to rheumatic disease. Nature reviews. Rheumatology. 2024 Review GET IT
Times cited: 1
Association of endometriosis with Sjögren's syndrome: Genetic insights (Review). International journal of molecular medicine. 2024 Review GET IT
Advances in the management of systemic lupus erythematosus. BMJ (Clinical research ed.). 2023 Review GET IT
Times cited: 1
Type I Interferons in Autoimmunity: Implications in Clinical Phenotypes and Treatment Response. The Journal of rheumatology. 2023 Review GET IT
Relationship of systemic type I interferon activity with clinical phenotypes, disease activity, and damage accrual in systemic lupus erythematosus in treatment-naive patients: a retrospective longitudinal analysis. Arthritis research & therapy. 2023 Academic Article GET IT
Times cited: 12
Autoantibody repertoire characterization provides insight into the pathogenesis of monogenic and polygenic autoimmune diseases. Frontiers in immunology. 2023 Academic Article GET IT
Times cited: 3
APOL1 variant-expressing endothelial cells exhibit autophagic dysfunction and mitochondrial stress. Frontiers in genetics. 2022 Academic Article GET IT
Times cited: 9
Interleukin (IL) 16: a candidate urinary biomarker for proliferative lupus nephritis. Lupus science & medicine. 2022 Academic Article GET IT
Times cited: 11
Is Rheumatoid Arthritis a Causal Factor in Cardiovascular Disease?. Arthritis & rheumatology (Hoboken, N.J.). 2022 Editorial Article GET IT
Axonal dysfunction is associated with interferon-γ levels in childhood-onset systemic lupus erythematosus: a multivoxel magnetic resonance spectroscopy study. Rheumatology (Oxford, England). 2022 Academic Article GET IT
Times cited: 3
Artificial intelligence and deep learning to map immune cell types in inflamed human tissue. Journal of immunological methods. 2022 Academic Article GET IT
Times cited: 3
Interferon pathway lupus risk alleles modulate risk of death from acute COVID-19. Translational research : the journal of laboratory and clinical medicine. 2022 Academic Article GET IT
Times cited: 13
Type I Interferons in Autoimmunity. The Journal of investigative dermatology. 2022 Review GET IT
Times cited: 32
Single-cell expression quantitative trait loci (eQTL) analysis of SLE-risk loci in lupus patient monocytes. Arthritis research & therapy. 2021 Academic Article GET IT
Times cited: 9
High Systemic Type I Interferon Activity Is Associated With Active Class III/IV Lupus Nephritis. The Journal of rheumatology. 2021 Academic Article GET IT
Times cited: 18
Risk of Toxicity After Initiating Immune Checkpoint Inhibitor Treatment in Patients With Rheumatoid Arthritis. Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases. 2021 Academic Article GET IT
Times cited: 23
Progressive Cellular Senescence Mediates Renal Dysfunction in Ischemic Nephropathy. Journal of the American Society of Nephrology : JASN. 2021 Academic Article GET IT
Times cited: 53
T Cells in Systemic Lupus Erythematosus. Rheumatic diseases clinics of North America. 2021 Review GET IT
Times cited: 8
Proteome study of cutaneous lupus erythematosus (CLE) and dermatomyositis skin lesions reveals IL-16 is differentially upregulated in CLE. Arthritis research & therapy. 2021 Academic Article GET IT
Times cited: 13
Clinical disease activity and flare in SLE: Current concepts and novel biomarkers. Journal of autoimmunity. 2021 Review GET IT
Times cited: 43
COVID-19 in patients with systemic lupus erythematosus: lessons learned from the inflammatory disease. Translational research : the journal of laboratory and clinical medicine. 2020 Review GET IT
Times cited: 74
Type I interferon in the pathogenesis of systemic lupus erythematosus. Current opinion in immunology. 2020 Review GET IT
Times cited: 131
Type I interferon antagonists in clinical development for lupus. Expert opinion on investigational drugs. 2020 Review GET IT
Times cited: 18
Novel mutation in the NRLP3 manifesting as an intermediate phenotype of cryopyrinopathies. Rheumatology international. 2020 Review GET IT
Times cited: 4
Distinct Single Cell Gene Expression in Peripheral Blood Monocytes Correlates With Tumor Necrosis Factor Inhibitor Treatment Response Groups Defined by Type I Interferon in Rheumatoid Arthritis. Frontiers in immunology. 2020 Academic Article GET IT
Times cited: 12
Familial Aggregation of Childhood- and Adulthood-Onset Systemic Lupus Erythematosus. Arthritis care & research. 2020 Academic Article GET IT
Times cited: 10
Type I interferon. Cytokine. 2020 Editorial Article GET IT
TLR7 and TLR8 Differentially Activate the IRF and NF-κB Pathways in Specific Cell Types to Promote Inflammation. ImmunoHorizons. 2020 Academic Article GET IT
Times cited: 58
A Clinically and Biologically Based Subclassification of the Idiopathic Inflammatory Myopathies Using Machine Learning. ACR open rheumatology. 2020 Academic Article GET IT
Times cited: 15
Lessons from precision medicine in rheumatology. Multiple sclerosis (Houndmills, Basingstoke, England). 2020 Review GET IT
Times cited: 11
Distinct Effector B Cells Induced by Unregulated Toll-like Receptor 7 Contribute to Pathogenic Responses in Systemic Lupus Erythematosus. 2020 GET IT
Times cited: 11
A Successful Trial for Lupus - How Good Is Good Enough?. The New England journal of medicine. 2019 Editorial Article GET IT
Times cited: 14
Type I Interferon Predicts an Alternate Immune System Phenotype in Systemic Lupus Erythematosus. ACR open rheumatology. 2019 Academic Article GET IT
Times cited: 10
High levels of circulating interferons type I, type II and type III associate with distinct clinical features of active systemic lupus erythematosus. Arthritis research & therapy. 2019 Academic Article GET IT
Times cited: 141
Interferon Chemokine Score and Other Cytokine Measures Track With Changes in Disease Activity in Patients With Juvenile and Adult Dermatomyositis. ACR open rheumatology. 2019 Academic Article GET IT
Times cited: 10
When pregnancy tames the wolf. The Journal of experimental medicine. 2019 Comment GET IT
Times cited: 2
Novel genetic associations with interferon in systemic lupus erythematosus identified by replication and fine-mapping of trait-stratified genome-wide screen. Cytokine. 2019 Academic Article GET IT
Times cited: 19
MUC5B Promoter Variant and Rheumatoid Arthritis with Interstitial Lung Disease. The New England journal of medicine. 2018 Academic Article GET IT
Times cited: 336
Pathogenic Citrulline-Multispecific B Cell Receptor Clades in Rheumatoid Arthritis. Arthritis & rheumatology (Hoboken, N.J.). 2018 Academic Article GET IT
Times cited: 64
Distinct Effector B Cells Induced by Unregulated Toll-like Receptor 7 Contribute to Pathogenic Responses in Systemic Lupus Erythematosus. Immunity. 2018 Academic Article GET IT
Times cited: 581
A plausibly causal functional lupus-associated risk variant in the STAT1-STAT4 locus. Human molecular genetics. 2018 Academic Article GET IT
Times cited: 28
The genetics and molecular pathogenesis of systemic lupus erythematosus (SLE) in populations of different ancestry. Gene. 2018 Review GET IT
Times cited: 85
Type I interferon in rheumatic diseases. Nature reviews. Rheumatology. 2018 Review GET IT
Times cited: 215
Associations between type I interferon and antiphospholipid antibody status differ between ancestral backgrounds. Lupus science & medicine. 2018 Academic Article GET IT
Times cited: 9
Increased Whole Blood Viscosity Is Associated with the Presence of Digital Ulcers in Systemic Sclerosis: Results from a Cross-Sectional Pilot Study. Autoimmune diseases. 2017 Academic Article GET IT
Times cited: 9
Predictors of changes in disease activity among children with juvenile dermatomyositis enrolled in the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Legacy Registry. Clinical rheumatology. 2017 Academic Article GET IT
Times cited: 4
Lupus-Associated Functional Polymorphism in PNP Causes Cell Cycle Abnormalities and Interferon Pathway Activation in Human Immune Cells. Arthritis & rheumatology (Hoboken, N.J.). 2017 Academic Article GET IT
Times cited: 21
Brief Report: A Novel ELANE Mutation Associated With Inflammatory Arthritis, Defective NETosis, and Recurrent Parvovirus Infection. 2017 GET IT
Times cited: 14
By CyTOF: Heterogeneity of Human Monocytes. Arteriosclerosis, thrombosis, and vascular biology. 2017 Editorial Article GET IT
Times cited: 4
Transancestral mapping and genetic load in systemic lupus erythematosus. Nature communications. 2017 Academic Article GET IT
Times cited: 286
Single-cell gene expression patterns in lupus monocytes independently indicate disease activity, interferon and therapy. Lupus science & medicine. 2017 Academic Article GET IT
Times cited: 21
Spotlight on blisibimod and its potential in the treatment of systemic lupus erythematosus: evidence to date. Drug design, development and therapy. 2017 Review GET IT
Times cited: 28
CD11b activation suppresses TLR-dependent inflammation and autoimmunity in systemic lupus erythematosus. The Journal of clinical investigation. 2017 Academic Article GET IT
Times cited: 93
Discerning Risk of Disease Transition in Relatives of Systemic Lupus Erythematosus Patients Utilizing Soluble Mediators and Clinical Features. Arthritis & rheumatology (Hoboken, N.J.). 2017 Academic Article GET IT
Times cited: 53
Association of IRF5 polymorphisms with increased risk for systemic lupus erythematosus in population of Crete, a southern-eastern European Greek island. Gene. 2017 Academic Article GET IT
Times cited: 10
Defining biological subsets in systemic lupus erythematosus: progress toward personalized therapy. Pharmaceutical medicine. 2017 Academic Article GET IT
Times cited: 13
Dynamics of pulse wave velocity and vascular augmentation index in association with endothelial progenitor cells in SLE. Lupus science & medicine. 2016 Academic Article GET IT
Times cited: 4
Differential Expression of miR-4520a Associated With Pyrin Mutations in Familial Mediterranean Fever (FMF). Journal of cellular physiology. 2016 Academic Article GET IT
Times cited: 23
Gene Expression Profiling in Blood and Affected Muscle Tissues Reveals Differential Activation Pathways in Patients with New-onset Juvenile and Adult Dermatomyositis. The Journal of rheumatology. 2016 Academic Article GET IT
Times cited: 24
Genetics of human lupus nephritis. Clinical immunology (Orlando, Fla.). 2016 Review GET IT
Times cited: 51
Manifestations of systemic lupus erythematosus in female patients with polysomy X: Possible roles of chromosome X. 2016 GET IT
Times cited: 4
Incidence of systemic lupus erythematosus in a population-based cohort using revised 1997 American College of Rheumatology and the 2012 Systemic Lupus International Collaborating Clinics classification criteria. Lupus. 2016 Academic Article GET IT
Times cited: 30
Combined role of vitamin D status and CYP24A1 in the transition to systemic lupus erythematosus. Annals of the rheumatic diseases. 2016 Academic Article GET IT
Times cited: 41
Connective tissue diseases: Targeting type I interferon in systemic lupus erythematosus. Nature reviews. Rheumatology. 2016 Comment GET IT
Times cited: 13
Elevated procalcitonin levels in a severe lupus flare without infection. Lupus. 2016 Letter GET IT
Times cited: 7
Drugs in early clinical development for Systemic Lupus Erythematosus. Expert opinion on investigational drugs. 2016 Review GET IT
Times cited: 11
Genetic data: The new challenge of personalized medicine, insights for rheumatoid arthritis patients. Gene. 2016 Review GET IT
Times cited: 33
Altered type II interferon precedes autoantibody accrual and elevated type I interferon activity prior to systemic lupus erythematosus classification. Annals of the rheumatic diseases. 2016 Academic Article GET IT
Times cited: 196
Decreased SMG7 expression associates with lupus-risk variants and elevated antinuclear antibody production. Annals of the rheumatic diseases. 2016 Academic Article GET IT
Times cited: 14
Folate metabolic pathway single nucleotide polymorphisms: a predictive pharmacogenetic marker of methotrexate response in Indian (Asian) patients with rheumatoid arthritis. Pharmacogenomics. 2015 Academic Article GET IT
Times cited: 51
Increased pretreatment serum IFN-β/α ratio predicts non-response to tumour necrosis factor α inhibition in rheumatoid arthritis. Annals of the rheumatic diseases. 2015 Academic Article GET IT
Times cited: 42
Immunological biomarkers in dermatomyositis. Current rheumatology reports. 2015 Review GET IT
Times cited: 12
The type I interferons: Basic concepts and clinical relevance in immune-mediated inflammatory diseases. Gene. 2015 Review GET IT
Times cited: 86
Genetic associations of leptin-related polymorphisms with systemic lupus erythematosus. Clinical immunology (Orlando, Fla.). 2015 Academic Article GET IT
Times cited: 9
Advances in lupus genetics. Current opinion in rheumatology. 2015 Review GET IT
Times cited: 46
Immunogenetics of systemic lupus erythematosus: A comprehensive review. Journal of autoimmunity. 2015 Review GET IT
Times cited: 186
Widely divergent transcriptional patterns between SLE patients of different ancestral backgrounds in sorted immune cell populations. Journal of autoimmunity. 2015 Academic Article GET IT
Times cited: 47
Ribosomal and immune transcripts associate with relapse in acquired ADAMTS13-deficient thrombotic thrombocytopenic purpura. PloS one. 2015 Academic Article GET IT
Times cited: 3
The Thr300Ala variant in ATG16L1 is associated with improved survival in human colorectal cancer and enhanced production of type I interferon. Gut. 2015 Academic Article GET IT
Times cited: 70
Genetic association of CD247 (CD3ζ) with SLE in a large-scale multiethnic study. Genes and immunity. 2015 Academic Article GET IT
Times cited: 25
Dysregulation of antiviral helicase pathways in systemic lupus erythematosus. Frontiers in genetics. 2014 Review GET IT
Times cited: 21
Genetic analysis of the pathogenic molecular sub-phenotype interferon-alpha identifies multiple novel loci involved in systemic lupus erythematosus. Genes and immunity. 2014 Academic Article GET IT
Times cited: 56
Interferon regulatory factors: critical mediators of human lupus. Translational research : the journal of laboratory and clinical medicine. 2014 Review GET IT
Times cited: 34
The IRF5-TNPO3 association with systemic lupus erythematosus has two components that other autoimmune disorders variably share. Human molecular genetics. 2014 Academic Article GET IT
Times cited: 66
Sirukumab : a novel therapy for lupus nephritis?. Expert opinion on investigational drugs. 2014 Review GET IT
Times cited: 18
Preferential association of a functional variant in complement receptor 2 with antibodies to double-stranded DNA. Annals of the rheumatic diseases. 2014 Academic Article GET IT
Times cited: 8
Autoimmune disease genetics 2013. Journal of immunology research. 2014 Editorial Article GET IT
Times cited: 2
Type I interferon in human autoimmunity. Frontiers in immunology. 2014 Academic Article GET IT
Times cited: 22
Serum free light chains, interferon-alpha, and interleukins in systemic lupus erythematosus. Lupus. 2014 Academic Article GET IT
Times cited: 24
Efficacy Results of a 52-week Trial of Adalimumab in the Treatment of Refractory Sarcoidosis. Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG. 2014 Academic Article GET IT
Times cited: 89
Two functional lupus-associated BLK promoter variants control cell-type- and developmental-stage-specific transcription. American journal of human genetics. 2014 Academic Article GET IT
Times cited: 52
Combined protein- and nucleic acid-level effects of rs1143679 (R77H), a lupus-predisposing variant within ITGAM. Human molecular genetics. 2014 Academic Article GET IT
Times cited: 25
End-stage renal disease in African Americans with lupus nephritis is associated with APOL1. Arthritis & rheumatology (Hoboken, N.J.). 2014 Academic Article GET IT
Times cited: 236
Genetics of the type I interferon pathway in systemic lupus erythematosus. International journal of clinical rheumatology. 2013 Academic Article GET IT
Times cited: 54
Preferential binding to Elk-1 by SLE-associated IL10 risk allele upregulates IL10 expression. PLoS genetics. 2013 Academic Article GET IT
Times cited: 37
Nucleic Acid sensors and type I interferon production in systemic lupus erythematosus. Frontiers in immunology. 2013 Review GET IT
Times cited: 80
Activation of the Interferon Pathway is Dependent Upon Autoantibodies in African-American SLE Patients, but Not in European-American SLE Patients. Frontiers in immunology. 2013 Academic Article GET IT
Times cited: 51
Familial aggregation of high tumor necrosis factor alpha levels in systemic lupus erythematosus. Clinical & developmental immunology. 2013 Academic Article GET IT
Times cited: 12
Successful treatment of a mycophenolate mofetil-refractory proliferative lupus nephritis with Belimumab in a 19-year-old woman. 2013 GET IT
Times cited: 17
Interferon-α induction and detection of anti-ro, anti-la, anti-sm, and anti-rnp autoantibodies by autoantigen microarray analysis in juvenile dermatomyositis. Arthritis and rheumatism. 2013 Academic Article GET IT
Times cited: 35
ABIN1 dysfunction as a genetic basis for lupus nephritis. Journal of the American Society of Nephrology : JASN. 2013 Academic Article GET IT
Times cited: 70
Genetic variation near IRF8 is associated with serologic and cytokine profiles in systemic lupus erythematosus and multiple sclerosis. Genes and immunity. 2013 Review GET IT
Times cited: 46
Increased serum type I interferon activity in organ-specific autoimmune disorders: clinical, imaging, and serological associations. Frontiers in immunology. 2013 Academic Article GET IT
Times cited: 17
PTPN22 association in systemic lupus erythematosus (SLE) with respect to individual ancestry and clinical sub-phenotypes. PloS one. 2013 Academic Article GET IT
Times cited: 54
Trans-ancestral studies fine map the SLE-susceptibility locus TNFSF4. PLoS genetics. 2013 Academic Article GET IT
Times cited: 45
Variable association of reactive intermediate genes with systemic lupus erythematosus in populations with different African ancestry. The Journal of rheumatology. 2013 Academic Article GET IT
Times cited: 13
MicroRNA-3148 modulates allelic expression of toll-like receptor 7 variant associated with systemic lupus erythematosus. PLoS genetics. 2013 Academic Article GET IT
Times cited: 103
Admixture mapping in lupus identifies multiple functional variants within IFIH1 associated with apoptosis, inflammation, and autoantibody production. PLoS genetics. 2013 Academic Article GET IT
Times cited: 98
Circulating cytokines in sarcoidosis: phenotype-specific alterations for fibrotic and non-fibrotic pulmonary disease. Cytokine. 2013 Academic Article GET IT
Times cited: 32
Plasma levels of osteopontin identify patients at risk for organ damage in systemic lupus erythematosus. Arthritis research & therapy. 2013 Academic Article GET IT
Times cited: 36
Autoimmune disease genetics. Clinical & developmental immunology. 2012 Editorial Article GET IT
Times cited: 1
Association of two independent functional risk haplotypes in TNIP1 with systemic lupus erythematosus. Arthritis and rheumatism. 2012 Academic Article GET IT
Times cited: 72
Impact of genetic ancestry and sociodemographic status on the clinical expression of systemic lupus erythematosus in American Indian-European populations. Arthritis and rheumatism. 2012 Academic Article GET IT
Times cited: 65
Interferon regulatory factor 5 in the pathogenesis of systemic lupus erythematosus. Clinical & developmental immunology. 2012 Review GET IT
Times cited: 44
Implication of VEGFR2 in systemic lupus erythematosus: a combined genetic and structural biological approach. Clinical and experimental rheumatology. 2012 Academic Article GET IT
Times cited: 12
Brief Report: IRF5 systemic lupus erythematosus risk haplotype is associated with asymptomatic serologic autoimmunity and progression to clinical autoimmunity in mothers of children with neonatal lupus. Arthritis and rheumatism. 2012 Academic Article GET IT
Times cited: 35
Inhibition of interferon-beta responses in multiple sclerosis immune cells associated with high-dose statins. Archives of neurology. 2012 Academic Article GET IT
Times cited: 29
Large-scale analysis of tumor necrosis factor α levels in systemic lupus erythematosus. Arthritis and rheumatism. 2012 Academic Article GET IT
Times cited: 73
Fine mapping of Xq28: both MECP2 and IRAK1 contribute to risk for systemic lupus erythematosus in multiple ancestral groups. Annals of the rheumatic diseases. 2012 Academic Article GET IT
Times cited: 99
Functional genetic polymorphisms in ILT3 are associated with decreased surface expression on dendritic cells and increased serum cytokines in lupus patients. Annals of the rheumatic diseases. 2012 Academic Article GET IT
Times cited: 28
Gene-expression-guided selection of candidate loci and molecular phenotype analyses enhance genetic discovery in systemic lupus erythematosus. Clinical & developmental immunology. 2012 Academic Article GET IT
Times cited: 12
Variation in the ICAM1-ICAM4-ICAM5 locus is associated with systemic lupus erythematosus susceptibility in multiple ancestries. Annals of the rheumatic diseases. 2012 Review GET IT
Times cited: 57
Genetic ancestry, serum interferon-α activity, and autoantibodies in systemic lupus erythematosus. The Journal of rheumatology. 2012 Academic Article GET IT
Times cited: 30
The clinical and immunologic features of pulmonary fibrosis in sarcoidosis. Translational research : the journal of laboratory and clinical medicine. 2012 Academic Article GET IT
Times cited: 48
A functional haplotype of UBE2L3 confers risk for systemic lupus erythematosus. Genes and immunity. 2012 Academic Article GET IT
Times cited: 53
Identification of IRF8, TMEM39A, and IKZF3-ZPBP2 as susceptibility loci for systemic lupus erythematosus in a large-scale multiracial replication study. American journal of human genetics. 2012 Academic Article GET IT
Times cited: 154
Evidence for gene-gene epistatic interactions among susceptibility loci for systemic lupus erythematosus. Arthritis and rheumatism. 2012 Academic Article GET IT
Times cited: 53
Evaluation of TRAF6 in a large multiancestral lupus cohort. Arthritis and rheumatism. 2012 Academic Article GET IT
Times cited: 51
Cytokines in systemic lupus erythematosus 2011. Journal of biomedicine & biotechnology. 2011 Editorial Article GET IT
Times cited: 4
Role of MYH9 and APOL1 in African and non-African populations with lupus nephritis. Genes and immunity. 2011 Academic Article GET IT
Times cited: 55
Linkage of type I interferon activity and TNF-alpha levels in serum with sarcoidosis manifestations and ancestry. PloS one. 2011 Academic Article GET IT
Times cited: 23
B lymphocyte stimulator levels in systemic lupus erythematosus: higher circulating levels in African American patients and increased production after influenza vaccination in patients with low baseline levels. Arthritis and rheumatism. 2011 Academic Article GET IT
Times cited: 58
Analysis of autosomal genes reveals gene-sex interactions and higher total genetic risk in men with systemic lupus erythematosus. Annals of the rheumatic diseases. 2011 Academic Article GET IT
Times cited: 81
IRF5 haplotypes demonstrate diverse serological associations which predict serum interferon alpha activity and explain the majority of the genetic association with systemic lupus erythematosus. Annals of the rheumatic diseases. 2011 Academic Article GET IT
Times cited: 130
Identification of novel genetic susceptibility loci in African American lupus patients in a candidate gene association study. Arthritis and rheumatism. 2011 Academic Article GET IT
Times cited: 100
The autoimmune disease risk allele of UBE2L3 in African American patients with systemic lupus erythematosus: a recessive effect upon subphenotypes. The Journal of rheumatology. 2011 Academic Article GET IT
Times cited: 24
Type I interferon signature is high in lupus and neuromyelitis optica but low in multiple sclerosis. Journal of the neurological sciences. 2011 Academic Article GET IT
Times cited: 63
Osteopontin alleles are associated with clinical characteristics in systemic lupus erythematosus. Journal of biomedicine & biotechnology. 2011 Academic Article GET IT
Times cited: 30
Interferon alpha as a primary pathogenic factor in human lupus. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. 2011 Review GET IT
Times cited: 129
Association of PPP2CA polymorphisms with systemic lupus erythematosus susceptibility in multiple ethnic groups. Arthritis and rheumatism. 2011 Academic Article GET IT
Times cited: 36
Influenza vaccination responses in human systemic lupus erythematosus: impact of clinical and demographic features. Arthritis and rheumatism. 2011 Academic Article GET IT
Times cited: 64
Phenotypic associations of genetic susceptibility loci in systemic lupus erythematosus. Annals of the rheumatic diseases. 2011 Academic Article GET IT
Times cited: 104
Autoimmune disease risk variant of IFIH1 is associated with increased sensitivity to IFN-α and serologic autoimmunity in lupus patients. Journal of immunology (Baltimore, Md. : 1950). 2011 Academic Article GET IT
Times cited: 131
Bone health issues in sarcoidosis. Current rheumatology reports. 2011 Review GET IT
Times cited: 52
Association of genetic variants in complement factor H and factor H-related genes with systemic lupus erythematosus susceptibility. PLoS genetics. 2011 Academic Article GET IT
Times cited: 179
Vitamin D deficiency is associated with an increased autoimmune response in healthy individuals and in patients with systemic lupus erythematosus. Annals of the rheumatic diseases. 2011 Academic Article GET IT
Times cited: 196
Familial aggregation of autoimmune disease in juvenile dermatomyositis. Pediatrics. 2011 Academic Article GET IT
Times cited: 54
Association of the PTPN22 R620W polymorphism with increased risk for SLE in the genetically homogeneous population of Crete. Lupus. 2011 Academic Article GET IT
Times cited: 40
Network analysis of associations between serum interferon-α activity, autoantibodies, and clinical features in systemic lupus erythematosus. Arthritis and rheumatism. 2011 Academic Article GET IT
Times cited: 216
Cytokines in systemic lupus erythematosus. Journal of biomedicine & biotechnology. 2011 Editorial Article GET IT
Times cited: 1
Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus. Nature genetics. 2011 Academic Article GET IT
Times cited: 228
Interferon regulatory factors in human lupus pathogenesis. Translational research : the journal of laboratory and clinical medicine. 2011 Review GET IT
Times cited: 87
The unexplained female predominance of systemic lupus erythematosus: clues from genetic and cytokine studies. Clinical reviews in allergy & immunology. 2011 Review GET IT
Times cited: 185
Evaluation of the TREX1 gene in a large multi-ancestral lupus cohort. Genes and immunity. 2011 Academic Article GET IT
Times cited: 229
A loss-of-function variant of the antiviral molecule MAVS is associated with a subset of systemic lupus patients. EMBO molecular medicine. 2011 Academic Article GET IT
Times cited: 91
Identification of a systemic lupus erythematosus susceptibility locus at 11p13 between PDHX and CD44 in a multiethnic study. American journal of human genetics. 2010 Academic Article GET IT
Times cited: 73
Drug-induced granulomatous interstitial nephritis in a patient with ankylosing spondylitis during therapy with adalimumab. 2010 GET IT
Times cited: 41
Gene-gene-sex interaction in cytokine gene polymorphisms revealed by serum interferon alpha phenotype in juvenile dermatomyositis. The Journal of pediatrics. 2010 Academic Article GET IT
Times cited: 33
Lesional and nonlesional skin from patients with untreated juvenile dermatomyositis displays increased numbers of mast cells and mature plasmacytoid dendritic cells. Arthritis and rheumatism. 2010 Academic Article GET IT
Times cited: 56
Rheumatologic manifestations of sarcoidosis. Seminars in respiratory and critical care medicine. 2010 Review GET IT
Times cited: 82
Trait-stratified genome-wide association study identifies novel and diverse genetic associations with serologic and cytokine phenotypes in systemic lupus erythematosus. Arthritis research & therapy. 2010 Academic Article GET IT
Times cited: 90
The role of genetic variation near interferon-kappa in systemic lupus erythematosus. Journal of biomedicine & biotechnology. 2010 Academic Article GET IT
Times cited: 48
Promoter variant of PIK3C3 is associated with autoimmunity against Ro and Sm epitopes in African-American lupus patients. Journal of biomedicine & biotechnology. 2010 Academic Article GET IT
Times cited: 24
Interferon alpha in systemic lupus erythematosus. Journal of biomedicine & biotechnology. 2010 Review GET IT
Times cited: 98
African-derived genetic polymorphisms in TNFAIP3 mediate risk for autoimmunity. Journal of immunology (Baltimore, Md. : 1950). 2010 Academic Article GET IT
Times cited: 88
Critical appraisal of tocilizumab in the treatment of moderate to severe rheumatoid arthritis. Therapeutics and clinical risk management. 2010 Academic Article GET IT
Significant CD4, CD8, and CD19 lymphopenia in peripheral blood of sarcoidosis patients correlates with severe disease manifestations. PloS one. 2010 Academic Article GET IT
Times cited: 109
Genetic variation at the IRF7/PHRF1 locus is associated with autoantibody profile and serum interferon-alpha activity in lupus patients. Arthritis and rheumatism. 2010 Academic Article GET IT
Times cited: 140
Genetic regulation of serum cytokines in systemic lupus erythematosus. Translational research : the journal of laboratory and clinical medicine. 2009 Review GET IT
Times cited: 60
Clinical characteristics of patients with anti-Jo-1 antibodies: a single center experience. Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases. 2009 Academic Article GET IT
Times cited: 45
Ocrelizumab: a step forward in the evolution of B-cell therapy. Expert opinion on biological therapy. 2009 Review GET IT
Times cited: 55
Elevated serum interferon-alpha activity in juvenile dermatomyositis: associations with disease activity at diagnosis and after thirty-six months of therapy. Arthritis and rheumatism. 2009 Academic Article GET IT
Times cited: 116
Age- and gender-specific modulation of serum osteopontin and interferon-alpha by osteopontin genotype in systemic lupus erythematosus. Genes and immunity. 2009 Academic Article GET IT
Times cited: 95
Cutting edge: autoimmune disease risk variant of STAT4 confers increased sensitivity to IFN-alpha in lupus patients in vivo. Journal of immunology (Baltimore, Md. : 1950). 2009 Academic Article GET IT
Times cited: 206
The PTPN22 C1858T polymorphism is associated with skewing of cytokine profiles toward high interferon-alpha activity and low tumor necrosis factor alpha levels in patients with lupus. Arthritis and rheumatism. 2008 Academic Article GET IT
Times cited: 82
Association of the IRF5 risk haplotype with high serum interferon-alpha activity in systemic lupus erythematosus patients. Arthritis and rheumatism. 2008 Academic Article GET IT
Times cited: 233
Exposure to nuclear antigens contributes to the induction of humoral autoimmunity during tumour necrosis factor alpha blockade. Annals of the rheumatic diseases. 2008 Academic Article GET IT
Times cited: 25
Age- and sex-related patterns of serum interferon-alpha activity in lupus families. Arthritis and rheumatism. 2008 Academic Article GET IT
Times cited: 83
Interferon alpha-induced lupus: proof of principle. Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases. 2008 Editorial Article GET IT
Times cited: 52
Serum type I interferon activity is dependent on maternal diagnosis in anti-SSA/Ro-positive mothers of children with neonatal lupus. Arthritis and rheumatism. 2008 Academic Article GET IT
Times cited: 73
Augmented interferon-alpha pathway activation in patients with Sjögren's syndrome treated with etanercept. Arthritis and rheumatism. 2007 Academic Article GET IT
Times cited: 135
High serum IFN-alpha activity is a heritable risk factor for systemic lupus erythematosus. Genes and immunity. 2007 Academic Article GET IT
Times cited: 371
Anti-CCP antibody testing as a diagnostic and prognostic tool in rheumatoid arthritis. QJM : monthly journal of the Association of Physicians. 2007 Information Resource GET IT
Times cited: 103
Disseminated intravascular coagulation due to cytomegalovirus infection in an immunocompetent adult treated with plasma exchange. 2006 GET IT
Times cited: 8
59-year-old woman with progressive dyspnea on exertion. 2004 GET IT
Times cited: 1
Systemic lupus erythematosus arising during interferon-alpha therapy for cryoglobulinemic vasculitis associated with hepatitis C. Clinical rheumatology. 2004 Review GET IT
Times cited: 148
78-year-old woman with fever, weight loss, and rash. 2003 GET IT
Times cited: 1
27-Year-old woman with numbness and weakness of the extremities. 2003 GET IT
Times cited: 4

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Background

education and training

M.D., University of Illinois College of Medicine 2001
B.S., University of Illinois 1997

Contact

full name

Timothy Niewold

primary email

niewoldt@hss.edu

VIVO Weill Cornell Medical College

Timothy Niewold Professor of Medicine

Publications

selected publications

Background

education and training

Contact

full name

primary email