Type I Interferons in Autoimmunity. Review uri icon

Overview

abstract

  • Dysregulated IFN-1 responses play crucial roles in the development of multiple forms of autoimmunity. Many patients with lupus, systemic sclerosis, Sjogren's syndrome, and dermatomyositis demonstrate enhanced IFN-1 signaling. IFN-1 excess is associated with disease severity and autoantibodies and could potentially predict response to newer therapies targeting IFN-1 pathways. In this review, we provide an overview of the signaling pathway and immune functions of IFN-1s in health and disease. We also review the systemic autoimmune diseases classically associated with IFN-1 upregulation and current therapeutic strategies targeting the IFN-1 system.

publication date

  • January 10, 2022

Research

keywords

  • Interferon Type I
  • Lupus Erythematosus, Systemic
  • Scleroderma, Systemic
  • Sjogren's Syndrome

Identity

PubMed Central ID

  • PMC8860872

Scopus Document Identifier

  • 85122494647

Digital Object Identifier (DOI)

  • 10.1016/j.jid.2021.11.031

PubMed ID

  • 35016780

Additional Document Info

volume

  • 142

issue

  • 3 Pt B