The Journal of investigative dermatology

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Dermatologists' Perspectives and Usage of Large Language Models in Practice: An Exploratory Survey. 2024
Microbes, Autoimmunity, and Cancer: 69th Annual Montagna Symposium on the Biology of Skin. 2024
How Foundation Models Are Shaking the Foundation of Medical Knowledge.. 144. 2023
Plasmacytoid dendritic cells are not major producers of type 1 interferon in cutaneous lupus: An in depth immunoprofile of subacute and discoid lupus. 2023
Expert Agreement on the Presence and Spatial Localization of Melanocytic Features in Dermoscopy.. 144. 2023
Genomic Profiling of the Overlap Phenotype between Psoriasis and Atopic Dermatitis.. 144. 2023
Best Practices for Clinical Skin Image Acquisition in Translational Artificial Intelligence Research.. 143. 2023
Distinct cAMP signaling microdomains differentially regulate melanosomal pH and pigmentation. 2023
Staphylococcus Aureus and Streptococcus Pyogenes Induce Psoriasis-Related Transcriptomes Augmented by IL-17A and TNF-α.. 143. 2023
Improving Artificial Intelligence-Based Diagnosis on Pediatric Skin Lesions.. 143. 2023
Cathelicidin Antimicrobial Peptide LL37 Induces Toll-Like Receptor 8 and Amplifies IL-36γ and IL-17C in Human Keratinocytes.. 143. 2022
Comparison of the Inflammatory Circuits in Psoriasis Vulgaris, Non-Pustular Palmoplantar Psoriasis, and Palmoplantar Pustular Psoriasis. 2022
ANALYZING THE SPATIAL RANDOMNESS IN THE DISTRIBUTION OF ACQUIRED MELANOCYTIC NEOPLASMS. 2022
Steroidogenic Factor-1 Lineage Origin of Skin Lesions in Carney Complex Syndrome.. 142. 2022
Transcriptomic Analysis of the Major Orphan Ichthyosis Subtypes Reveals Shared Immune and Barrier Signatures. 2022
Health-related quality of life differs by race/ethnicity in North American patients with psoriasis: results from PSOLAR. 2022
BMPR1a Is Required for the Optimal TGFβ1-Dependent CD207⁺ Langerhans Cell Differentiation and Limits Skin Inflammation through CD11c⁺ Cells.. 142. 2022
An Epidemiologic Analysis of Melanoma Overdiagnosis in the United States, 1975-2017. 2021
A Randomized Open Label Clinical Trial of Lipid-Lowering Therapy in Psoriasis to Reduce Vascular Endothelial Inflammation. 2021
Classification of Basal Cell Carcinoma in Ex Vivo Confocal Microscopy Images from Freshly Excised Tissues Using a Deep Learning Algorithm. 2021
Chlamydia trachomatis Stimulation Enhances HIV-1 Susceptibility through the Modulation of a Member of the Macrophage Inflammatory Proteins.. 142. 2021
Differences in Psychometric Properties of Clinician and Patient-reported Outcome Measures for Atopic Dermatitis By Race and Skin Tone: A Systematic Review. 2021
Deep Learning for Basal Cell Carcinoma Detection for Reflectance Confocal Microscopy.. 142. 2021
Increased risk of skin cancer in 1851 long-term retinoblastoma survivors. 2021
In-Depth Analysis of the Hidradenitis Suppurativa Serum Proteome Identifies Distinct Inflammatory Subtypes.. 141. 2021
Measurement of Melanin Metabolism in Live Cells by [U-¹³C]-L-Tyrosine Fate Tracing Using Liquid Chromatography-Mass Spectrometry.. 141. 2021
Characterization of PCSK9 in the Blood and Skin of Psoriasis.. 141. 2020
TERT, BRAF, and NRAS Mutational Heterogeneity between Paired Primary and Metastatic Melanoma Tumors.. 140. 2020
Molecular and Cellular Responses to the TYK2/JAK1 Inhibitor PF-06700841 Reveal Reduction of Skin Inflammation in Plaque Psoriasis.. 140. 2020
Decreased CCN3 in Systemic Sclerosis Endothelial Cells Contributes to Impaired Angiogenesis.. 140. 2020
Persistence of Inflammatory Phenotype in Residual Psoriatic Plaques in Patients on Effective Biologic Therapy.. 140. 2019
Early Quantification of Systemic Inflammatory Proteins Predicts Long-Term Treatment Response to Tofacitinib and Etanercept.. 140. 2019
IL-4Rα Blockade by Dupilumab Decreases Staphylococcus aureus Colonization and Increases Microbial Diversity in Atopic Dermatitis.. 140. 2019
Inherited Genetic Variants Associated with Melanoma BRAF/NRAS Subtypes.. 138. 2018
Mutated MITF-E87R in Melanoma Enhances Tumor Progression via S100A4.. 138. 2018
The Major Orphan Forms of Ichthyosis Are Characterized by Systemic T-Cell Activation and Th-17/Tc-17/Th-22/Tc-22 Polarization in Blood.. 138. 2018
Reduction of Inflammatory and Cardiovascular Proteins in the Blood of Patients with Psoriasis: Differential Responses between Tofacitinib and Etanercept after 4 Weeks of Treatment.. 138. 2017
Associations of MC1R Genotype and Patient Phenotypes with BRAF and NRAS Mutations in Melanoma.. 137. 2017
Inhibition of β-Catenin Signaling in the Skin Rescues Cutaneous Adipogenesis in Systemic Sclerosis: A Randomized, Double-Blind, Placebo-Controlled Trial of C-82.. 137. 2017
TNF-α Antagonist and Vascular Inflammation in Patients with Psoriasis Vulgaris: A Randomized Placebo-Controlled Study.. 137. 2017
Phenformin Enhances the Efficacy of ERK Inhibition in NF1-Mutant Melanoma.. 137. 2017
An Integrated Model of Atopic Dermatitis Biomarkers Highlights the Systemic Nature of the Disease.. 137. 2016
Shrinking the Psoriasis Assessment Gap: Early Gene-Expression Profiling Accurately Predicts Response to Long-Term Treatment.. 137. 2016
A Proteome-Derived Longitudinal Pharmacodynamic Biomarker for Diffuse Systemic Sclerosis Skin.. 137. 2016
Discrimination of Dysplastic Nevi from Common Melanocytic Nevi by Cellular and Molecular Criteria.. 136. 2016
The Spectrum of Mild to Severe Psoriasis Vulgaris Is Defined by a Common Activation of IL-17 Pathway Genes, but with Key Differences in Immune Regulatory Genes.. 136. 2016
IL-33-Dependent Group 2 Innate Lymphoid Cells Promote Cutaneous Wound Healing.. 136. 2016
Molecular Phenotyping Small (Asian) versus Large (Western) Plaque Psoriasis Shows Common Activation of IL-17 Pathway Genes but Different Regulatory Gene Sets.. 136. 2016
Lymphatic Function Regulates Contact Hypersensitivity Dermatitis in Obesity.. 135. 2015
Aurora Kinase A Is Upregulated in Cutaneous T-Cell Lymphoma and Represents a Potential Therapeutic Target.. 135. 2015
Fidgetin-Like 2: A Microtubule-Based Regulator of Wound Healing.. 135. 2015
The Characterization of Varicella Zoster Virus-Specific T Cells in Skin and Blood during Aging.. 135. 2015
Assessment of cancer cell line representativeness using microarrays for Merkel cell carcinoma.. 135. 2014
Automated delineation of dermal-epidermal junction in reflectance confocal microscopy image stacks of human skin.. 135. 2014
Molecular characterization of human skin response to diphencyprone at peak and resolution phases: therapeutic insights.. 134. 2014
NOTCH1 mutations occur early during cutaneous squamous cell carcinogenesis.. 134. 2014
Dissection of immune gene networks in primary melanoma tumors critical for antitumor surveillance of patients with stage II-III resectable disease.. 134. 2014
Flt3L dependence helps define an uncharacterized subset of murine cutaneous dendritic cells.. 134. 2013
Gene expression profiling of the leading edge of cutaneous squamous cell carcinoma: IL-24-driven MMP-7.. 134. 2013
Longitudinal study of recurrent metastatic melanoma cell lines underscores the individuality of cancer biology.. 134. 2013
Dominant Th1 and minimal Th17 skewing in discoid lupus revealed by transcriptomic comparison with psoriasis.. 134. 2013
IL-17 and TNF synergistically modulate cytokine expression while suppressing melanogenesis: potential relevance to psoriasis.. 133. 2013
β-Catenin promotes the differentiation of epidermal Langerhans dendritic cells.. 133. 2013
Gene profiling of narrowband UVB-induced skin injury defines cellular and molecular innate immune responses.. 133. 2012
Expanding the psoriasis disease profile: interrogation of the skin and serum of patients with moderate-to-severe psoriasis.. 132. 2012
Stromal fibroblast-specific expression of ADAM-9 modulates proliferation and apoptosis in melanoma cells in vitro and in vivo.. 132. 2012
Histology-specific microRNA alterations in melanoma.. 132. 2012
Protective effect of human endogenous retrovirus K dUTPase variants on psoriasis susceptibility.. 132. 2012
Combined use of laser capture microdissection and cDNA microarray analysis identifies locally expressed disease-related genes in focal regions of psoriasis vulgaris skin lesions.. 132. 2012
Langerhans cells from human cutaneous squamous cell carcinoma induce strong type 1 immunity.. 132. 2012
Investigation of the effect of MDM2 SNP309 and TP53 Arg72Pro polymorphisms on the age of onset of cutaneous melanoma.. 132. 2012
A single intradermal injection of IFN-γ induces an inflammatory state in both non-lesional psoriatic and healthy skin.. 132. 2012
Human keratinocytes' response to injury upregulates CCL20 and other genes linking innate and adaptive immunity.. 132. 2011
Identification of TROP2 (TACSTD2), an EpCAM-like molecule, as a specific marker for TGF-β1-dependent human epidermal Langerhans cells.. 131. 2011
Clinical and dermoscopic stability and volatility of melanocytic nevi in a population-based cohort of children in Framingham school system.. 131. 2011
TNF-α downregulates filaggrin and loricrin through c-Jun N-terminal kinase: role for TNF-α antagonists to improve skin barrier.. 131. 2011
Tumor-associated macrophages in the cutaneous SCC microenvironment are heterogeneously activated.. 131. 2011
Integrative responses to IL-17 and TNF-α in human keratinocytes account for key inflammatory pathogenic circuits in psoriasis.. 131. 2010
Resolved psoriasis lesions retain expression of a subset of disease-related genes.. 131. 2010
The human cutaneous squamous cell carcinoma microenvironment is characterized by increased lymphatic density and enhanced expression of macrophage-derived VEGF-C.. 131. 2010
A subpopulation of CD163-positive macrophages is classically activated in psoriasis.. 130. 2010
Effective narrow-band UVB radiation therapy suppresses the IL-23/IL-17 axis in normalized psoriasis plaques.. 130. 2010
Soluble adenylyl cyclase defines a nuclear cAMP microdomain in keratinocyte hyperproliferative skin diseases.. 130. 2010
Myeloid dendritic cells from human cutaneous squamous cell carcinoma are poor stimulators of T-cell proliferation.. 129. 2009
Evaluation of the clonal origin of multiple primary melanomas using molecular profiling.. 129. 2009
Psoriasis is characterized by accumulation of immunostimulatory and Th1/Th17 cell-polarizing myeloid dendritic cells.. 129. 2008
Effect of therapeutic integrin (CD11a) blockade with efalizumab on immune responses to model antigens in humans: results of a randomized, single blind study.. 128. 2008
Neurotrophins and their receptors stimulate melanoma cell proliferation and migration.. 128. 2008
Blockade of CD11a by efalizumab in psoriasis patients induces a unique state of T-cell hyporesponsiveness.. 128. 2008
Psoriasis vulgaris lesions contain discrete populations of Th1 and Th17 T cells.. 128. 2008
Cellular genomic maps help dissect pathology in human skin disease.. 128. 2007
Insights into gene modulation by therapeutic TNF and IFNgamma antibodies: TNF regulates IFNgamma production by T cells and TNF-regulated genes linked to psoriasis transcriptome.. 128. 2007
Aaron Lerner: perspectives and lessons learned from the melatonin days.. 127. 2007
Increased expression of the orphan nuclear receptor NURR1 in psoriasis and modulation following TNF-alpha inhibition.. 128. 2007
Human basal cell carcinoma is associated with Foxp3+ T cells in a Th2 dominant microenvironment.. 127. 2007
CGRP, PACAP, and VIP modulate Langerhans cell function by inhibiting NF-kappaB activation.. 127. 2007
Filaggrin null alleles are not associated with psoriasis.. 127. 2007
CDKN2A germline mutations in individuals with cutaneous malignant melanoma.. 127. 2007
ATPgammaS enhances the production of inflammatory mediators by a human dermal endothelial cell line via purinergic receptor signaling.. 126. 2006
Prominent production of IL-20 by CD68+/CD11c+ myeloid-derived cells in psoriasis: Gene regulation and cellular effects.. 126. 2006
Delayed cutaneous wound healing in mice lacking solute carrier 11a1 (formerly Nramp1): correlation with decreased expression of secretory leukocyte protease inhibitor.. 126. 2006
Genomic analysis defines a cancer-specific gene expression signature for human squamous cell carcinoma and distinguishes malignant hyperproliferation from benign hyperplasia.. 126. 2006
Dual mode reflectance and fluorescence confocal laser scanning microscopy for in vivo imaging melanoma progression in murine skin.. 125. 2005
Distinction of desmoplastic melanoma from non-desmoplastic melanoma by gene expression profiling.. 124. 2005
Relationship of treatment delay with surgical defect size from keratinocyte carcinoma (basal cell carcinoma and squamous cell carcinoma of the skin).. 124. 2005
Dietary lutein reduces ultraviolet radiation-induced inflammation and immunosuppression.. 122. 2004
Thalidomide inhibits tumor necrosis factor-alpha production and antigen presentation by Langerhans cells.. 121. 2003
Genetic analysis of PSORS1 distinguishes guttate psoriasis and palmoplantar pustulosis.. 120. 2003
Confocal examination of nonmelanoma cancers in thick skin excisions to potentially guide mohs micrographic surgery without frozen histopathology.. 117. 2001
Stress-induced changes in skin barrier function in healthy women.. 117. 2001
Topographic variations in normal skin, as viewed by in vivo reflectance confocal microscopy.. 116. 2001
Anti-CD11a treatment for psoriasis concurrently increases circulating T-cells and decreases plaque T-cells, consistent with inhibition of cutaneous T-cell trafficking. 115. 2000
Intravenous administration of RNA suppresses the induction of delayed-type hypersensitivity (DTH) to tumor-associated antigens. 115. 2000
Tumor antigen presentation by dermal antigen-presenting cells.. 115. 2000
FRAP DNA-dependent protein kinase mediates a late signal transduced from ultraviolet-induced DNA damage.. 114. 2000
Induction of anti-tumor immunity with epidermal cells pulsed with tumor-derived RNA or intradermal administration of RNA.. 114. 2000
Granulocyte-macrophage colony-stimulating factor gene transfer to dendritic cells or epidermal cells augments their antigen-presenting function including induction of anti-tumor immunity.. 113. 1999
The majority of epidermal T cells in Psoriasis vulgaris lesions can produce type 1 cytokines, interferon-gamma, interleukin-2, and tumor necrosis factor-alpha, defining TC1 (cytotoxic T lymphocyte) and TH1 effector populations: a type 1 differentiation bias is also measured in circulating blood T cells in psoriatic patients.. 113. 1999
In vivo confocal scanning laser microscopy of human skin II: advances in instrumentation and comparison with histology.. 113. 1999
Rat preputial sebocyte differentiation involves peroxisome proliferator-activated receptors.. 112. 1999
Differential regulation of epidermal cell tumor-antigen presentation by IL-1alpha and IL-1beta.. 111. 1998
Localization and characterization of the RNA binding protein TLS in skin and stratified mucosa.. 110. 1998
Expression of neurotrophic factors and neuropeptide receptors by Langerhans cells and the Langerhans cell-like cell line XS52: further support for a functional relationship between Langerhans cells and epidermal nerves.. 109. 1997
Identification of aberrantly regulated genes in diseased skin using the cDNA differential display technique.. 108. 1997
Calcitonin gene-related peptide inhibits proliferation and antigen presentation by human peripheral blood mononuclear cells: effects on B7, interleukin 10, and interleukin 12.. 108. 1997
Langerhans cells express inducible nitric oxide synthase and produce nitric oxide.. 107. 1996
Impaired immunosuppressive response to ultraviolet radiation in interleukin-10-deficient mice.. 107. 1996
Inhibition of neutrophil elastase suppresses the development of skin tumors in hairless mice.. 107. 1996
Hyporesponsiveness in contact hypersensitivity and irritant contact dermatitis in CD4 gene targeted mouse.. 106. 1996
The insulin-like growth factor 1 receptor is expressed by epithelial cells with proliferative potential in human epidermis and skin appendages: correlation of increased expression with epidermal hyperplasia.. 106. 1996
Melanocyte differentiation marker gp75, the brown locus protein, can be regulated independently of tyrosinase and pigmentation.. 105. 1995
In vivo confocal scanning laser microscopy of human skin: melanin provides strong contrast.. 104. 1995
Structure-function relations in the inhibition of murine contact hypersensitivity by amiloride.. 104. 1995
Experimental photoaging in C3H/HeN, C3H/HeJ, and Balb/c mice: comparison of changes in extracellular matrix components and mast cell numbers.. 103. 1994
GM-CSF activates regenerative epidermal growth and stimulates keratinocyte proliferation in human skin in vivo.. 103. 1994
Ex vivo and in vivo gene transfer to the skin using replication-deficient recombinant adenovirus vectors.. 102. 1994
Interleukin 1 alpha but not transforming growth factor beta inhibits tumor antigen presentation by epidermal antigen-presenting cells.. 102. 1994
A cohort study of melanoma in patients with dysplastic nevi.. 100. 1993
Growth regulation of cultured human nevus cells.. 100. 1993
Anthralin decreases keratinocyte TGF-alpha expression and EGF-receptor binding in vitro.. 98. 1992
Cyclosporin increases granulocyte/macrophage colony-stimulating factor (GM-CSF) activity and gene expression in murine keratinocytes.. 98. 1992
Studies of the effect of cyclosporine in psoriasis in vivo: combined effects on activated T lymphocytes and epidermal regenerative maturation.. 98. 1992
Junctional epidermolysis bullosa keratinocytes in culture display adhesive, structural, and functional abnormalities.. 97. 1991
Regulation of GM-CSF and IL-3 production from the murine keratinocyte cell line PAM 212 following exposure to ultraviolet radiation.. 97. 1991
Increased dermal expression of platelet-derived growth factor receptors in growth-activated skin wounds and psoriasis.. 96. 1991
Tigliane-type phorbols stimulate human melanocyte proliferation: potentially safer agents for melanocyte culture.. 96. 1991
Synergistic effects of epidermal growth factor (EGF) and insulin-like growth factor I/somatomedin C (IGF-I) on keratinocyte proliferation may be mediated by IGF-I transmodulation of the EGF receptor.. 96. 1991
Longwave ultraviolet radiation (UVA, 320-400 nm)-induced tan protects human skin against further UVA injury.. 93. 1989
Erythrocyte uroporphyrinogen decarboxylase activity in porphyria cutanea tarda: a study of 40 consecutive patients.. 93. 1989
The systemic administration of gamma interferon inhibits collagen synthesis and acute inflammation in a murine skin wounding model.. 93. 1989
Induction of dermal and subcutaneous inflammation by recombinant cachectin/tumor necrosis factor (TNF alpha) in the mouse.. 91. 1988
Evidence for histamine in the urticating hairs of Hylesia moths.. 88. 1987
Prolongation of murine skin allograft survival by the systemic effects of 8-methoxypsoralen and long-wave ultraviolet radiation (PUVA).. 88. 1987
Enhancement of the elicitation phase of the murine contact hypersensitivity response by prior exposure to local ultraviolet radiation.. 86. 1986
Purification and in vitro growth of human epidermal basal keratinocytes using a monoclonal antibody.. 85. 1985
Human complement receptors for C3b (CR1) and C3d (CR2).. 85. 1985
Epidermal I-J-bearing cells are responsible for transferable suppressor cell generation after immunization of mice with ultraviolet radiation-treated epidermal cells.. 84. 1985
Loss of HLA-DR expression by human epidermal cells after growth in culture.. 83. 1984
Association of HLA-DR5 with mycosis fungoides.. 80. 1983
The role of UVB radiation in the induction and elicitation of photocontact hypersensitivity to TCSA in the mouse.. 80. 1983
The collagen alpha-2 chain gene.. 79 Suppl 1. 1982
The molecular aspects of elastin gene expression.. 79 Suppl 1. 1982
Induction of lymphocyte differentiation by epidermal cultures.. 77. 1981
Cell cycle analysis of cultured mammalian cells after exposure to 4,5',8-trimethylpsoralen and long-wave ultraviolet light.. 76. 1981
Proliferative response patterns of human fibroblasts after photoinjury with 4,5',8-trimethylpsoralen.. 76. 1981
Chlorpromazine phototoxicity: growth inhibition and DNA-interaction in normal human fibroblasts.. 75. 1980
Mononuclear phagocyte antimicrobial and antitumor activity: the role of oxygen intermediates.. 74. 1980
Studies in porphyria. VI. Biosynthesis of porphyrins in mammalian skin and in the skin of porphyric patients.. 68. 1977
IL-17C: A Unique Epithelial Cytokine with Potential for Targeting across the Spectrum of Atopic Dermatitis and Psoriasis.. 138. 2018
Docosahexaenoic Acid alleviates atopic dermatitis in mice by generating T regulatory cells and m2 macrophages.. 135. 2015
Silver sulfadiazine retards wound healing in mice via alterations in cytokine expression.. 135. 2015
IL-17 induces inflammation-associated gene products in blood monocytes, and treatment with ixekizumab reduces their expression in psoriasis patient blood.. 134. 2014
Crossing the barrier: STRA6 in epidermal differentiation.. 134. 2014
Factors associated with nevus volatility in early adolescence.. 134. 2014
Dermal clusters of mature dendritic cells and T cells are associated with the CCL20/CCR6 chemokine system in chronic psoriasis.. 134. 2013
Creation of differentiation-specific genomic maps of human epidermis through laser capture microdissection.. 133. 2013
Epidermal ADAM17 is dispensable for notch activation.. 133. 2013
Rare pathogenic variants in IL36RN underlie a spectrum of psoriasis-associated pustular phenotypes.. 133. 2013
Risk of skin cancer associated with the use of UV nail lamp.. 133. 2012
Anti-IL-17 receptor antibody AMG 827 leads to rapid clinical response in subjects with moderate to severe psoriasis: results from a phase I, randomized, placebo-controlled trial.. 132. 2012
Transcriptional profiling of psoriasis using RNA-seq reveals previously unidentified differentially expressed genes.. 132. 2011
Deletion of PTENP1 pseudogene in human melanoma.. 131. 2011
Interaction of CDKN2A and sun exposure in the etiology of melanoma in the general population.. 131. 2011
Melanoma molecular subtypes: unifying and paradoxical results.. 130. 2010
Relationship between germline MC1R variants and BRAF-mutant melanoma in a North Carolina population-based study.. 130. 2009
Double-blind, placebo-controlled, dose-escalation study to evaluate the pharmacologic effect of CP-690,550 in patients with psoriasis.. 129. 2009
Increased JunB mRNA and protein expression in psoriasis vulgaris lesions.. 126. 2006
Bringing histology to the bedside.. 124. 2005
Non-invasive (real-time) imaging of histologic margin of a proliferative skin lesion in vivo.. 111. 1998
Inherited Melanoma Risk Variants Associated with Histopathologically Amelanotic Melanoma. 2019
Relationship of Chromosome Arm 10q Variants to Occurrence of Multiple Primary Melanoma in the Population-Based Genes, Environment, and Melanoma (GEM) Study. 2018
Activation of the Mitochondrial Fragmentation Protein DRP1 Correlates with BRAF(V600E) Melanoma. 2015
Stress and the skin: a meeting report of the Weill Cornell Symposium on the Science of Dermatology. 2006
The ever-evolving landscape for detection of early melanoma: challenges and promises.. 133. 2013
The emerging role of IL-17 in the pathogenesis of psoriasis: preclinical and clinical findings. 2012
Psoriasis and systemic inflammatory diseases: potential mechanistic links between skin disease and co-morbid conditions. 2010
Resident and "inflammatory" dendritic cells in human skin. 2008
Type I Interferons in Autoimmunity. 2022
Immune Checkpoint Blockade and Skin Toxicity Pathogenesis. 2021

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