Expression of MHC class I genes in mouse hepatitis virus (MHV-A59) infection and in multiple sclerosis. Academic Article uri icon

Overview

abstract

  • Our studies revealed that virus induced demyelination as well as human inflammatory demyelination involves upregulation of class I MHC genes and surface expression of antigens encoded by these genes. Induction involves the action of an intermediate soluble factor/s which is at present unknown. These findings suggest that MHC class I restricted, cytotoxic T lymphocyte (CTL) reactions, against self or foreign antigens may play a role in these conditions. These findings may help to elucidate the mechanism of coronavirus-induced demyelination as well as the pathogenesis of multiple sclerosis.

publication date

  • January 1, 1987

Research

keywords

  • Hepatitis, Viral, Animal
  • Major Histocompatibility Complex
  • Multiple Sclerosis

Identity

Scopus Document Identifier

  • 0023511689

PubMed ID

  • 2829530

Additional Document Info

volume

  • 218