Emerging Variants of Castration-Resistant Prostate Cancer. Review uri icon

Overview

abstract

  • Metastatic castration-resistant prostate cancer (CRPC) is associated with substantial clinical, pathologic, and molecular heterogeneity. Most tumors remain driven by androgen receptor (AR) signaling, which has clinical implications for patient selection for AR-directed approaches. However, histologic and clinical resistance phenotypes can emerge after AR inhibition, in which the tumors become less dependent on the AR. In this review, we discuss prostate cancer variants including neuroendocrine (NEPC) and aggressive variant (AVPC) prostate cancers and their clinical implications. Improvements in the understanding of the biologic mechanisms and molecular features underlying prostate cancer variants may help prognostication and facilitate the development of novel therapeutic approaches for subclasses of patient with CRPC.

publication date

  • May 1, 2017

Research

keywords

  • Neuroendocrine Tumors
  • Prostatic Neoplasms, Castration-Resistant
  • Receptors, Androgen

Identity

PubMed Central ID

  • PMC5479409

Scopus Document Identifier

  • 85016776770

Digital Object Identifier (DOI)

  • 10.1007/s11912-017-0593-6

PubMed ID

  • 28361223

Additional Document Info

volume

  • 19

issue

  • 5