Beltran, Himisha

Publications

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selected publications

Small extracellular vesicles modulated by αVβ3 integrin induce neuroendocrine differentiation in recipient cancer cells. Journal of extracellular vesicles. 2020 Academic Article GET IT
Times cited: 23
ABEMUS: platform-specific and data-informed detection of somatic SNVs in cfDNA. Bioinformatics (Oxford, England). 2020 Academic Article GET IT
Circulating tumor DNA profile recognizes transformation to castration-resistant neuroendocrine prostate cancer. The Journal of clinical investigation. 2020 Academic Article GET IT
Times cited: 110
PIM protein kinases regulate the level of the long noncoding RNA H19 to control stem cell gene transcription and modulate tumor growth. Molecular oncology. 2020 Academic Article GET IT
Times cited: 18
SLFN11 Expression in Advanced Prostate Cancer and Response to Platinum-based Chemotherapy. Molecular cancer therapeutics. 2020 Academic Article GET IT
Docetaxel for Early Prostate Cancer: What Have We Learned?. European urology. 2020 Editorial Article GET IT
Management of Patients with Advanced Prostate Cancer: Report of the Advanced Prostate Cancer Consensus Conference 2019. European urology. 2020 Conference Paper GET IT
Androgen deprivation upregulates SPINK1 expression and potentiates cellular plasticity in prostate cancer. Nature communications. 2020 Academic Article GET IT
Times cited: 48
Genomic and clinical characterization of stromal infiltration markers in prostate cancer. Cancer. 2020 Academic Article GET IT
Times cited: 10
Molecular Biomarkers in Localized Prostate Cancer: ASCO Guideline. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2019 Academic Article GET IT
Times cited: 44
Organotypic tumor slice cultures provide a versatile platform for immuno-oncology and drug discovery. Oncoimmunology. 2019 Academic Article GET IT
Times cited: 50
Towards precision oncology in advanced prostate cancer. Nature reviews. Urology. 2019 Information Resource GET IT
Times cited: 154
The Balancing Act: Assessing Treatment Burden Versus Treatment Benefit with Evolving Metastatic Hormone-sensitive Prostate Cancer Data. European urology. 2019 Editorial Article GET IT
Integrative Molecular Analysis of Patients With Advanced and Metastatic Cancer. JCO precision oncology. 2019 Academic Article GET IT
Times cited: 31
Clinical features of neuroendocrine prostate cancer. European journal of cancer. 2019 Academic Article GET IT
Times cited: 179
PARP Inhibition Suppresses GR-MYCN-CDK5-RB1-E2F1 Signaling and Neuroendocrine Differentiation in Castration-Resistant Prostate Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. 2019 Academic Article GET IT
Times cited: 45
Proteomic and genomic signatures of repeat instability in cancer and adjacent normal tissues. Proceedings of the National Academy of Sciences of the United States of America. 2019 Academic Article GET IT
Times cited: 11
Cancer-Specific Thresholds Adjust for Whole Exome Sequencing-based Tumor Mutational Burden Distribution. JCO precision oncology. 2019 Academic Article GET IT
Times cited: 23
Upper tract urothelial carcinoma has a luminal-papillary T-cell depleted contexture and activated FGFR3 signaling. Nature communications. 2019 Academic Article GET IT
Times cited: 128
N-Myc-mediated epigenetic reprogramming drives lineage plasticity in advanced prostate cancer. The Journal of clinical investigation. 2019 Academic Article GET IT
Times cited: 103
Transcriptomic and Clinical Characterization of Neuropeptide Y Expression in Localized and Metastatic Prostate Cancer: Identification of Novel Prostate Cancer Subtype with Clinical Implications. European urology oncology. 2019 Academic Article GET IT
Times cited: 14
Genomic correlates of clinical outcome in advanced prostate cancer. Proceedings of the National Academy of Sciences of the United States of America. 2019 Academic Article GET IT
Times cited: 711
Ultrasensitive detection of cancer biomarkers by nickel-based isolation of polydisperse extracellular vesicles from blood. EBioMedicine. 2019 Academic Article GET IT
Times cited: 33
Phase 1/2 study of fractionated dose lutetium-177-labeled anti-prostate-specific membrane antigen monoclonal antibody J591 (¹⁷⁷ Lu-J591) for metastatic castration-resistant prostate cancer. Cancer. 2019 Academic Article GET IT
Times cited: 33
CHD1 Loss Alters AR Binding at Lineage-Specific Enhancers and Modulates Distinct Transcriptional Programs to Drive Prostate Tumorigenesis. Cancer cell. 2019 Academic Article GET IT
Times cited: 55
Delta-like protein 3 expression and therapeutic targeting in neuroendocrine prostate cancer. Science translational medicine. 2019 Academic Article GET IT
Times cited: 101
Increased Serine and One-Carbon Pathway Metabolism by PKCλ/ι Deficiency Promotes Neuroendocrine Prostate Cancer. Cancer cell. 2019 Academic Article GET IT
Times cited: 129
Biological Evolution of Castration-resistant Prostate Cancer. European urology focus. 2019 Information Resource GET IT
Times cited: 20
The application of precision medicine in diagnosing familial Mediterranean fever. Leukemia & lymphoma. 2019 Letter GET IT
ONECUT2 is a driver of neuroendocrine prostate cancer. Nature communications. 2019 Academic Article GET IT
Times cited: 143
Low Tristetraprolin Expression Is Associated with Lethal Prostate Cancer. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2018 Academic Article GET IT
Times cited: 7
Plasma androgen receptor and serum chromogranin A in advanced prostate cancer. Scientific reports. 2018 Academic Article GET IT
Times cited: 19
A Phase II Trial of the Aurora Kinase A Inhibitor Alisertib for Patients with Castration-resistant and Neuroendocrine Prostate Cancer: Efficacy and Biomarkers. Clinical cancer research : an official journal of the American Association for Cancer Research. 2018 Academic Article GET IT
Times cited: 158
Linking prostate cancer cell AR heterogeneity to distinct castration and enzalutamide responses. Nature communications. 2018 Academic Article GET IT
Times cited: 90
Biallelic tumour suppressor loss and DNA repair defects in de novo small-cell prostate carcinoma. The Journal of pathology. 2018 Academic Article GET IT
Times cited: 18
Evolving Intersection Between Inherited Cancer Genetics and Therapeutic Clinical Trials in Prostate Cancer: A White Paper From the Germline Genetics Working Group of the Prostate Cancer Clinical Trials Consortium. JCO precision oncology. 2018 Academic Article GET IT
Times cited: 20
Clinical and Genomic Characterization of Treatment-Emergent Small-Cell Neuroendocrine Prostate Cancer: A Multi-institutional Prospective Study. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2018 Academic Article GET IT
Times cited: 436
Suppression of insulin feedback enhances the efficacy of PI3K inhibitors. Nature. 2018 Academic Article GET IT
Times cited: 418
BRCA2-Associated Prostate Cancer in a Patient With Spinal and Bulbar Muscular Atrophy. JCO precision oncology. 2018 Academic Article GET IT
Patient derived organoids to model rare prostate cancer phenotypes. Nature communications. 2018 Academic Article GET IT
Times cited: 231
The long noncoding RNA landscape of neuroendocrine prostate cancer and its clinical implications. GigaScience. 2018 Academic Article GET IT
Times cited: 51
CATCH-KB: Establishing a Pharmacogenomics Variant Repository for Chemotherapy-Induced Cardiotoxicity. AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science. 2018 Academic Article GET IT
Impact of Therapy on Genomics and Transcriptomics in High-Risk Prostate Cancer Treated with Neoadjuvant Docetaxel and Androgen Deprivation Therapy. Clinical cancer research : an official journal of the American Association for Cancer Research. 2018 Academic Article GET IT
Times cited: 64
The long tail of oncogenic drivers in prostate cancer. Nature genetics. 2018 Academic Article GET IT
Times cited: 523
Cellular plasticity and the neuroendocrine phenotype in prostate cancer. Nature reviews. Urology. 2018 Information Resource GET IT
Times cited: 127
Clinical Outcome of Prostate Cancer Patients with Germline DNA Repair Mutations: Retrospective Analysis from an International Study. European urology. 2018 Academic Article GET IT
Times cited: 98
Bone biopsy protocol for advanced prostate cancer in the era of precision medicine. Cancer. 2017 Academic Article GET IT
Times cited: 38
Aberrant Activation of a Gastrointestinal Transcriptional Circuit in Prostate Cancer Mediates Castration Resistance. Cancer cell. 2017 Academic Article GET IT
Times cited: 49
Management of Patients with Advanced Prostate Cancer: The Report of the Advanced Prostate Cancer Consensus Conference APCCC 2017. European urology. 2017 Conference Paper GET IT
Times cited: 307
Next-Generation Rapid Autopsies Enable Tumor Evolution Tracking and Generation of Preclinical Models. JCO precision oncology. 2017 Academic Article GET IT
Times cited: 40
A germline FANCA alteration that is associated with increased sensitivity to DNA damaging agents. Cold Spring Harbor molecular case studies. 2017 Academic Article GET IT
Times cited: 22
Emerging Variants of Castration-Resistant Prostate Cancer. Current oncology reports. 2017 Information Resource GET IT
Times cited: 133
Transplantation of engineered organoids enables rapid generation of metastatic mouse models of colorectal cancer. Nature biotechnology. 2017 Academic Article GET IT
Times cited: 171
On-site Cytology for Development of Patient-Derived Three-dimensional Organoid Cultures - A Pilot Study. Anticancer research. 2017 Academic Article GET IT
Times cited: 5
Personalized In Vitro and In Vivo Cancer Models to Guide Precision Medicine. Cancer discovery. 2017 Academic Article GET IT
Times cited: 677
SOX2 promotes lineage plasticity and antiandrogen resistance in TP53- and RB1-deficient prostate cancer. Science (New York, N.Y.). 2017 Academic Article GET IT
Times cited: 672
Prostate cancer in 2016: Improved outcomes and precision medicine come within reach. Nature reviews. Urology. 2017 Information Resource GET IT
Times cited: 2
Personalizing Therapy for Metastatic Prostate Cancer: The Role of Solid and Liquid Tumor Biopsies. American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting. 2017 Information Resource GET IT
Times cited: 4
Synthetic lethality and beyond. Science translational medicine. 2016 Article GET IT
The Master Neural Transcription Factor BRN2 Is an Androgen Receptor-Suppressed Driver of Neuroendocrine Differentiation in Prostate Cancer. Cancer discovery. 2016 Academic Article GET IT
Times cited: 143
Clonal evolution of chemotherapy-resistant urothelial carcinoma. Nature genetics. 2016 Academic Article GET IT
Times cited: 220
N-Myc Induces an EZH2-Mediated Transcriptional Program Driving Neuroendocrine Prostate Cancer. Cancer cell. 2016 Academic Article GET IT
Times cited: 368
Development and validation of a whole-exome sequencing test for simultaneous detection of point mutations, indels and copy-number alterations for precision cancer care. NPJ genomic medicine. 2016 Academic Article GET IT
Times cited: 63
Inherited DNA-Repair Gene Mutations in Men with Metastatic Prostate Cancer. The New England journal of medicine. 2016 Academic Article GET IT
Times cited: 1123
SRRM4 Drives Neuroendocrine Transdifferentiation of Prostate Adenocarcinoma Under Androgen Receptor Pathway Inhibition. European urology. 2016 Academic Article GET IT
Times cited: 94
Management of patients with advanced prostate cancer: recommendations of the St Gallen Advanced Prostate Cancer Consensus Conference (APCCC) 2015. Annals of oncology : official journal of the European Society for Medical Oncology. 2016 Academic Article GET IT
PO-43 - Differential coagulation factor expression in neuroendocrine prostate cancer (PC), metastatic castrate-resistant PC, and localized prostatic adenocarcinoma. Thrombosis research. 2016 Academic Article GET IT
Divergent clonal evolution of castration-resistant neuroendocrine prostate cancer. Nature medicine. 2016 Academic Article GET IT
Times cited: 1059
Emerging Molecular Biomarkers in Advanced Prostate Cancer: Translation to the Clinic. American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting. 2016 Academic Article GET IT
Times cited: 18
The Initial Detection and Partial Characterization of Circulating Tumor Cells in Neuroendocrine Prostate Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. 2015 Academic Article GET IT
Times cited: 109
The Placental Gene PEG10 Promotes Progression of Neuroendocrine Prostate Cancer. Cell reports. 2015 Academic Article GET IT
Times cited: 135
Whole-Exome Sequencing of Metastatic Cancer and Biomarkers of Treatment Response. JAMA oncology. 2015 Academic Article GET IT
Times cited: 226
Integrative clinical genomics of advanced prostate cancer. Cell. 2015 Academic Article GET IT
Times cited: 2347
CRIPTO overexpression promotes mesenchymal differentiation in prostate carcinoma cells through parallel regulation of AKT and FGFR activities. Oncotarget. 2015 Academic Article GET IT
Times cited: 21
Prioritizing precision medicine for prostate cancer. Annals of oncology : official journal of the European Society for Medical Oncology. 2015 Editorial Article GET IT
Times cited: 7
The spectrum of neuroendocrine tumors: histologic classification, unique features and areas of overlap. American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting. 2015 Information Resource GET IT
Times cited: 36
ERG induces taxane resistance in castration-resistant prostate cancer. Nature communications. 2014 Academic Article GET IT
Times cited: 95
The oestrogen receptor alpha-regulated lncRNA NEAT1 is a critical modulator of prostate cancer. Nature communications. 2014 Academic Article GET IT
Times cited: 519
Organoid cultures derived from patients with advanced prostate cancer. Cell. 2014 Academic Article GET IT
Times cited: 1084
Unraveling the clonal hierarchy of somatic genomic aberrations. Genome biology. 2014 Academic Article GET IT
Times cited: 78
Prostate cancer with Paneth cell-like neuroendocrine differentiation has recognizable histomorphology and harbors AURKA gene amplification. Human pathology. 2014 Academic Article GET IT
Times cited: 28
Proposed morphologic classification of prostate cancer with neuroendocrine differentiation. The American journal of surgical pathology. 2014 Academic Article GET IT
Times cited: 397
Aggressive variants of castration-resistant prostate cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. 2014 Information Resource GET IT
Times cited: 317
The many faces of neuroendocrine differentiation in prostate cancer progression. Frontiers in oncology. 2014 Information Resource GET IT
Times cited: 182
The N-myc Oncogene: Maximizing its Targets, Regulation, and Therapeutic Potential. Molecular cancer research : MCR. 2014 Information Resource GET IT
Times cited: 76
High fidelity patient-derived xenografts for accelerating prostate cancer discovery and drug development. Cancer research. 2013 Academic Article GET IT
Times cited: 217
Development and validation of a clinical cancer genomic profiling test based on massively parallel DNA sequencing. Nature biotechnology. 2013 Academic Article GET IT
Times cited: 1616
Cross modulation between the androgen receptor axis and protocadherin-PC in mediating neuroendocrine transdifferentiation and therapeutic resistance of prostate cancer. Neoplasia (New York, N.Y.). 2013 Academic Article GET IT
Punctuated evolution of prostate cancer genomes. Cell. 2013 Academic Article GET IT
Times cited: 966
Epigenomic alterations in localized and advanced prostate cancer. Neoplasia (New York, N.Y.). 2013 Academic Article GET IT
DNA mismatch repair in prostate cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2013 Academic Article GET IT
Times cited: 8
Concurrent AURKA and MYCN gene amplifications are harbingers of lethal treatment-related neuroendocrine prostate cancer. Neoplasia (New York, N.Y.). 2013 Academic Article GET IT
Times cited: 199
Epigenetic repression of miR-31 disrupts androgen receptor homeostasis and contributes to prostate cancer progression. Cancer research. 2012 Academic Article GET IT
Times cited: 152
Targeted next-generation sequencing of advanced prostate cancer identifies potential therapeutic targets and disease heterogeneity. European urology. 2012 Academic Article GET IT
Times cited: 344
From sequence to molecular pathology, and a mechanism driving the neuroendocrine phenotype in prostate cancer. The Journal of pathology. 2012 Academic Article GET IT
Times cited: 154
Identification of functionally active, low frequency copy number variants at 15q21.3 and 12q21.31 associated with prostate cancer risk. Proceedings of the National Academy of Sciences of the United States of America. 2012 Academic Article GET IT
Times cited: 42
Molecular characterization of neuroendocrine prostate cancer and identification of new drug targets. Cancer discovery. 2011 Academic Article GET IT
Times cited: 690
Novel therapeutics for the management of castration-resistant prostate cancer (CRPC). BJU international. 2011 Information Resource GET IT
Times cited: 20
Abiraterone plus prednisone improves survival in metastatic castration-resistant prostate cancer. Asian journal of andrology. 2011 Article GET IT
Times cited: 2
New therapies for castration-resistant prostate cancer: efficacy and safety. European urology. 2011 Information Resource GET IT
Times cited: 114

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Research

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missing activity Co-Investigator 2017 - 2022

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Background

education and training

M.D., New York Medical College 2004
B.S., University of Oregon 2000

Contact

full name

Himisha Beltran

primary email

hip9004@med.cornell.edu

VIVO Weill Cornell Medical College

Himisha Beltran Adjunct Associate Professor of Medicine

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email