The Role of Next-Generation Sequencing in Precision Medicine: A Review of Outcomes in Oncology. Academic Article uri icon



  • Precision medicine seeks to use genomic data to help provide the right treatment to the right patient at the right time. Next-generation sequencing technology allows for the rapid and accurate sequencing of many genes at once. This technology is becoming more common in oncology, though the clinical benefit of incorporating it into precision medicine strategies remains under significant debate. In this manuscript, we discuss the early findings of the impact of next-generation sequencing on cancer patient outcomes. We investigate why not all patients with genomic variants linked to a specific therapy receive that therapy and describe current barriers. Finally, we explore the current state of health insurance coverage for individual genome sequencing and targeted therapies for cancer. Based on our analysis, we recommend increased transparency around the determination of "actionable mutations" and a heightened focus on investigating the variations in health insurance coverage across patients receiving sequencing-matched therapies.

publication date

  • September 17, 2018


PubMed Central ID

  • PMC6164147

Scopus Document Identifier

  • 85054709229

Digital Object Identifier (DOI)

  • 10.3390/jpm8030030

PubMed ID

  • 30227640

Additional Document Info


  • 8


  • 3